Mechanisms Of Endothelium Dependant Dilation

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Mechanisms Of Endothelium Dependant Dilation

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Author : Sharmila Deepa Chauhan
language : en
Publisher:
Release Date : 2003

Mechanisms Of Endothelium Dependant Dilation written by Sharmila Deepa Chauhan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.

Mechanisms And Functional Impact Of Impaired Endothelium Dependent Dilation In Coronary Resistance Arteries From Hypertensive Rats

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Author : Kathryn M. Gauthier
language : en
Publisher:
Release Date : 1998

Mechanisms And Functional Impact Of Impaired Endothelium Dependent Dilation In Coronary Resistance Arteries From Hypertensive Rats written by Kathryn M. Gauthier and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.

The Endothelium

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Author : Michel Félétou
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2011

The Endothelium written by Michel Félétou and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Science categories.

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Flow Dependent Regulation Of Vascular Function

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Author : John A Bevan
language : en
Publisher: Springer
Release Date : 2013-05-27

Flow Dependent Regulation Of Vascular Function written by John A Bevan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-27 with Science categories.

Exactly sixty years ago Schretzenmayer provided the first experimental proof that changes in blood ftow can affect the diameter oflarge arteries. Since then, support has been growing for the idea that intraluminal blood ftow plays an important role in regulating not only the tone of blood vessels, but also their caliber and structure. Investigations of the&e phenomena have been given a strong impetus by the discovery that the endothelium can modulate the tone of underlying vascular smooth muscle via the release of a number of vasoactive substances. Investigators often diverge in their opinions regarding the nature of the vascular wall response to blood ftow and the mechanisms involved. This book is the first summary of our state of knowledge and the nature of the research carried out on ftow-related changes. Early chapters review involvement of shear-stress-dependent events in the circulation as a whole. They cover the biophysical principles of ftuid transport, the cellular signal transduction path ways, and the molecular biology and biochemistry of ftow-induced changes in endothelial cells. Later chapters provide an in-depth summary of the regula tion of vascular muscle tone by ftow. They include historical perspectives, evi dence that ftow-induced vasodilation is primarily endothelium-dependent and that it can induce constriction, and details on ftow-dependent regulation in regional vascular beds. Several chapters emphasize the endothelial activation by shear stress and its importance in the control offtow in the microcirculation.

Endothelial Mechanisms Of Vasomotor Control

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Author : H. Drexler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Endothelial Mechanisms Of Vasomotor Control written by H. Drexler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

In recent years, we have witnessed a rapid expansion of our knowledge regarding the role of the endothelium in the control of vascular tone (and organ perfusion) in health and disease. Physiology, pharmacology, and molecular biology have uncovered a wealth of information on structure and function of this heretofore largely neglected "organ". Clinical medicine is now called upon to define the clinical significance of these observa tions that imply the mechanisms of blood coagulation, e.g., the interaction of throm bocytes with the endothelium, vasomotor control, and specifically, the regulation of smooth muscle tone with consequences for vascular resistance and conductance and organ blood flow. Finally, metabolism of lipids with the everlasting problem of athero sclerosis is an important aspect. In a second step, implications regarding the improvement of current therapeutic con cepts, as well as the development of new modalities of pharmacotherapy will have to be discussed. The topic addressed by the 1990 Gargellen Conference: Endothelial Mechanisms of Vasomotor Control, clearly is of interest for both basic scientists and clinicians. It has been the aim of the organizers, the Society for Cooperation in Medical Science (SCMS) with this and the previous symposia to foster and support both basic science and clinical research. Research in medicine today shows two major directions of development: on the one hand, increasing involvement of the basic sciences and their methodology. On the other hand, statistical validation of concepts and therapeutic strategies in large scale population-and multicenter-studies.

Endothelium

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Author :
language : en
Publisher: Academic Press
Release Date : 2016-07-20

Endothelium written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-20 with Science categories.

Endothelium, the new volume in the Advances in Pharmacology series, presents readers with a variety of chapters that cover various endothelium-derived mediators and their changes with gender, and during vascular development, senescence, and hypertensive disorders. Topics include endothelium, nitric oxide, gap junctions, potassium channels, endothelin, vascular development, vascular permeability, gender, aging, and preeclampsia. With contributions from the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Contains contributions from the best authors in the field Provides an essential resource for pharmacologists, immunologists, and biochemists Covers endothelium-derived mediators and their changes

A Device To Study The Mechanism Of Flow Dependent Dilation The Effects Of Shear Stress And Endothelium Derived Relaxing Factor

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Author : Christina I. Kimmel
language : en
Publisher:
Release Date : 1988

A Device To Study The Mechanism Of Flow Dependent Dilation The Effects Of Shear Stress And Endothelium Derived Relaxing Factor written by Christina I. Kimmel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with categories.

Endothelial Dysfunctions And Vascular Disease

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Author : Raffaele De Caterina
language : en
Publisher: Wiley-Blackwell
Release Date : 2007-04-24

Endothelial Dysfunctions And Vascular Disease written by Raffaele De Caterina and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-24 with Medical categories.

Bridging the gap between the laboratory and the bedside, this timely volume illuminates the connection between endothelial dysfunction and vascular disease. This comprehensive survey of atherosclerotic disease begins with biology – incorporating the latest breakthroughs in the field – then elucidates risk factors and diagnostic tools and markers. A major section on endothelium-directed prevention and therapy shows you how to apply cutting-edge research to clinical care. Under the careful editorial guidance of Drs. De Caterina and Libby, the highly-regarded contributors address: - endothelial activation and the initiation of atherosclerosis - mechanisms of plaque progression and complications - the role of LDL in the origin and progression of atherosclerosis - advanced glycation endproducts and the accelerated atherosclerosis in diabetes - oxidative stress and vascular disease - soluble adhesion molecules as markers of vascular disease - hormone-replacement therapy and cardiovascular risk - anti-oxidants and endothelial protection and more. The first book dedicated to the central role of endothelial dysfunction in vascular disease, this concise volume gathers all the latest information on the subject into one convenient and cohesive text. Make sure your patients are benefiting from current knowledge by keeping a copy of Enothelial Dysfunctions in Vascular Disease close at hand for frequent consultation. Introduction Every book has a history, this one not excepted, having emerged from intersections in professional lives of the Editors. This book bears the fruits of a collaboration between the “pupil” (RDC) and the “mentor” (PL). During an extended sabbatical of the pupil in Boston in 1994, we probed together the concept that endothelial dysfunction served as a common denominator of vascular disease, with the balance between inflammation and its inhibition as a fulcrum of the regulation of the behavior of endothelial cells. As practicing cardiologists in our clinical lives, we sought to link to endothelial function the mechanisms of action of risk factors and of pharmacologic agents used to treat and prevent vascular disease. The pupil therefore authored a few reviews on the mechanism of action of risk factors and included them in a small book, published in Italian, for which the mentor wrote a preface. The book was greeted with favor from the Italian cardiological community, and provided the nidus for the present, more ambitious endeavor, which includes updated reviews on the pathogenesis of vascular disease and on the most novel aspects of vascular biology. This enterprise was enabled by the contributions of many of our former or present collaborators and colleagues, without whose enthusiasm and engagement this work could never have seen light. We largely underestimated the devotion necessary on our own side at the beginning, but it ultimately yielded a product that we feel achieves our original goals. We are aware that we confront a continuously evolving topic, where frequent updates would be desirable - if not necessary. Yet, we believe in the value of books - such as the current one - that attempt to organize in a snapshot of time, the vast amount of literature available in a coherent and comprehensive scheme. We are aware of existing gaps, of emerging material not paid its due, and of the rapid evolution of some of the concepts highlighted within. The links between the laboratory and the clinic have never afforded more opportunity for new understanding and advances in diagnosis and treatment than today We hope that our colleagues, vascular biologists cardiologists, internists, and other physicians alike will find this compendium a useful guide to this most exciting time in vascular biology and medicine Raffaele De Caterina and Peter Libby

Endothelium Dependent Vasodilation Methods And Mechanisms In Humans

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Author : Adriaan Maarten Kamper
language : en
Publisher:
Release Date : 2004

Endothelium Dependent Vasodilation Methods And Mechanisms In Humans written by Adriaan Maarten Kamper and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.

Mechanisms Of Vascular Disease

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Author : Robert Fitridge
language : en
Publisher: University of Adelaide Press
Release Date : 2011

Mechanisms Of Vascular Disease written by Robert Fitridge and has been published by University of Adelaide Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.