Mathematical Modeling And Validation In Physiology
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Mathematical Modeling And Validation In Physiology
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Author : Jerry J. Batzel
language : en
Publisher: Springer
Release Date : 2012-12-14
Mathematical Modeling And Validation In Physiology written by Jerry J. Batzel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-14 with Mathematics categories.
This volume synthesizes theoretical and practical aspects of both the mathematical and life science viewpoints needed for modeling of the cardiovascular-respiratory system specifically and physiological systems generally. Theoretical points include model design, model complexity and validation in the light of available data, as well as control theory approaches to feedback delay and Kalman filter applications to parameter identification. State of the art approaches using parameter sensitivity are discussed for enhancing model identifiability through joint analysis of model structure and data. Practical examples illustrate model development at various levels of complexity based on given physiological information. The sensitivity-based approaches for examining model identifiability are illustrated by means of specific modeling examples. The themes presented address the current problem of patient-specific model adaptation in the clinical setting, where data is typically limited.
Applied Mathematical Models In Human Physiology
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Author : Johnny T. Ottesen
language : en
Publisher: SIAM
Release Date : 2004-01-01
Applied Mathematical Models In Human Physiology written by Johnny T. Ottesen and has been published by SIAM this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-01 with Medical categories.
This book introduces mathematicians to real applications from physiology. Using mathematics to analyze physiological systems, the authors focus on models reflecting current research in cardiovascular and pulmonary physiology. In particular, they present models describing blood flow in the heart and the cardiovascular system, as well as the transport of oxygen and carbon dioxide through the respiratory system and a model for baroreceptor regulation.
Introduction To Modeling In Physiology And Medicine
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Author : Claudio Cobelli
language : en
Publisher: Elsevier
Release Date : 2008-02-06
Introduction To Modeling In Physiology And Medicine written by Claudio Cobelli and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-06 with Technology & Engineering categories.
This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises
Modeling And Simulation In Biomedical Engineering Applications In Cardiorespiratory Physiology
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Author : Willem L. van Meurs
language : en
Publisher: McGraw Hill Professional
Release Date : 2011-08-07
Modeling And Simulation In Biomedical Engineering Applications In Cardiorespiratory Physiology written by Willem L. van Meurs and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-07 with Technology & Engineering categories.
THEORY AND PRACTICE OF MODELING AND SIMULATING HUMAN PHYSIOLOGY Written by a coinventor of the Human Patient Simulator (HPS) and past president of the Society in Europe for Simulation Applied to Medicine (SESAM), Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology is a compact and consistent introduction to this expanding field. The book divides the modeling and simulation process into five manageable steps--requirements, conceptual models, mathematical models, software implementation, and simulation results and validation. A framework and a basic set of deterministic, continuous-time models for the cardiorespiratory system are provided. This timely resource also addresses advanced topics, including sensitivity analysis and setting model requirements as part of an encompassing simulation and simulator design. Practical examples provide you with the skills to evaluate and adapt existing physiologic models or create new ones for specific applications. Coverage includes: Signals and systems Model requirements Conceptual models Mathematical models Software implementation Simulation results and model validation Cardiorespiratory system model Circulation Respiration Physiologic control Sensitivity analysis of a cardiovascular model Design of model-driven acute care training simulators “Uniquely qualified to author such a text, van Meurs is one of the original developers of CAE Healthcare’s Human Patient Simulator (HPS). ...His understanding of mathematics, human physiology, pharmacology, control systems, and systems engineering, combined with a conversational writing style, results in a readable text. ...The ample illustrations and tables also break up the text and make reading the book easier on the eyes. ...concise yet in conversational style, with real-life examples. This book is highly recommended for coursework in physiologic modeling and for all who are interested in simulator design and development. The book pulls all these topics together under one cover and is an important contribution to biomedical literature.” --IEEE Pulse, January 2014 “This book is written by a professional engineer who is unique in that he seems to have a natural understanding of 3 key areas as follows: the hardware involved with simulators, human physiology, and mathematical modeling. Willem van Meurs is one of the inventors of the model-driven human patient simulator (HPS), and so, he is very qualified to write this book. The book is written in a clear way, using the first person throughout, in a conversational manner, with a style that involves posing questions and answering them in subsequent text. ...The book starts with a very useful introduction and background chapter, setting out the scene for the rest of the book. ...I have used his book in enhancing my own talks and understanding human patient simulation and can strongly recommend it.” --Simulation in Healthcare December, 2012 Reviewed by Mark A. Tooley, Ph.D., Department of Medical Physics and Bioengineering, Royal United Hospital, Combe Park, Bath, UK.
A Course In Mathematical Biology
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Author : Gerda de Vries
language : en
Publisher: SIAM
Release Date : 2006-07-01
A Course In Mathematical Biology written by Gerda de Vries and has been published by SIAM this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-01 with Mathematics categories.
This is the only book that teaches all aspects of modern mathematical modeling and that is specifically designed to introduce undergraduate students to problem solving in the context of biology. Included is an integrated package of theoretical modeling and analysis tools, computational modeling techniques, and parameter estimation and model validation methods, with a focus on integrating analytical and computational tools in the modeling of biological processes. Divided into three parts, it covers basic analytical modeling techniques; introduces computational tools used in the modeling of biological problems; and includes various problems from epidemiology, ecology, and physiology. All chapters include realistic biological examples, including many exercises related to biological questions. In addition, 25 open-ended research projects are provided, suitable for students. An accompanying Web site contains solutions and a tutorial for the implementation of the computational modeling techniques. Calculations can be done in modern computing languages such as Maple, Mathematica, and MATLAB?.
