Mathematical Modeling Of Oxygen Transport Cell Killing And Cell Decision Making In Photodynamic Therapy Of Cancer
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Mathematical Modeling Of Oxygen Transport Cell Killing And Cell Decision Making In Photodynamic Therapy Of Cancer
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Author : Ioannis Gkigkitzis
language : en
Publisher:
Release Date : 2012
Mathematical Modeling Of Oxygen Transport Cell Killing And Cell Decision Making In Photodynamic Therapy Of Cancer written by Ioannis Gkigkitzis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Cancer categories.
In this study we present a model of in vitro cell killing through type II Photodynamic Therapy (PDT) for simulation of the molecular interactions leading to cell death in time domain in the presence of oxygen transport within a spherical cell. By coupling the molecular kinetics to cell killing, we develop a modeling method of PDT cytotoxicity caused by singlet oxygen and obtain the cell survival ratio as a function of light fluence or initial photosensitizer concentration with different photon density or irradiance of incident light and other parameters of oxygen transport. A systems biology model is developed to account for the detailed molecular pathways induced by PDT treatment leading to cell killing. We derive a mathematical model of cell decision making through a binary cell fate decision scheme on cell death or survival, during and after PDT treatment, and we employ a rate distortion theory as the logical design for this decision making proccess to understand the biochemical processing of information by a cell. Rate distortion theory is also used to design a time dependent Blahut-Arimoto algorithm of three variables where the input is a stimulus vector composed of the time dependent concentrations of three PDT induced signaling molecules and the output reflects a cell fate decision. The concentrations of molecules involved in the biochemical processes are determined by a group of rate equations which produce the probability of cell survival or death as the output of cell decision. The modeling of the cell decision strategy allows quantitative assessment of the cell survival probability, as a function of multiple parameters and coefficients used in the model, which can be modified to account for heterogeneous cell response to PDT or other killing or therapeutic agents. The numerical results show that the present model of type II PDT yields a powerful tool to quantify various processes underlying PDT at the molecular and cellular levels and to interpret experimental results of in vitro cell studies. Finally, following an alternative approach, the cell survival probability is modeled as a predator - prey equation where predators are cell death signaling molecules and prey is the cell survival. The two models can be compared to each other as well as directly to the experimental results of measured molecular concentrations and cell survival ratios for optimization of models, to gain insights on in vitro cell studies of PDT.
Frontiers In Physics 2019 Editor S Choice
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Author : Alex Hansen
language : en
Publisher: Frontiers Media SA
Release Date : 2020-05-19
Frontiers In Physics 2019 Editor S Choice written by Alex Hansen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-19 with categories.
Frontiers in Physics – FPHY – is now in its eighth year. Up to last year, the journal received a slowly increasing trickle of manuscripts, and then during the summer… Boom! The number of manuscripts we receive started increasing exponentially. This is of course a signal to us who are associated with the journal that we are on the right track to build a first-rate journal spanning the entire field of physics. And it is not the only signal. We also see it in other indicators such as the number of views and downloads, Impact Factor and the Cite Score. Should we be surprised at this increase? If I were to describe FPHY in one word, it would be “innovation”. Attaching the names of the reviewers that have endorsed publication permanently to the published paper is certainly in this class. It ensures that the reviewers are accountable; furthermore, the level of transparency this implies ensures that any conflict of interest is detected at the very beginning of the process. The review process itself is innovative. After an initial review that proceeds traditionally, the reviewers and authors enter a back-and-forth dialog that irons out any misunderstanding. The reviewers retain their anonymity throughout the process. The entire review process and any question concerning editorial decisions is fully in the hands of active scientists. The Frontiers staff is not allowed to make any such decision. They oversee the process and make sure that the manuscript and the process leading to publication or rejection upholds the standard. FPHY is of course a gold open access journal. This is the only scientific publication model that is compatible with the information revolution. A journal’s prestige is traditionally associated with how difficult it is to publish there. Exclusivity as criterion for desirability, is a mechanism we know very well from the consumer market. However, is this criterion appropriate for scientific publishing? It is almost by definition not possible to predict the importance of a new idea – otherwise it would not have been new. So, why should journals make decisions on publishing based on predicting the possible importance of a given work. This can only be properly assessed after publication. Frontiers has removed “importance” from the list of criteria for publication. That the work is new, is another matter: the work must be new and scientifically correct. It would seem that removing the criterion of “importance” would be a risky one, but it turns out not to be. The Specialty Chief Editors who lead the 18 sections that constitute FPHY, have made this selection of papers published in FPHY in 2019. We have chosen the papers that we have found most striking. Even though this is far from a random selection, they do give a good idea of what PFHY is about. Enjoy! We certainly did while making this selection. Professor Alex Hansen (Field Chief Editor)
Advances In Photodynamic Therapy
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Author : Michael R. Hamblin
language : en
Publisher: Artech House
Release Date : 2008
Advances In Photodynamic Therapy written by Michael R. Hamblin and has been published by Artech House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
With today's focus on targeted and minimally invasive therapies, photodynamic therapy (PDT) is now being studied and used to combat many disease states and to investigate critical biological questions. This groundbreaking resource brings you the latest advances in photodynamic therapy and offers you a solid understanding of the design, delivery and dosimetry of the three basic ingredients of PDT - photosensitizers, light and oxygen. The book covers novel areas of mechanistic and innovative translational approaches. Moreover, it gives you an overview of the important medical applications of PDT, including approved treatments, clinical trials, and investigated therapies for cancer and non-malignant diseases.
