Mechanism Of Telomerase Inhibition Using Small Inhibitory Rnas And Induction Of Breast Tumor Cell Sensitization
DOWNLOAD
Download Mechanism Of Telomerase Inhibition Using Small Inhibitory Rnas And Induction Of Breast Tumor Cell Sensitization PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Mechanism Of Telomerase Inhibition Using Small Inhibitory Rnas And Induction Of Breast Tumor Cell Sensitization book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Mechanism Of Telomerase Inhibition Using Small Inhibitory Rnas And Induction Of Breast Tumor Cell Sensitization
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2005
Mechanism Of Telomerase Inhibition Using Small Inhibitory Rnas And Induction Of Breast Tumor Cell Sensitization written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Telomerase, a ribonucleoprotein enzyme composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeres after cell divisions and is obligatory for continuous tumor cell proliferation as well as malignant progression of breast cancer cells. Telomerase is an attractive anti-cancer therapeutic agent because telomerase activity is present in over 90% of human breast cancers but is undetectable in most normal somatic cells. Traditional therapies (surgery, chemotherapy, radiotherapy, etc.) lack the ability to effectively control and cure breast cancer, primarily because residual cells are or become resistant to DNA damaging modalities including standard chemo- and radio-therapies. Since telomerase requires its associated hTR for repeat synthesis, we have chosen to use RNA interference as a method to inactivate hTR and hence telomerase. RNA interference (RNAI) has become a powerful tool for the analysis of gene function in that RNAI allows sequence specific inhibition of gene expression. Another protein we targeted is p21, which has long been established as a requirement for senescence. We wanted to further examine its relationship to senescence and apotosis, in an attempt to sensitize breast tumor cells more effectively.
Mechanism Of Telomerase Inhibition Using A Small Inhibitory Rnas And Induction Of Breast Tumor Cell Sensitization
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2007
Mechanism Of Telomerase Inhibition Using A Small Inhibitory Rnas And Induction Of Breast Tumor Cell Sensitization written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Telomerase, a ribonucleoprotein enzyme minimally composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeric repeats onto chromosome ends and is obligatory for continuous tumor cell proliferation, as well as malignant progression of breast cancer cells. Telomerase is an attractive anti-cancer therapeutic target because its activity is present in over 90% of human cancers, including more than 95% of breast carcinomas, but undetectable in most somatic cells. Traditional chemo- and radiotherapies lack the ability to effectively control and cure breast cancer, in part because residual cells are or become resistant to DNA damaging modalities. While various telomerase inhibition strategies cause cancer cells to undergo apoptosis or senescence, there is often a lag period between administration and biologic effect (Corey, 2002). Our goal in this study was to compare the efficacy of different telomerase inhibition strategies in concert with standard chemotherapeutic agents at triggering senescence and/or apoptosis in cultures of breast cancer cells. We hypothesized that telomerase inhibition strategies will sensitize breast cancer cells to traditional chemotherapies, potentially reducing the lag phase, allowing for more potent anti-tumor effects at lower doses, and therefore ultimately imparting less toxicity to the patient.
Mechanism Of Telomerase Inhibition Using Small Inibitory Rnas And Induction Of Breast Tumor Cell Sensitivity
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2007
Mechanism Of Telomerase Inhibition Using Small Inibitory Rnas And Induction Of Breast Tumor Cell Sensitivity written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Telomerase, a ribonucleoprotein enzyme composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeres after cell divisions and is obligatory for continuous tumor cell proliferation as well as malignant progression of breast cancer cells. Telomerase is an attractive anti-cancer therapeutic agent because telomerase activity is present in over 90% of human breast cancers but is undetectable in most normal somatic cells. Traditional therapies (surgery, chemotherapy, radiotherapy, etc.) lack the ability to effectively control and cure breast cancer, primarily because residual cells are or become resistant to DNA damaging modalities including standard chemo- and radio-therapies. Since telomerase requires its associated hTR for repeat synthesis, we have chosen to use RNA interference as a method to inactivate hTR and hence telomerase. RNA interference (RNAi) has become a powerful tool for the analysis of gene function in that RNAi allows sequence specific inhibition of gene expression. Another protein we targeted is p21, which has long been established as a requirement for senescence. We wanted to further examine its relationship to senescence and apotosis, in an attempt to sensitize breast tumor cells more effectively.
Telomeres And Telomerase In Cancer
DOWNLOAD
Author : Keiko Hiyama
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-18
Telomeres And Telomerase In Cancer written by Keiko Hiyama and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-18 with Medical categories.
Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
Systems Biology Of Cancer
DOWNLOAD
Author : Sam Thiagalingam
language : en
Publisher: Cambridge University Press
Release Date : 2015-04-09
Systems Biology Of Cancer written by Sam Thiagalingam and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-09 with Mathematics categories.
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Role Of Nutraceuticals In Cancer Chemosensitization
DOWNLOAD
Author :
language : en
Publisher: Academic Press
Release Date : 2017-10-18
Role Of Nutraceuticals In Cancer Chemosensitization written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-18 with Medical categories.
Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy. Brings updated information on natural compounds used as specific inhibitors of cell signaling pathways as reviewed by experts in the field Presents experts analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches for the readers to use in their own investigations
Heat Shock Proteins In Cancer
DOWNLOAD
Author : Stuart K. Calderwood
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-09
Heat Shock Proteins In Cancer written by Stuart K. Calderwood and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-09 with Medical categories.
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Breast Cancer Biology
DOWNLOAD
Author : Dil Afroze
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-07-08
Breast Cancer Biology written by Dil Afroze and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with Medical categories.
This book offers a comprehensive overview of recent developments in the field of breast cancer biology. It is a complete and descriptive reference on motioning pathways and new treatment options for the future transnational scientists and clinicians working on cancer research and treatment. We greatly appreciate the work of all the contributors to this book. They have brought with them tremendous diversity of perspectives and fields, which is truly reflective of the complexity of the topic, and they have come together in this project to serve as the node of multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information to significantly progress knowledge in the field in recent years.
Gene Therapy For Cancer
DOWNLOAD
Author : Kelly K. Hunt
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-26
Gene Therapy For Cancer written by Kelly K. Hunt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-26 with Medical categories.
The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.
Nanopharmaceuticals Principles And Applications Vol 3
DOWNLOAD
Author : Vinod Kumar Yata
language : en
Publisher: Springer Nature
Release Date : 2020-08-19
Nanopharmaceuticals Principles And Applications Vol 3 written by Vinod Kumar Yata and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-19 with Technology & Engineering categories.
This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
