Mechanisms And New Targets For The Treatment Of Chronic Pain
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Mechanisms And New Targets For The Treatment Of Chronic Pain
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Author : Milica S. Prostran
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-03
Mechanisms And New Targets For The Treatment Of Chronic Pain written by Milica S. Prostran and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-03 with Science categories.
Acute pain has a physiological protective role in preventing tissue damage. However, pain can become chronic due to a multitude of pathophysiological states, such as: trauma, inflammation, neural injury, viral infection, cancer, autoimmune diseases and vascular and metabolic disorders. These pathological states can trigger alterations of the pain pathways that can lead to hypersensitivity, and in such circumstances, pain loses its protective role and instead, becomes persistent and debilitating affecting seriously to the quality of life of patients. Chronic pain is one of the most important health problems worldwide. It has been estimated that 10% of adults are diagnosed with chronic pain each year. However, despite the high prevalence of chronic pain, its management is still no fully satisfactory probably due to the variety of chronic pain conditions with different etiologies (neuropathic, visceral and musculoskeletal pain), and because their pathophysiological mechanisms are only partially known. Therefore, there is a huge need for new effective therapies for the control and/or prevention of the different types of chronic pain. Chronic pain is associated with plastic changes in pain circuits of the peripheral and central nervous system, including changes in the expression of ion channels, neurotransmitters and receptors. In addition, there is growing consensus on non-neuronal mechanisms that can amplify or resolve chronic pain, and cells traditionally thought to act just as coordinators of the inflammatory response (such as immune and glial cells) are now accepted as real modulators of pain signaling. In this regard, animal models of persistent pain, such as models of neuropathic and visceral pain and models of arthritis, are helping to elucidate our understanding of the pathogenesis of chronic pain and make it possible to test experimental treatments.
Pain Therapeutics
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Author : Charlotte Allerton
language : en
Publisher: Royal Society of Chemistry
Release Date : 2014
Pain Therapeutics written by Charlotte Allerton and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Medical categories.
This book presents a contemporary review of the field of pain therapeutics, including the historical medicines which still dominate standard of care treatments, as well as the new mechanisms and combinations/reformulations that have dominated the regulatory approvals over the last decade. In addition this book provides a deep review of the key biological mechanisms currently under investigation for their utility into the treatment of pain, such as ion channels, opiates and others. Additional discussion highlights the current challenges of pain research, covering a range of topics from difficulties in identifying new targets and pre-clinical models to the current regulatory and commercial challenges. This background sets the scene for recent scientific developments in pain research, such as the drive for genetic validation of targets and the derivation of human cell platforms from stem cells. Finally, the book covers the discovery and development stories of two pain products approved in the last decade. These case studies for Lyrica and the Butrans patch, will give insight into the discovery and development challenges and successes for both an oral and non-oral product.
Chronic Pain New Molecular Insights Into Pain And Treatment
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Author : Min Zhuo
language : en
Publisher: World Scientific
Release Date : 2023-09-22
Chronic Pain New Molecular Insights Into Pain And Treatment written by Min Zhuo and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-22 with Science categories.
This book successfully explores cellular and molecular mechanisms of chronic pain based on recent basic neurobiological investigations. By focusing on major breakthroughs in basic neurosciences, it is believed to contain the promise for future new pain drug discovery.Instead of repeating extensive reviews of basic animal and clinical observations, the book provides a novel neuronal model that is believed to be the key target for treating chronic pain. In addition, it reviews and validates animal models developed for studying basic mechanisms of pain and chronic pain, and the current medicine used to treat chronic pain as well as alternative pain treatment. The final few chapters also cover how pain may interfere with other high brain functions, such as fear, anxiety, sleep, memory, etc.
Advances In Pain Research Mechanisms And Modulation Of Chronic Pain
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Author : Bai-Chuang Shyu
language : en
Publisher: Springer
Release Date : 2018-10-10
Advances In Pain Research Mechanisms And Modulation Of Chronic Pain written by Bai-Chuang Shyu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-10 with Medical categories.
This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017. Founded in Kyoto, Japan in 2000, the APS serves as a platform for scientists to present recent findings in pain research and discuss research orientation in this field. APS 2017 focused on novel strategies for pain treatment. Written by experts from various disciplines, from molecular to functional, and from basic to clinic studies, this book is composed of 18 review articles on the physiology and pathology of pain in these research fields. Specific topics include circuitry, neurotransmitter, physiology, behavior, neuropathology, pharmacology, and the treatments for neuropathic pain disorders. The book is a valuable resource for researchers and graduate students in pain medicine and neuroscience.
Novel Molecular Targets For The Treatment Of Pain
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Author : Tally Largent-Milnes
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-02
Novel Molecular Targets For The Treatment Of Pain written by Tally Largent-Milnes and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-02 with Science categories.
Topic Editor John Streicher is a co-founder and equity partner of Teleport Pharmaceuticals, LLC. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Spinal Cord Injury Pain
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Author : Christine N. Sang
language : en
Publisher: Elsevier
Release Date : 2021-10-21
Spinal Cord Injury Pain written by Christine N. Sang and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-21 with Medical categories.
Spinal Cord Injury Pain presents the basis for preclinical and clinical investigations, along with strategies for new approaches in the treatment of central neuropathic pain. Contributors from the private sector and academia provide a comprehensive review of state-of-the-art research in this challenging space. Topics include Epidemiology of Chronic Pain Following SCI, experimental models and mechanisms of chronic pain in SCI, and new targets and technologies. This book serves as a resource for continued translational research that will result in novel approaches and treatments that improve function and quality of life for individuals with CNP/SCI. Despite a better understanding of the complexity of mechanisms of CNP/SCI, improved medical and surgical management of SCI, and the subsequent acceleration of the identification of new targets and the development of novel analgesics, there is still a great unmet clinical need in the area of CNP following SCI. Hence, this book is a welcomed addition to current research and developments. Provides a comprehensive resource for novel approaches and treatments that improve function and quality of life for individuals with CNP/SCI Includes contributors from the private sector and academia Covers epidemiology of chronic pain following SCI, experimental models, mechanisms of chronic pain in SCI, and new targets and technologies
Mechanisms Of Vascular Disease
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Author : Robert Fitridge
language : en
Publisher: University of Adelaide Press
Release Date : 2011
Mechanisms Of Vascular Disease written by Robert Fitridge and has been published by University of Adelaide Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Practical Management Of Pain
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Author : Honorio Benzon
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-02-10
Practical Management Of Pain written by Honorio Benzon and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-10 with Medical categories.
For more than 30 years, Practical Management of Pain has offered expert guidance to both clinicians and trainees, covering every aspect of acute and chronic pain medicine for adult and pediatric patients. The fully revised 6th Edition brings you fully up to date with new developments in patient evaluation, diagnosis of pain syndromes, rationales for management, treatment modalities, and much more. Edited by a team of renowned pain clinicians led by Dr. Honorio Benzon, this authoritative reference is a comprehensive, practical resource for pain diagnosis and treatment using a variety of pharmacologic and physical modalities. Presents a wealth of information in a clearly written, easily accessible manner, enabling you to effectively assess and draw up an optimal treatment plan for patients with acute or chronic pain. Takes a practical, multidisciplinary approach, making key concepts and techniques easier to apply to everyday practice. Shares the knowledge and expertise of global contributors on all facets of pain management, from general principles to specific management techniques. Discusses the latest, best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents such as topical analgesics. Covers recent global developments regarding opioid induced hyperalgesia, neuromodulation and pain management, and identification of specific targets for molecular based pain. Includes current information on the use of cannabinoids in pain management and related regulatory, professional, and legal considerations. Includes the latest guidelines on facet injections and safety of contrast agents. Provides new, evidence-based critical analysis on treatment modality outcomes and the latest information on chronic pain as a result of surgical interventions.
Hyperalgesia And Allodynia
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Author : Merab G. Tsagareli, Ph.d.
language : en
Publisher:
Release Date : 2018-12-26
Hyperalgesia And Allodynia written by Merab G. Tsagareli, Ph.d. and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-26 with categories.
Pain and itch are associated with a wide range of injuries and diseases. Some conditions may have pain and associated symptoms arising from a discrete cause, such as postoperative and neuropathic pains or headaches. Chronic itch or pruritus is a frequent symptom in the general population and in many skin and systemic diseases. Millions of people on the planet suffer from acute or chronic pain and itch every year, and the effects of pain and itch exact a tremendous cost on most countries concerning health care costs, rehabilitation and lost worker productivity, as well as the emotional and financial burden it places on patients and their families. Therefore, the synthesis and development of a new generation of analgesic drugs with lesser side effects are very important for society.This book provides an original account of behavioral, cellular and molecular aspects with important ramifications for the study of hyperalgesia and allodynia in pain and itch. It concentrates on the role of transient receptor potential (TRP) channels functioning in pain and itch states. It explains how TRP channels work in terms of specified somato-sensory mechanisms and systems. This book shows that TRP channels are promising targets for the development of a new group of analgesic drugs at the periphery and central levels and opportunities for therapeutic intervention.
Synaptic Plasticity In Pain
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Author : Marzia Malcangio
language : en
Publisher: Springer
Release Date : 2014-11-29
Synaptic Plasticity In Pain written by Marzia Malcangio and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-29 with Medical categories.
Primary sensory neurons respond to peripheral stimulation and project to the spinal cord. Specifically, the population of neurons which respond to damaging stimuli terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second order neurons. It has recently become clear that the strength of this first pain synapse is plastic and modifiable by several modulators, including neuronal and non-neuronal regulators, and studies on the fundamental processes regulating the plasticity of the first pain synapse have resulted in the identification of new targets for the treatment of chronic pain. This book will be of interest to a wide readership in the pain field.