Mechanisms Of Toxicity

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Applications Of Toxicogenomic Technologies To Predictive Toxicology And Risk Assessment

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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2007-11-19

Applications Of Toxicogenomic Technologies To Predictive Toxicology And Risk Assessment written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-19 with Science categories.

The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Engineered Nanoparticles

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Author : Ashok K. Singh
language : en
Publisher: Academic Press
Release Date : 2015-11-24

Engineered Nanoparticles written by Ashok K. Singh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-24 with Medical categories.

Engineered Nanoparticles: Structure, Properties and Mechanisms of Toxicity is an indispensable introduction to engineered nanomaterials (ENM) and their potential adverse effects on human health and the environment. Although research in the area of pharmacology and toxicology of ENM is rapidly advancing, a possible correlation between their physicochemical properties and biomedical properties or toxicity is not yet fully understood. This understanding is essential to develop strategies for the safe applications and handling of ENM. The book comprehensively defines the current understanding of ENM toxicity, first describing these materials and their physicochemical properties, and then discussing the toxicological theory and methodology before finally demonstrating the potential impact of ENM on the environment and human health. It represents an essential reference for students and investigators in toxicology, pharmacology, chemistry, material sciences, medicine, and those in related disciplines who require an introduction to ENM and their potential toxicological effects. - Provides state-of-the-art physicochemical descriptions and methodologies for the characterization of engineered nanomaterials (ENM) - Describes the potential toxicological effects of ENM and the nanotoxicological mechanisms of action - Presents how to apply theory to practice in a public health and risk assessment setting

Mechanisms Of Toxicity

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Author : W. Norman Aldridge
language : en
Publisher:
Release Date : 1971

Mechanisms Of Toxicity written by W. Norman Aldridge and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1971 with categories.

Arsenic

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Author : J. Christopher States
language : en
Publisher: John Wiley & Sons
Release Date : 2015-10-26

Arsenic written by J. Christopher States and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-26 with Science categories.

This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives. • Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world • Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models • Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity • Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up-to-date, novel modeling techniques for scientists • Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure

Poisoning In The Modern World

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Author : Ozgur Karcioglu
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-06-19

Poisoning In The Modern World written by Ozgur Karcioglu and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-19 with Medical categories.

Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: "All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy." This is often condensed to: "The dose makes the poison." So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.

Mechanistic Toxicology

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Author : Urs A. Boelsterli
language : en
Publisher: CRC Press
Release Date : 2007-03-23

Mechanistic Toxicology written by Urs A. Boelsterli and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-23 with Medical categories.

A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology. Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity. New in the Second Edition Updated chapters Types of toxic responses Disruption of signal transduction by xenobiotics Disruption of mitochondrial function Novel mechanisms derived from systems toxicology

Toxicity Testing For Assessment Of Environmental Agents

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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2006-04-07

Toxicity Testing For Assessment Of Environmental Agents written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-07 with Nature categories.

Toxicity testing in laboratory animals provides much of the information used by the Environmental Protection Agency (EPA) to assess the hazards and risks associated with exposure to environmental agents that might harm public health or the environment. The data are used to establish maximum acceptable concentrations of environmental agents in drinking water, set permissible limits of exposure of workers, define labeling requirements, establish tolerances for pesticides residues on food, and set other kinds of limits on the basis of risk assessment. Because the number of regulations that require toxicity testing is growing, EPA called for a comprehensive review of established and emerging toxicity-testing methods and strategies. This interim report reviews current toxicity-testing methods and strategies and near-term improvements in toxicity-testing approaches proposed by EPA and others. It identifies several recurring themes and questions in the various reports reviewed. The final report will present a long-range vision and strategic plan to advance the practices of toxicity testing and human health assessment of environmental contaminants.

Toxicology Of Cyanides And Cyanogens

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Author : Alan H. Hall
language : en
Publisher: John Wiley & Sons
Release Date : 2015-10-13

Toxicology Of Cyanides And Cyanogens written by Alan H. Hall and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-13 with Medical categories.

The basic and applied toxicology of cyanides and cyanogens has widespread commercial, occupational, environmental, clinical, forensic, military, and public health implications. This book provides a detailed and updated reference describing the properties, uses, general and human toxicology, clinical recognition, diagnosis and medical management, and countermeasures is therefore required in academic, medical, occupational, environmental, medico-legal, regulatory, emergency response, and military arenas. Edited by a world-renowned team of experts from academia, defense and industry, this book will be an invaluable reference for professionals, researchers and students in cyanide and cyanogens.

Stress Responses In Plants

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Author : Bhumi Nath Tripathi
language : en
Publisher: Springer
Release Date : 2015-05-27

Stress Responses In Plants written by Bhumi Nath Tripathi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-27 with Science categories.

This collection discusses the variety of specific molecular reactions by means of which plants respond to physiological and toxic stress conditions. It focuses on the characterization of the molecular mechanisms that underlie the induction of toxicity and the triggered responses and resistances. The nine chapters, all written by prominent researchers, examine heavy metal toxicity, aluminum toxicity, arsenic toxicity, salt toxicity, drought stress, light stress, temperature stress, flood stress and UV-B stress. In addition, information on the fundamentals of stress responses and resistance mechanisms is provided. The book addresses researchers and students working in the fields of plant physiology and biochemistry.​

Biochemical Mechanisms Of Paraquat Toxicity

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Author : Anne Pomeroy Autor
language : en
Publisher:
Release Date : 1977

Biochemical Mechanisms Of Paraquat Toxicity written by Anne Pomeroy Autor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Medical categories.

Biochemical Mechanisms of Paraquat Toxicity ...