Advanced Healthcare Materials
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Author : Ashutosh Tiwari
language : en
Publisher: John Wiley & Sons
Release Date : 2014-05-09
Advanced Healthcare Materials written by Ashutosh Tiwari and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-09 with Technology & Engineering categories.
Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers
Nanobiomedicine
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Author : Shailendra K. Saxena
language : en
Publisher: Springer Nature
Release Date : 2020-02-03
Nanobiomedicine written by Shailendra K. Saxena and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-03 with Medical categories.
This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology.
Photodynamic Therapy In Dermatology
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Author : Michael H. Gold
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-11
Photodynamic Therapy In Dermatology written by Michael H. Gold and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-11 with Medical categories.
Photodynamic therapy is a proven effective treatment of actinically damaged skin cells, nonmelanoma skin cancers, and acne and other pilosebaceous conditions. As an agent for general facial rejuvenatin it has untapped potential. The current state of PDT therapy and future applications are discussed in detail in this exciting new volume. Throughout, the focus is on evidence-based clinical uses of PDT, including pretreatment regimens, avoidance and management of complications, and posttreatment suggestions.
Tumor Immune Microenvironment In Cancer Progression And Cancer Therapy
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Author : Pawel Kalinski
language : en
Publisher: Springer
Release Date : 2017-12-22
Tumor Immune Microenvironment In Cancer Progression And Cancer Therapy written by Pawel Kalinski and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-22 with Medical categories.
The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
Photodynamic Inactivation Of Microbial Pathogens
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Author : Michael R Hamblin
language : en
Publisher: Royal Society of Chemistry
Release Date : 2011-06-06
Photodynamic Inactivation Of Microbial Pathogens written by Michael R Hamblin and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-06 with Science categories.
Photodynamic therapy (PDT) was discovered over one hundred years ago after observing the death of microorganisms upon exposure to dyes and light. It is the combination of non-toxic dyes and harmless visible light that, in the presence of oxygen, produce highly toxic reactive species. The principal medical application during the last century was in cancer therapy but, in these days of rising antibiotic resistance, PDT shows increasing promise as an alternative approach to treating infections. PDT has also been used in blood product sterilization, peridontology, acne reduction, and the treatment of viral lesions such as those caused by human papilloma virus. It may also have potential as an environmentally friendly pesticide. This is the first and only book to comprehensively cover the use of light and photosensitising agents for controlling microbial pathogens. It provides a comprehensive and up-to-date coverage of an emerging field. There are several chapters on the design of antimicrobial photosensitizers, their use to kill pathogenic organisms and their success in treating infections in animal models. It has long been known that gram-positive bacteria are highly susceptible to photoinactivation but the book also discusses means of widening the range of microorganisms that can be tackled by PDT. Edited by two pioneers in the application of PDT to medical and environmental issues, this book covers the basic science, translational research in animals, and the clinical applications in various medical specialities. It represents an indispensable resource for microbiologists and infectious disease doctors as well as dentists, dermatologists, gastroenterologists and transfusion specialists.
Innovations For Next Generation Antibody Drug Conjugates
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Author : Marc Damelin
language : en
Publisher: Springer
Release Date : 2018-05-29
Innovations For Next Generation Antibody Drug Conjugates written by Marc Damelin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-29 with Medical categories.
Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2003
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.