Mechanisms Of Chemical Carcinogenesis
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Mechanisms Of Chemical Carcinogenesis
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Author : D. E. Hathway
language : en
Publisher: Butterworth-Heinemann
Release Date : 2013-10-22
Mechanisms Of Chemical Carcinogenesis written by D. E. Hathway and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Mechanisms of Chemical Carcinogenesis provides information pertinent to the fundamental mechanisms of chemical carcinogenesis. This book surveys the interactions of chemical carcinogens with native DNA, the activation of normal cellular sequences, and the transforming role of the activated genes. Organized into seven chapters, this book begins with an overview of the relationship between the incidence of lung cancer and the frequency and duration of cigarette smoking. This text then examines the concept that carcinogens may require metabolic activation before they initiate carcinogenesis. Other chapters consider the structure of the nucleoside adducts resulting from the hydrolysis of salmon-sperm DNA and rat-liver ribosomal RNA. This book discusses as well the persistence of nucleoside analogues in target-tissue nucleic acid. The final chapter deals with mutational theory. This book is a valuable resource for workers involved with cancer research, toxicology, and molecular biology. Specialists in drug development, industrial hygiene and occupational medicine will also find this book useful.
Carcinogens Dna Damage And Cancer Risk Mechanisms Of Chemical Carcinogenesis
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Author : Miriam Christine Poirier
language : en
Publisher: World Scientific
Release Date : 2018-09-28
Carcinogens Dna Damage And Cancer Risk Mechanisms Of Chemical Carcinogenesis written by Miriam Christine Poirier and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-28 with Medical categories.
As chemical exposures and cancer rates increase worldwide, there is a need for students, researchers, public health professionals, and physicians to understand the mechanisms connecting exposure with human cancer risk. This new book is an essential reference, as well as introduction to the field of chemical carcinogenesis, with particular focus on DNA damage as a critical link between exposure and disease, and emphasis on biomarkers associated with cancer risk in humans. In addition to DNA damage, related topics covered include metabolism of selected chemical carcinogens, exposure-induced epigenetic changes, cancer-associated mutations and reduction of DNA damage and cancer risk by chemoprevention. The book is designed to be a comprehensive guide to basic principles, a teaching tool for academics, and a map for the development of protective mechanisms to reduce human cancer risk.
Chemical Carcinogenesis
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Author : Francisco Feo
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Chemical Carcinogenesis written by Francisco Feo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.
Chemical Carcinogenesis
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Author : Francesco Feo
language : en
Publisher: Springer
Release Date : 1988
Chemical Carcinogenesis written by Francesco Feo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Science categories.
About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.
Mechanisms Of Chemical Carcinogenesis And Their Impact On Dose Response Relationships
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Author : Cornelia Gericke
language : en
Publisher:
Release Date : 2008
Mechanisms Of Chemical Carcinogenesis And Their Impact On Dose Response Relationships written by Cornelia Gericke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Mechanisms Of Carcinogenesis
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Author : Elizabeth K. Weisburger
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mechanisms Of Carcinogenesis written by Elizabeth K. Weisburger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.
Chemical Carcinogens
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Author : Peter Politzer
language : en
Publisher: Elsevier Publishing Company
Release Date : 1988
Chemical Carcinogens written by Peter Politzer and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.
Since 1978, annual Interdisciplinary Cancer Research Workshops have been held at the University of New Orleans. In 1987 it seemed appropriate to consider an extended publication that would mark the completion of the first decade of these meetings. This volume is the result. A number of the distinguished researchers who participated in the first ten workshops have contributed chapters summarizing their current work in the area of chemical carcinogenesis. These contributions cover a wide range of topics, are particularly up-to-date, and reflect a consistently high level of scientific investigation which will both inform and stimulate all those currently active in - or entering some area of - cancer research.
Mechanisms Of Carcinogenesis In Risk Identification
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Author : Harri Vainio
language : en
Publisher:
Release Date : 1992
Mechanisms Of Carcinogenesis In Risk Identification written by Harri Vainio and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
This comprehensive, authoritative volume includes a consensus document drawn up by a working group of international experts in various fields of carcinogenesis. It describes the multistage and multifactorial nature of carcinogenesis, the different mechanisms of action of carcinogens, epidemiological and laboratory means for their identification, and proposed principles and procedures for their possible use in the prediction and evaluation of carcinogenic risks to humans. Other chapters cover critical molecular targets in chemical carcinogenesis; mechanisms of carcinogenicity; animal carcinogenicity tests and their interpretations; biological markers in exposed humans; and data analysis and modelling. This work will be a valuable reference for cancer researchers and toxicologists.
Chemical Carcinogenesis
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Author : Trevor M. Penning
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-03-03
Chemical Carcinogenesis written by Trevor M. Penning and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-03 with Medical categories.
This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Biochemistry Of Chemical Carcinogenesis
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Author : R. Colin Garner
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biochemistry Of Chemical Carcinogenesis written by R. Colin Garner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.