Mechanisms Of Injury In Renal Disease And Toxicity
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Mechanisms Of Injury In Renal Disease And Toxicity
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Author : Robin S. Goldstein
language : en
Publisher: CRC Press
Release Date : 2020-11-25
Mechanisms Of Injury In Renal Disease And Toxicity written by Robin S. Goldstein and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-25 with Medical categories.
Dr. Goldstein has authored more than 50 publications and co-edited two books. Her latest contribution to the field of nephrology, Mechanisms of Injury in Renal Disease and Toxicity, promotes an understanding of the pathophysiologic mechanisms mediating renal dysfunction in disease. It provides an important perspective in understanding mechanisms of chemically induced renal injury. Over the past decade, understanding of the pathophysiologic and molecular basis of renal disease has grown tremendously. New and evolving concepts on the pathophysiology of glomerulonephritis, chronic glomerular injury, diabetic nephropathy, and acute renal failure are changing the clinical management of these disease states.
Toxicology Of The Kidney
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Author : Joan B Tarloff
language : en
Publisher: CRC Press
Release Date : 2019-08-30
Toxicology Of The Kidney written by Joan B Tarloff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-30 with categories.
The kidney plays a vital role in certain endocrine functions. Abnormalities caused by toxic chemicals or other interventions can have profound effects on these functions and consequently, on total functions. Toxicology of the Kidney, Third Edition is updated to reflect the latest research in this field and focuses on the correlation between anatomy, biochemistry, and physiology of the kidney. The text explains how these factors are related to concepts of clinical nephrotoxicity and renal failure in humans, and how animal models can be used to understand the mechanisms of human renal disease. In addition to updating many of the key elements of previous editions, such as in vitro models for studying renal function and toxicity and classic nephrotoxicants, it also incorporates cutting edge information on newly emerging areas of renal research. These include mechanisms of cell injury, signaling pathways, biomarkers of renal disease and the interface between basic renal science and clinical outcomes. This book includes current reviews of unpublished and recently published information which allows it to serve as a concise compendium of many key topics that will continue to play a central role in our understanding and treatment of nephrotoxicity for decades to come.
Toxicology Of The Kidney Third Edition
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Author : Joan B. Tarloff
language : en
Publisher: CRC Press
Release Date : 2004-12-28
Toxicology Of The Kidney Third Edition written by Joan B. Tarloff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-28 with Medical categories.
The kidney plays a vital role in certain endocrine functions. Abnormalities caused by toxic chemicals or other interventions can have profound effects on these functions and consequently, on total functions. Toxicology of the Kidney, Third Edition is updated to reflect the latest research in this field and focuses on the correlation between anatomy, biochemistry, and physiology of the kidney. The text explains how these factors are related to concepts of clinical nephrotoxicity and renal failure in humans, and how animal models can be used to understand the mechanisms of human renal disease. In addition to updating many of the key elements of previous editions, such as in vitro models for studying renal function and toxicity and classic nephrotoxicants, it also incorporates cutting edge information on newly emerging areas of renal research. These include mechanisms of cell injury, signaling pathways, biomarkers of renal disease and the interface between basic renal science and clinical outcomes. This book includes current reviews of unpublished and recently published information which allows it to serve as a concise compendium of many key topics that will continue to play a central role in our understanding and treatment of nephrotoxicity for decades to come.
Clinical Nephrotoxins
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Author : Marc E. de Broe
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-15
Clinical Nephrotoxins written by Marc E. de Broe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-15 with Medical categories.
Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals, Third Edition is a comprehensive text on all aspects of adverse effects by drugs, chemical substances and radiation on the kidneys. The importance of the toxicity of drugs and other substances for the kidneys is increasingly recognized. The book consists of themes such as clinical relevance, renal handling and cellular mechanisms of nephrotoxicity, as well as animal and cell culture models. In addition, the volume highlights specific types of drugs, such as anti-infectious agents and anti-inflammatory, cardiovascular and anti-cancer drugs. The last section deals with prevention and focuses on urinary biomarkers, pharmacological aspects and drug dosage in renal failure. In this third and completely revised edition, several new topics were added and additional figures and tables will be included. The book is of interest for the nephrologist, internist, general practitioner, toxicologist, pharmacologist, anesthesiologist, epidemiologist, public health official, pharmaceutical industry, and national drug safety committees, among others.
Nephrology And Public Health Worldwide
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Author : G.B. Silva Junior
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2021-11-02
Nephrology And Public Health Worldwide written by G.B. Silva Junior and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-02 with Medical categories.
Nephrology is one of the fastest growing specialties in medicine. Nevertheless, kidney disease is one of the most serious unmet health needs in many countries. To provide healthcare access with the desirable equity worldwide, the nephrology community needs to discuss this public health issue and take part in decisions for elaboration of public health policies with more justice and equity. This book brings together key current public health problems that affect kidney function and illuminates them in contributions by an international group of nephrologists and general practitioners. The chapters review current knowledge and provide guidelines to manage these conditions and decrease the disease burden. At the end, developments in the digital era and their application to kidney disease treatment are synthesized, and a broader outlook on the future of nephrology is given. Ultimately, the publication aims to gather nephrology and public health expertise from researchers from all over the world, providing a broad vision of issues that must be discussed and overcome to guarantee a better treatment for patients with kidney diseases in the world today.
