Medical Biochemical And Chemical Aspects Of Free Radicals
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Medical Biochemical And Chemical Aspects Of Free Radicals
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Author : Osamu Hayaishi
language : en
Publisher: Elsevier Publishing Company
Release Date : 1989
Medical Biochemical And Chemical Aspects Of Free Radicals written by Osamu Hayaishi and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medical categories.
There is now increasing evidence that free radicals play an important role in biological systems and that they are closely connected to a variety of pathological events, including cancer and aging. It is also known that biological systems are protected against free radical attack by an array of defence systems, e.g. vitamins C and E and superoxide dismutase. However, details of the generation, function and scavenging of free radicals or repair are not well understood and are often controversial. These two volumes contain almost 320 papers from the international community of experts in this field. Taken as a whole, the work provides the present state of the art of the role of free radicals from medical, biochemical and chemical viewpoints. The volumes will thus be of interest to chemists, biochemists, pharmacologists, medical scientists and clinicians, and to those working in the pharmaceutical and chemical industries.
Free Radicals In Biology And Medicine
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Author : Barry Halliwell
language : en
Publisher: OUP Oxford
Release Date : 2015-08-21
Free Radicals In Biology And Medicine written by Barry Halliwell and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-21 with Science categories.
Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
Free Radicals In Chemistry Biology And Medicine
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Author : Toshikazu Yoshikawa
language : en
Publisher:
Release Date : 2000
Free Radicals In Chemistry Biology And Medicine written by Toshikazu Yoshikawa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Antioxidants categories.
Free Radical Reactions In Medicine
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Author : Janos Feher
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Free Radical Reactions In Medicine written by Janos Feher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book aims to provide a concise review of the medical aspects of free radical reactions. Until now, there have been extensive reviews of the subject in a physiological, pathophysiological and biochemical context. Here, however, the authors concentrate on the biology of free radical reactions as relevant to medical practice, emphasizing that the topic is not just a branch of basic science. Consequently, a short introduction on chemical and biological aspects is followed by a detailed discussion of the role played by free radical reactions in the pathogenesis and development of several human diseases and in therapeutic possibilities. The summary of data from the literature is supplemented by the authors' own experimental results. The presentation will help medical researchers to notice so far unknown connections among several diseases and to make them aware of the existance of the so-called "free radical diseases".
Free Radicals In Biology And Environment
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Author : F. Minisci
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Free Radicals In Biology And Environment written by F. Minisci and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.
Our understanding of the quantitative aspects of free radical chemistry and the involvement of radicals in such areas as biology, medicine, the environment, etc., has developed spectacularly over recent years, yet the various topics are commonly discussed separately, in specific meetings and specialised publications. Free Radicals in Biology and Environment draws together two important areas of free radical chemistry, using as a bridge the fundamental physical chemistry of free radicals (spectroscopic detection of free radicals, evaluation of absolute rate constants, elucidation of mechanisms of free radical reactions and catalysis, photochemical and radiation processes, etc.). The most relevant topics covered are the EPR detection of radicals in biochemical systems and in pollutant formation and degradation, oxidation processes in biology and in the troposphere, radiation and induced damage, and atmospheric pollutants arising from incomplete combustion. Also covered are the chemistry and biochemistry of nitric oxide and peroxynitrite, the chemistry and biochemistry of DNA radicals, the role of radicals in myeloperoxidase, lignineperoxidase, radicals and cardiovascular injury, radiation and the fragmentation of cells and tissues.
Free Radicals And Iron
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Author : Martyn C. R. Symons
language : en
Publisher:
Release Date : 1998
Free Radicals And Iron written by Martyn C. R. Symons and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Active oxygen in the body categories.
This concise monograph describes a variety of important reactions of iron in biological free-radical reactions. It presents both a chemical and a biochemical perspective of the topic, but at the same time unifies ideas where possible. Iron plays a key role in biological life processes, as acatalayst enabling us to use oxygen to generate the heat and chemical energy that drives life. When iron is not properly controlled within the body it can cause damage by making free radicals. The authors present a chemical and biomedical perspective of how reactions of iron complexes and freeradicals may contribute to human health and disease, especially in reactions of oxygen and hydrogen peroxide.
Oxygen Radicals In Biology And Medicine
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Author : Michael Simic
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Oxygen Radicals In Biology And Medicine written by Michael Simic and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.
Free Radicals And Oxidation Phenomena In Biological Systems
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Author : Roberfroid
language : en
Publisher: CRC Press
Release Date : 1994-12-14
Free Radicals And Oxidation Phenomena In Biological Systems written by Roberfroid and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-12-14 with Medical categories.
This work offers an analysis of the biological processes mediated by free radicals, from a toxicological point of view, providing easy access to information in an integrated, coherent presentation. The chemistry and biochemistry of all principal types of radical are explained, and the multiple forms in whch radicals participate in living organisms are investigated.;This work should be of use to biochemists, pharmacologists, pharmaceutical researchers, food scientists and technologists, nutritionists, toxicologists, chemists, biologists and graduate students in these disciplines.
Excited States And Free Radicals In Biology And Medicine
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Author : R. V. Bensasson
language : en
Publisher:
Release Date : 1993
Excited States And Free Radicals In Biology And Medicine written by R. V. Bensasson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Cancer categories.
Excited states and free radicals are involved in the normal physiology of living systems, in pathological processes (including lipid peroxidation, inflammation, Parkinson's disease, cancer, and aging), in the mechanisms of drug action, and in the photochemotherapies such as the PUVA therapy for skin diseases and PDT for cancer. This text introduces the reader to this rapidly expanding field, one that lies at the borderlines of physics, chemistry, biology, pharmacology, and medicine. The authors explore in particular how time-resolved spectroscopic methods have found solutions at the molecular level to biological and medical problems. Topics include the nature of excited states and free radicals and the techniques for their study, activated oxygen species, DNA, proteins, carotenoids and photosynthetic reaction centers, photodermatology and melanogenesis, and aspects of cancer related to radio-, chemo-, and photodynamic therapy. Researchers and graduate students in photochemistry, photobiology, photomedicine, radiation chemistry and biology, and cancer therapies will find this book to be of very significant interest.
Free Radicals In Medicine
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Author : Radu Olinescu
language : en
Publisher: Nova Publishers
Release Date : 2002
Free Radicals In Medicine written by Radu Olinescu and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Antioxidants categories.
The role of reactive oxygen species and other free radicals in normal and disease processes has become a major area of interest in the medical scientific community. In the past 30 years, this area of study has advanced from outright rejection, to general acceptance, to intense study. While there is still some dispute as to the exact role of these highly reactive molecules in pathology, it is clear that they are present in and influence many biological processes. This book provides an overview of the possible biological effects of reactive oxygen species and other free radicals with an emphasis on pathology. The various types of free radicals that may affect the body are discussed along with the potential sources of free radicals, both internal and external to the body. The extensive defenses the body raises against the effects of these molecules in the form of enzymatic and non-enzymatic antioxidants is reviewed. A variety of conditions in which free radicals have been proposed to play a role are discussed. These include the physiological effects of oxygen stress in aging, exercise, and pregnancy. Pathologic conditions discussed include cancer, liver cirrhosis, respiratory problems, and others.