Applied Mathematical Models In Human Physiology
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Author : Johnny T. Ottesen
language : en
Publisher: SIAM
Release Date : 2004-02-01
Applied Mathematical Models In Human Physiology written by Johnny T. Ottesen and has been published by SIAM this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-02-01 with Medical categories.
This book introduces mathematicians to real applications from physiology. Using mathematics to analyze physiological systems, the authors discuss models reflecting current research in cardiovascular and pulmonary physiology. In particular, they present models describing blood flow in the heart and the cardiovascular system, as well as the transport of oxygen and carbon dioxide through the respiratory system and a model for baroreceptor regulation. This is the only book available that analyzes up-to-date models of the physiological system at several levels of detail; both simple 'real-time' models that can be directly used in larger systems, and more detailed 'reference' models that show the underlying physiological mechanisms and provide parameters for and validation of simpler models. The book also covers two-dimensional modeling of the fluid dynamics in the heart and its ability to pump, and includes a discussion of modeling wave-propagation throughout the systemic arteries.
Mathematically Modelling The Electrical Activity Of The Heart From Cell To Body Surface And Back Again
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Author : Andrew Pullan
language : en
Publisher: World Scientific Publishing Company
Release Date : 2005-09-07
Mathematically Modelling The Electrical Activity Of The Heart From Cell To Body Surface And Back Again written by Andrew Pullan and has been published by World Scientific Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-07 with Science categories.
This book on modelling the electrical activity of the heart is an attempt to describe continuum based modelling of cardiac electrical activity from the cell level to the body surface (the forward problem), and back again (the inverse problem). Background anatomy and physiology is covered briefly to provide a suitable context for understanding the detailed modelling that is presented herein. The questions of what is mathematical modelling and why one would want to use mathematical modelling are addressed to give some perspective to the philosophy behind our approach. Our view of mathematical modelling is broad — it is not simply about obtaining a solution to a set of mathematical equations, but includes some material on aspects such as experimental and clinical validation.
Computational Modeling In Biomedical Engineering And Medical Physics
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Author : Alexandru Morega
language : en
Publisher: Academic Press
Release Date : 2020-09-18
Computational Modeling In Biomedical Engineering And Medical Physics written by Alexandru Morega and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-18 with Science categories.
Mathematical and numerical modelling of engineering problems in medicine is aimed at unveiling and understanding multidisciplinary interactions and processes and providing insights useful to clinical care and technology advances for better medical equipment and systems. When modelling medical problems, the engineer is confronted with multidisciplinary problems of electromagnetism, heat and mass transfer, and structural mechanics with, possibly, different time and space scales, which may raise concerns in formulating consistent, solvable mathematical models. Computational Medical Engineering presents a number of engineering for medicine problems that may be encountered in medical physics, procedures, diagnosis and monitoring techniques, including electrical activity of the heart, hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave hyperthermia, ablation, EMF dosimetry, and bioimpedance methods. The authors discuss the core approach methodology to pose and solve different problems of medical engineering, including essentials of mathematical modelling (e.g., criteria for well-posed problems); physics scaling (homogenization techniques); Constructal Law criteria in morphing shape and structure of systems with internal flows; computational domain construction (CAD and, or reconstruction techniques based on medical images); numerical modelling issues, and validation techniques used to ascertain numerical simulation results. In addition, new ideas and venues to investigate and understand finer scale models and merge them into continuous media medical physics are provided as case studies.
Principles Of Mathematical Modeling
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Author : Clive Dym
language : en
Publisher: Academic Press
Release Date : 2004-06-21
Principles Of Mathematical Modeling written by Clive Dym and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-21 with Mathematics categories.
This book provides a readable and informative introduction to the development and application of mathematical models in science and engineering. The first half of the book begins with a clearly defined set of modeling principles, and then introduces a set of foundational tools (dimensional analysis, scaling techniques, and approximation and validation techniques). The second half then applies these foundational tools to a broad variety of subjects, including exponenttial growth and decay in fields ranging from biology to economics, traffic flow, free and forced vibration of mechanical and other systems, and optimization problems in biology, structures, and social decision making. An extensive collection of more than 360 problems offer ample opportunity in both a formal course and for the individual reader. (Midwest).
Introduction To Modeling In Physiology And Medicine
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Author : Claudio Cobelli
language : en
Publisher: Academic Press
Release Date : 2019-08-01
Introduction To Modeling In Physiology And Medicine written by Claudio Cobelli and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-01 with Computers categories.
Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear understanding of the fundamental principles of good modeling methodology. Sections show how to create valid mathematical models that are fit for a range of purposes. These models are supported by detailed explanation, extensive case studies, examples and applications. This updated edition includes clearer guidance on the mathematical prerequisites needed to achieve the maximum benefit from the material, a greater detail regarding basic approaches to modeling, and discussions on non-linear and stochastic modeling. The range of case study material has been substantially extended, with examples drawn from recent research experience. Key examples include a cellular model of insulin secretion and its extension to the whole-body level, a model of insulin action during a meal/oral glucose tolerance test, a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials. - Covers the underlying principles of good quantitative modeling methodology, with applied biomedical engineering and bioscience examples to ensure relevance to students, current research and clinical practice - Includes modeling data, modeling systems, linear and non-linear systems, model identification, parametric and non-parametric models, and model validation - Presents clear, step-by-step working plus examples and extensive case studies that relate concepts to real world applications - Provides end-of-chapter exercises and assignments to reinforce learning