Mechanisms Of Ion Channels Voltage Dependency
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Mechanisms Of Ion Channels Voltage Dependency
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Author : Gildas Loussouarn
language : en
Publisher: Frontiers E-books
Release Date :
Mechanisms Of Ion Channels Voltage Dependency written by Gildas Loussouarn and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Voltage-gated ion channels are transmembrane proteins in which at least one gate is controlled by the transmembrane potential. They are frequently very selectively permeable to sodium (Nav channels), potassium (Kv channels) or calcium (Cav channels) ions. Depending on the channels, opening of the activation gate is triggered by membrane depolarization (Kv, Nav and Cav channels) or hyperpolarization (HCN channels for instance). In addition, in many voltage-gated channels, a so-called inactivation gate is also present. Compared to the activation gate, the latter is oppositely coupled to the potential: In Kv, Nav and Cav channels, upon membrane depolarization, the inactivation gate closes whereas the activation gate opens. Depending on the cell types in which they are expressed and their physiological role, various voltage-dependent channels can be characterized by their conductance, ion selectivity, pharmacology and voltage-sensitivity. These properties are mainly dictated by the amino-acids sequence and structure of the pore forming subunit(s), presence of accessory subunit(s), membrane composition, intra- and extracellular ions concentration. Noteworthy, despite a profound variety of these ion channels characteristics, it seems that most of them obey to the same global, four-fold structure now obtained by several X-ray crystallography experiments. Given the wealth of electrophysiological, biochemical, optical, and structural data regarding ion channels voltage-dependency, we decided to put together in this e-book, up to date reviews describing the molecular details of these complex voltage-gated channels.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Handbook Of Ion Channels
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Author : Jie Zheng
language : en
Publisher: CRC Press
Release Date : 2015-02-25
Handbook Of Ion Channels written by Jie Zheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-25 with Medical categories.
The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce
Molecular Mechanisms Of Voltage Gating In Ion Channels
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Author : Gildas Loussouarn
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-03
Molecular Mechanisms Of Voltage Gating In Ion Channels written by Gildas Loussouarn and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-03 with Science categories.
Basic Neurochemistry
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Author : R. Wayne Albers
language : en
Publisher: Elsevier
Release Date : 2005-11-11
Basic Neurochemistry written by R. Wayne Albers and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-11 with Science categories.
Basic Neurochemistry: Molecular, Cellular and Medical Aspects, a comprehensive text on neurochemistry, is now updated and revised in its Seventh Edition. This well-established text has been recognized worldwide as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for graduate and postgraduate students and instructors in the neurosciences. It is an excellent source of information on basic biochemical processes in brain function and disease for qualifying examinations and continuing medical education. - Completely updated with 60% new authors and material, and entirely new chapters - Over 400 fully revised figures in splendid color
Regulatory Mechanisms Of Ca2 Activated Ion Channels And Their Impacts On Physiological Pathophysiological Functions
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Author : Yoshiaki Suzuki
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-27
Regulatory Mechanisms Of Ca2 Activated Ion Channels And Their Impacts On Physiological Pathophysiological Functions written by Yoshiaki Suzuki and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-27 with Science categories.
Biomedical Index To Phs Supported Research
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Author :
language : en
Publisher:
Release Date : 1993
Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medicine categories.
Neural Mechanisms Of Anesthesia
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Author : Joseph E. Antognini
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-08-22
Neural Mechanisms Of Anesthesia written by Joseph E. Antognini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-08-22 with Medical categories.
Leading investigators critically evaluate the latest information on how anesthetics work at the molecular, cellular, organ, and whole animal level. These distinguished experts review anesthetic effects on memory, consciousness, and movement and spell out in detail both the anatomic structures and physiological processes that are their likely targets, as well as the cellular and molecular mechanisms by which they operate. Comprehensive and authoritative, Neural Mechanisms of Anesthesia draws together and critically reviews all the recent research on anesthetic mechanisms, highlighting the precise routes along which these substances operate, and how this deeper understanding will lead to the design of effective drugs free ofundesirable side effects.
Ion Channels In Health And Sickness
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Author : Fatima Shad Kaneez
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-10-10
Ion Channels In Health And Sickness written by Fatima Shad Kaneez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-10 with Science categories.
Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Ion Channels And Their Inhibitors
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Author : Satya Prakash Gupta
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-21
Ion Channels And Their Inhibitors written by Satya Prakash Gupta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-21 with Science categories.
Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.