Membrane Active Peptides
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Membrane Active Peptides
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Author : Miguel A. R. B. Castanho
language : en
Publisher: Internat'l University Line
Release Date : 2010
Membrane Active Peptides written by Miguel A. R. B. Castanho and has been published by Internat'l University Line this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
Advances In Biological Solid State Nmr
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Author : Frances Separovic
language : en
Publisher: Royal Society of Chemistry
Release Date : 2014
Advances In Biological Solid State Nmr written by Frances Separovic and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Science categories.
Advances in Biological NMR brings the reader up to date with chapters from international leaders of this growing field, covering the most recent developments in the methodology and applications of solid state NMR to studies of membrane interactions and molecular motions
Design And Optimization Of Membrane Active Peptides And Lipid Vesicles For Triggered Release
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Author : Johanna Utterström
language : en
Publisher:
Release Date : 2024
Design And Optimization Of Membrane Active Peptides And Lipid Vesicles For Triggered Release written by Johanna Utterström and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with categories.
Handbook Of Biologically Active Peptides
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Author : Abba Kastin
language : en
Publisher: Academic Press
Release Date : 2013-01-26
Handbook Of Biologically Active Peptides written by Abba Kastin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-26 with Science categories.
Handbook of Biologically Active Peptides, Second Edition, is the definitive, indispensable reference for peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a source for workers in the field and enable researchers working in a specific area to examine related areas outside their expertise. Peptides play a crucial role in many physiological processes, including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The second edition of Handbook of Biologically Active Peptides presents this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. Presents all aspects of biologically active peptides in one resource Features more than 20 sections spanning plant, bacterial, fungal, venom, and invertebrate peptides to general peptides Includes immunological, inflammatory, cancer, vaccine, and neurotrophic peptides Discusses peptide precursors, mRNA distribution, processing, and receptors, not just pathophysiological implications
Cell Penetrating Peptides
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Author : Ulo Langel
language : en
Publisher: CRC Press
Release Date : 2002-05-29
Cell Penetrating Peptides written by Ulo Langel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-05-29 with Medical categories.
One of the major problems with drug delivery is the inability of large hydrophilic compounds to pass through the lipid membrane of the cell, thus making drugs such as polypeptides and oligonucleotides of limited therapeutic value. Until recently, the transport of such molecules into the cytoplasmic and nuclear compartments of living cells seemed a
Biologically Active Peptides
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Author : David B. Weiner
language : en
Publisher: CRC Press
Release Date : 1993-11-04
Biologically Active Peptides written by David B. Weiner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-11-04 with Medical categories.
Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.
Biologically Active Peptides
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Author : David B. Weiner
language : en
Publisher: CRC Press
Release Date : 2023-07-28
Biologically Active Peptides written by David B. Weiner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-28 with Medical categories.
Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.
Peptide Liposome Model Systems For Triggered Release
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Author : Camilla Skyttner
language : en
Publisher: Linköping University Electronic Press
Release Date : 2018-09-12
Peptide Liposome Model Systems For Triggered Release written by Camilla Skyttner and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-12 with categories.
Liposomes are widely used in drug delivery to improve drug efficacy and to reduce side effects. For liposome-encapsulated drugs to become bioavailable and provide a therapeutic effect they must be released, which typically is a slow process that primarily relies on passive diffusion, liposome rupture or endocytotic uptake. Achieving drug concentrations within the therapeutic window can thus be challenging, resulting in poor efficacy and higher risks drug resistance. Finding means to modulate lipid membrane integrity and to trigger rapid and efficient release of liposomal cargo is thus critical to improve current and future liposomal drug delivery systems. The possibilities to tailor lipid composition and surface functionalization is vital for drug delivery applications but also make liposomes attractive model systems for studies of membrane active biomolecules. The overall aim of this thesis work has been to develop new strategies for triggering and controlling changes in lipid membrane integrity and to study the interactions of membrane active peptides with model lipid membranes using both de novo designed and biologically derived synthetic amphipathic cationic peptides. Two different sets of designed peptides have been explored that can fold and heterodimerize into a coiled coil and helix-loop-helix fourhelix bundle, respectively. Conjugation of the cationic lysine rich peptides to liposomes triggered a rapid and concentration dependent release. The additions of their corresponding glutamic acid-rich complementary peptides inhibited the release of liposomal cargo. Possibilities to reduce the inhibitory effect by both proteolytic digestion of the inhibitory peptide and by means of heterodimer exchange have been investigated. Moreover, the effects of peptide size and composition and ability to fold have been studied in order to elucidate the factors that influence the membrane permeabilizing effects of the peptides. In addition, the membrane activity of a the two-peptide bacteriocin PLNC8? and PLNC8? has been explored using liposomes as a model system. PLNC8?? are expressed by Lactobacillus plantarum and were shown to display pronounced membrane-partition folding coupling, leading to rapid release of liposome encapsulated carboxyfluorescein. PLNC8?? also kill and suppressed growth of the gram-negative bacteria Porphyromonas gingivalis by efficiently damaging the bacterial membrane. Although membrane active peptides are highly efficient in perturbing lipid membrane integrity, possibilities to trigger release using external stimuli are also of large interest for therapeutic applications. Light-induced heating of liposome encapsulated gold nanoparticles (AuNPs) has been shown by others as a potential strategy to trigger drug release. To facilitate fabrication of thermoplasmonic liposome systems we developed a simple method for synthesis of small AuNPs inside liposomes, using the liposomes as nanoscale reaction vessels. The work presented in this thesis provides new knowledge and techniques for future development of liposome-based drug delivery systems, peptide-based therapeutics and increase our understanding of peptide-lipid interactions.
Membrane Peptide Interactions
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Author : Nuno C. Santos
language : en
Publisher:
Release Date : 2020
Membrane Peptide Interactions written by Nuno C. Santos and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
This book summarizes the importance of peptide-membrane interactions, mostly aiming at developing new therapeutic approaches. The experimental and computational methodologies used to investigate such interactions reveal the evolution of existing biophysical methodologies, shedding some light on potential applications of peptides, as well as on the improvement of their design. Understanding the determinants for peptide-membrane interactions may also improve the knowledge of membrane functions such as the membrane transport, fusion, and signaling processes, contributing to the development of new agents for highly relevant applications ranging from disease treatment to food technology.
Micropipette Manipulation Technique For The Monitoring Of Membrane Fusion And Lysis Induced By Membrane Active Peptides And Proteins
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Author : Sharon Ann Soltesz
language : en
Publisher:
Release Date : 1994
Micropipette Manipulation Technique For The Monitoring Of Membrane Fusion And Lysis Induced By Membrane Active Peptides And Proteins written by Sharon Ann Soltesz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.