Parkinson S Disease From Clinical Aspects To Molecular Basis
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Parkinson S Disease From Clinical Aspects To Molecular Basis
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Author : Toshiharu Nagatsu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Parkinson S Disease From Clinical Aspects To Molecular Basis written by Toshiharu Nagatsu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This b00k reviews the recent advances in the research on Parkinson's disease. It contains review articles from basic to clinical researches including the historical introduction and the molecular biological approach to Parkinson's disease. Parkinson's disease is the most representative, age-related neurodegenerative disease. It is clinically characterized by movement disorders such as muscle rigidity, akinesia and tremor. The elucidation of its biochemical and molecular mechanisms has rapidly been progressing and is expected to contribute to the understanding of normal brain aging in general. This project is supported by a Grant-in-Aid for Scientific Research on Priority Areas, "Molecular Biology of the Motor System", Ministry of Education, Science and Culture, Japan, for 3 years from 1987 to 1989. We are grateful for the support. These reviews are a part of the works which have been supported by this Grant-in-Aid. The characteristics of this research project on Parkinson's disease are interdisciplinary approach from basic, molecular biology to clinical medicine, and the molecular biological approach is expected to be the most promising for the elucidation of the pathogenesis. The collaboration and discussion between basic and clinical researchers in this Priority Area Project has been efficient and productive. We hope that this book can mark another new milestone in the studies on Park,oson's disease and in neuroscience. We are very grateful to Nippon Schering for their generous support for the publication of this book. Last but not least, we thank Springer-Verlag Wien New York for the excellent production of this book and the excellent cooperation.
Parkinson S Disease
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Author : Toshiharu Nagatsu
language : en
Publisher: Springer Verlag
Release Date : 1991
Parkinson S Disease written by Toshiharu Nagatsu and has been published by Springer Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Brain categories.
Parkinson S Disease From Clinical Aspects To Molecular Basis
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Author : John Stewart
language : en
Publisher: American Medical Publishers
Release Date : 2023-09-19
Parkinson S Disease From Clinical Aspects To Molecular Basis written by John Stewart and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-19 with Medical categories.
Parkinson's disease (PD) refers to a type of long-term degenerative disorder of the central nervous system which primarily impacts the motor system. It is clinically categorized through movement disorders, including tremor, muscular stiffness and akinesia. The study of its molecular and biochemical mechanisms aids in better understanding of the normal brain ageing. The cause of PD is still unknown, but both environmental and inherited factors are assumed to have a role in the disease. A separate set of genes whose dysfunctional regulation is significantly linked to the disease. These genes comprise DJ-1, ATP13A2, alpha-synuclein, PTEN induced putative kinase 1 (PINK1), leucine rich repeat kinase 2 (LRRK2) and parkin. In clinical practice, a range of medications are utilized for treating PD, the majority of which work by raising dopamine levels in the midbrain. This book provides significant information to help develop a good understanding of Parkinson's disease. It aims to shed light on clinical aspects and molecular basis of this disease. This book will serve as a reference to a broad spectrum of readers.
Parkinson S Disease
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Author : Patrik Verstreken
language : en
Publisher: Academic Press
Release Date : 2016-12-19
Parkinson S Disease written by Patrik Verstreken and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-19 with Science categories.
Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease
Recent Advances In Parkinson S Disease
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Author :
language : en
Publisher: Elsevier
Release Date : 2020-04-16
Recent Advances In Parkinson S Disease written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-16 with Science categories.
Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more. Covers all key aspects of current research on Parkinson ́s disease Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches Presents articles authored by world leaders in their respective fields
Etiology Of Parkinson S Disease
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Author : Jonas H. Ellenberg
language : en
Publisher: CRC Press
Release Date : 1995-03-01
Etiology Of Parkinson S Disease written by Jonas H. Ellenberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-01 with Medical categories.
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Neurodegenerative Diseases
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Author : Daniela Galimberti
language : en
Publisher:
Release Date : 2018
Neurodegenerative Diseases written by Daniela Galimberti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Nervous system categories.
This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, Lewy body dementia, Parkinson's disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
The Metabolic And Molecular Basis Of Acquired Disease
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Author : R. D. Cohen
language : en
Publisher:
Release Date : 1990
The Metabolic And Molecular Basis Of Acquired Disease written by R. D. Cohen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Cells categories.
The Molecular And Cellular Basis Of Neurodegenerative Diseases
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Author : Michael S. Wolfe
language : en
Publisher: Academic Press
Release Date : 2018-03-29
The Molecular And Cellular Basis Of Neurodegenerative Diseases written by Michael S. Wolfe and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-29 with Medical categories.
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts
Encyclopedia Of Movement Disorders
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-02-26
Encyclopedia Of Movement Disorders written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-26 with Science categories.
The Encyclopedia of Movement Disorders is a comprehensive reference work on movement disorders, encompassing a wide variety of topics in neurology, neurosurgery, psychiatry and pharmacology. This compilation will feature more than 300 focused entries, including sections on different disease states, pathophysiology, epidemiology, genetics, clinical presentation, diagnostic tools, as well as discussions on relevant basic science topics. This Encyclopedia is an essential addition to any collection, written to be accessible for both the clinical and non-clinical reader. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in the laboratory to the clinical features, pathophysiology and treatment of movement disorders. The Encyclopedia targets a broad readership, ranging from students to general physicians, basic scientists and Movement Disorder specialists. Published both in print and via Elsevier’s online platform of Science Direct, this Encyclopedia will have the enhanced option of integrating traditional print with online multimedia. Connects experimental findings made in the laboratory to the clinical features, pathophysiology, and treatment of movement disorders Encompasses a wide variety of topics in neurology neurosurgery, psychiatry, and pharmacology Written for a broad readership ranging from students to general physicians, basic scientists, and movement disorder specialists
