Noradrenergic Mechanisms In Parkinson S Disease
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Noradrenergic Mechanisms In Parkinson S Disease
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Author : Mike Briley
language : en
Publisher: CRC Press
Release Date : 1993-12-16
Noradrenergic Mechanisms In Parkinson S Disease written by Mike Briley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-12-16 with Science categories.
Noradrenergic Mechanisms in Parkinson's Disease examines fundamental and clinical evidence explaining the progression of the disease. Featuring contributions from acknowledged international experts in the field, this book defines ideopathic Parkinson's disease and covers such topics as the alterations in Parkinson's disease, norepinephrine-dopamine interactions, noradrenergic control of striatal dopamine release, glial cells as targets of the central noradrenergic systems, and a theory regarding noradrenergic mechanisms in Parkinson's disease. New directions for research on Parkinson's disease are also explored.
Mechanisms In Parkinson S Disease
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Author : Juliana Dushanova
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-02-08
Mechanisms In Parkinson S Disease written by Juliana Dushanova and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-08 with Medical categories.
Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction, and oxidative stress may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cascade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
Non Dopaminergic Systems In Parkinson S Disease
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Author : Cristina Miguelez
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-02
Non Dopaminergic Systems In Parkinson S Disease written by Cristina Miguelez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-02 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Etiology Of Parkinson S Disease
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Author : Jonas H. Ellenberg
language : en
Publisher: CRC Press
Release Date : 1995-03-01
Etiology Of Parkinson S Disease written by Jonas H. Ellenberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-01 with Medical categories.
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Dopaminergic Mechanisms
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Author : Donald Brian Calne
language : en
Publisher:
Release Date : 1975
Dopaminergic Mechanisms written by Donald Brian Calne and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Dopamine categories.
Parkinson S Disease From Clinical Aspects To Molecular Basis
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Author : Toshiharu Nagatsu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Parkinson S Disease From Clinical Aspects To Molecular Basis written by Toshiharu Nagatsu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This b00k reviews the recent advances in the research on Parkinson's disease. It contains review articles from basic to clinical researches including the historical introduction and the molecular biological approach to Parkinson's disease. Parkinson's disease is the most representative, age-related neurodegenerative disease. It is clinically characterized by movement disorders such as muscle rigidity, akinesia and tremor. The elucidation of its biochemical and molecular mechanisms has rapidly been progressing and is expected to contribute to the understanding of normal brain aging in general. This project is supported by a Grant-in-Aid for Scientific Research on Priority Areas, "Molecular Biology of the Motor System", Ministry of Education, Science and Culture, Japan, for 3 years from 1987 to 1989. We are grateful for the support. These reviews are a part of the works which have been supported by this Grant-in-Aid. The characteristics of this research project on Parkinson's disease are interdisciplinary approach from basic, molecular biology to clinical medicine, and the molecular biological approach is expected to be the most promising for the elucidation of the pathogenesis. The collaboration and discussion between basic and clinical researchers in this Priority Area Project has been efficient and productive. We hope that this book can mark another new milestone in the studies on Park,oson's disease and in neuroscience. We are very grateful to Nippon Schering for their generous support for the publication of this book. Last but not least, we thank Springer-Verlag Wien New York for the excellent production of this book and the excellent cooperation.
L Dopa And Parkinsonism
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Author : André Barbeau
language : en
Publisher: Philadelphia : F. A. Davis Company
Release Date : 1970
L Dopa And Parkinsonism written by André Barbeau and has been published by Philadelphia : F. A. Davis Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Dopa categories.
Mechanisms Of Cell Death And Approaches To Neuroprotection Disease Modification In Parkinson S Disease
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Author :
language : en
Publisher: Elsevier
Release Date : 2021-11-12
Mechanisms Of Cell Death And Approaches To Neuroprotection Disease Modification In Parkinson S Disease written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-12 with Medical categories.
Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson's Disease explores the results of numerous studies surrounding in vitro and animal model evidence that looks at the impact of a-synucleinopathy on neuronal dysfunction and behavioral impairments, (ii) how research in animal models supports the development of therapeutic strategies, and (iii) how findings in animal models might relate to the disease process in humans. In this book, the author's shed light upon the complex scenario of the mechanisms of cell death and approaches to neuroprotection/disease modification in PD, both in vitro to in vivo. Along with degeneration, the pathological hallmark of PD is the presence of intraneuronal proteinaceous cytoplasmic inclusions, named Lewy Bodies (LB) that invade the whole nervous system as the disease progresses. Several fundamental discoveries have shed light upon the implication of the a-syn protein in the pathogenesis of familial and sporadic forms of PD. Other proteins also accumulate in LB, but a-syn is a major protein component of the pathological landmarks. Updates on the latest research surrounding Mechanisms of Cell Death in Parkinson's Disease Includes In vitro and In vivo models of synucleinopathy Presents therapeutic strategies in Parkinson's Disease
Homeostatic Control Of Brain Function
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Author : Detlev Boison
language : en
Publisher: Oxford University Press
Release Date : 2016
Homeostatic Control Of Brain Function written by Detlev Boison and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.
Psychiatry Of Parkinson S Disease
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Author : K.P. Ebmeier
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2012-01-06
Psychiatry Of Parkinson S Disease written by K.P. Ebmeier and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-06 with Medical categories.
Psychiatric symptoms are common in the neurological and geriatric care of patients with Parkinson’s disease. This book assembles short reviews from experts in the field to chart the various psychiatric syndromes known in Parkinson’s disease, their presentation, etiology and management. Presented are special topics on epidemiology of psychiatric symptoms, affective disorders and apathy, early cognitive impairment through to dementia, visuoperceptual dysfunction, psychotic disorders, sleep disturbances, impulse disorders and sexual problems. Further, rarely discussed issues, such as the relationship between somatoform disorders and parkinsonism are reviewed. This publication is essential reading for old age psychiatrists, gerontologists and neurologists who work with patients suffering from Parkinson’s disease. In addition, health practitioners who deal with senior patients, as well as scientists who need a quick update on the progress in this important clinical field will find this volume a helpful reference.