Comprehensive Toxicology Volume 7
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Author : R.S. Goldstein
language : en
Publisher: Pergamon
Release Date : 1999-08-18
Comprehensive Toxicology Volume 7 written by R.S. Goldstein and has been published by Pergamon this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-08-18 with Medical categories.
Current concepts on mechanisms mediating chemically induced nephrotoxicity are rapidly evolving. This volume is focused on capturing this rapidly growing field by providing a comprehensive, state-of-the-art review of renal pathophysiology and toxicology, written by internationally recognized experts in the field. The first section of this volume is designed to provide the reader with the needed background information; including an overview of clinical nephrotoxicity, the anatomy and physiology of the kidney and urinary bladder, renal transport mechanisms, xenobiotic metabolism, and in vivo and in vitro methods used to assess renal toxicity. Our current state of knowledge on the pathophysiology and biochemistry of acute renal failure, renal and urinary bladder carcinogenesis, and immune-mediated renal injury are covered in detail. The role of vasoactive substances, cell adhesion molecules, oxidative stress/antioxidants and membrane changes in composition/fluidity in mediating nephrotoxic, and ischemic renal injury are reviewed and provide the reader with the conceptual framework for understanding key mechanisms of renal injury. In addition, the role of gene expression and growth factors in renal injury and repair are discussed. The response of each of the major segments of the nephron to a toxic insult is discussed in detail; with chapters devoted to mechanisms mediating injury to the glomerulus, proximal tubule, collecting duct and papilla and the tubulointerstitium. Various nephrotoxicants are discussed in detail with an emphasis on pathophysiologic and morphologic effects and mechanisms of toxicity. Wherever possible, the relevance of experimental findings to human exposure is covered.
Toxicology Of The Kidney
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Author : Jerry B. Hook
language : en
Publisher: CRC Press
Release Date : 1993-06-30
Toxicology Of The Kidney written by Jerry B. Hook and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-06-30 with Medical categories.
This second edition provides a synthesis of recent research on the mechanisms of chemically-induced kidney injury. The text includes a review of current concepts of clinical nephrotoxicity and renal failure, and mechanisms of specific classes of nephrotoxic drugs and environmental chemicals.
Renal Failure
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Author : Colin Andrew Hutchison
language : en
Publisher: Nova Science Publishers
Release Date : 2013
Renal Failure written by Colin Andrew Hutchison and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Acute renal failure categories.
Kidney failure represents a major health economic burden for all people and all nations. Despite the immense number of factors which can cause the initial injury to the kidneys, common response pathways are triggered which, unless broken, will ultimately lead to irreversible fibrosis within the kidneys. Unfortunately, early injuries to the kidneys can frequently be asymptomatic and chronic kidney disease has often developed before the patient has become aware there is a problem. Once established, chronic kidney disease is associated with a high morbidity and mortality for those affected. There has been a large amount of work in recent years focused on the early diagnosis and management of kidney disease to prevent its progression. The purpose of this book is to review the mechanisms which underlie both acute and chronic kidney injury, discuss their diagnosis, complications and management. The first section of this book covers the causes and complications of chronic kidney disease. Initially we review the mechanisms which underlie the progressive fibrosis by which chronic kidney disease progresses. There are then detailed discussions of the cardiovascular complications of chronic kidney disease. The second section of the book focuses on established end stage renal disease. Reviewing access to renal replacement therapies across ethnicities, the role of home therapies and how their use can be increased and finally we discuss the preparation and maintenance of access for dialysis. The third and final section of the book provides an update for the clinician into the diagnosis and management of acute kidney injury. Specifically the diagnosis and management of renal impairment in patients with plasma cell dyscrasias is reviewed and the prevention of acute kidney injury in the critically ill patient is discussed in detail.
Renal Pathophysiology
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Author : Helmut G. Rennke
language : en
Publisher:
Release Date : 2014
Renal Pathophysiology written by Helmut G. Rennke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Medical categories.
This text offers medical students a case-based approach to learning the mechanisms of renal disease. Each chapter covers a disease, beginning with a patient case and followed by a discussion of the pathophysiology of the disease. Issues of differential diagnosis and therapy are linked to pathophysiologic mechanisms. Short questions interspersed throughout the text require students to apply their knowledge. Detailed answers to the questions are included. New to this edition: Full-color artwork and design New color photomicrographs of clinical conditions Additional end-of-chapter summaries Up-to-date information based on new medical findings
Uremic Toxins
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Author : Severin Ringoir
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Uremic Toxins written by Severin Ringoir and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The present book contains the Proceedings of a two day Symposium on Uremic Toxins organized at the University of Ghent in Belgium. A series of guest lectures, free communications and posters have been presented. An international audience of 163 scientists from 16 nationalities listened to and discussed extensively a spectrum of topics brought forward by colleagues and researchers who worked for many years in the field of Uremic Toxins. There is a striking contrast between all the new dialysis strategies available in the work to "clean" the uremic patients and the almost non-progression of our knowledge on uremic toxins in the past decade. In this sense the symposium was felt by all participants as a new start for the research in the biochemical field of the definition of uremia. If the present volume would stimulate new work in this field in order to define uremia, or identify the uremic toxins, the purpose of the organizers would be maximally fulfilled.