Mechanisms In Parkinson S Disease
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Mechanisms In Parkinson S Disease
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Author : Juliana Dushanova
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-02-08
Mechanisms In Parkinson S Disease written by Juliana Dushanova and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-08 with Medical categories.
Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction, and oxidative stress may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cascade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
Noradrenergic Mechanisms In Parkinson S Disease
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Author : Mike Briley
language : en
Publisher: CRC Press
Release Date : 1993-12-16
Noradrenergic Mechanisms In Parkinson S Disease written by Mike Briley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-12-16 with Science categories.
Noradrenergic Mechanisms in Parkinson's Disease examines fundamental and clinical evidence explaining the progression of the disease. Featuring contributions from acknowledged international experts in the field, this book defines ideopathic Parkinson's disease and covers such topics as the alterations in Parkinson's disease, norepinephrine-dopamine interactions, noradrenergic control of striatal dopamine release, glial cells as targets of the central noradrenergic systems, and a theory regarding noradrenergic mechanisms in Parkinson's disease. New directions for research on Parkinson's disease are also explored.
Mechanisms Of Cell Death And Approaches To Neuroprotection Disease Modification In Parkinson S Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-11-10
Mechanisms Of Cell Death And Approaches To Neuroprotection Disease Modification In Parkinson S Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-10 with Science categories.
Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease explores the results of numerous studies surrounding in vitro and animal model evidence that looks at the impact of a-synucleinopathy on neuronal dysfunction and behavioral impairments, (ii) how research in animal models supports the development of therapeutic strategies, and (iii) how findings in animal models might relate to the disease process in humans. In this book, the author's shed light upon the complex scenario of the mechanisms of cell death and approaches to neuroprotection/disease modification in PD, both in vitro to in vivo. Along with degeneration, the pathological hallmark of PD is the presence of intraneuronal proteinaceous cytoplasmic inclusions, named Lewy Bodies (LB) that invade the whole nervous system as the disease progresses. Several fundamental discoveries have shed light upon the implication of the a-syn protein in the pathogenesis of familial and sporadic forms of PD. Other proteins also accumulate in LB, but a-syn is a major protein component of the pathological landmarks. Updates on the latest research surrounding Mechanisms of Cell Death in Parkinson’s Disease Includes In vitro and In vivo models of synucleinopathy Presents therapeutic strategies in Parkinson’s Disease
Etiology Of Parkinson S Disease
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Author : Jonas H. Ellenberg
language : en
Publisher: CRC Press
Release Date : 1995-03-01
Etiology Of Parkinson S Disease written by Jonas H. Ellenberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-01 with Medical categories.
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Parkinson S Disease
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Author : Patrik Verstreken
language : en
Publisher: Academic Press
Release Date : 2016-12-19
Parkinson S Disease written by Patrik Verstreken and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-19 with Medical categories.
Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease
Parkinson S Disease Cell Vulnerability And Disease Progression
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Author : Javier Blesa
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-04
Parkinson S Disease Cell Vulnerability And Disease Progression written by Javier Blesa and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-04 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Download PDF Download EPUB Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease.
Molecular Mechanisms Of Parkinson S Disease
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Author : Philipp Kahle
language : en
Publisher: Eurekah.Com Incorporated
Release Date : 2003
Molecular Mechanisms Of Parkinson S Disease written by Philipp Kahle and has been published by Eurekah.Com Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
Balance Dysfunction In Parkinson S Disease
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Author : Martina Mancini
language : en
Publisher: Academic Press
Release Date : 2019-09-14
Balance Dysfunction In Parkinson S Disease written by Martina Mancini and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-14 with Medical categories.
Balance Dysfunction in Parkinson’s Disease: Basic Mechanisms to Clinical Management presents the most updated information on a variety of topics. Sections help clinicians evaluate the types of balance control issues, dynamic balance dysfunction during turning, and the effects of medication, deep brain stimulation, and rehabilitation intervention on balance control. This book is the first to review the four main postural control systems and how they are affected, including balance during quiet stance, reactive postural adjustments to external perturbations, anticipatory postural adjustments in preparation for voluntary movements, and dynamic balance control during walking and turning. In addition, the book's authors summarize the effects of levodopa, deep brain stimulation, and rehabilitation intervention for each balance domain. This book is recommended for anyone interested in how and why balance control is affected by PD. Provides the first comprehensive review of research to date on balance dysfunctions in Parkinson's disease Discusses how to translate current neuroscience research into practice regarding neural control of balance Provides evidence on the effects of current interventions on balance control
Pathogenetic Mechanisms In Parkinson S Disease
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Author : Anna L. Bartels
language : en
Publisher:
Release Date : 2010
Pathogenetic Mechanisms In Parkinson S Disease written by Anna L. Bartels and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Recent Advances In Parkinsons Disease
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Author :
language : en
Publisher: Elsevier
Release Date : 2010-09-29
Recent Advances In Parkinsons Disease written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-29 with Medical categories.
This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist