Meta Analysis In Clinical Research Principles And Procedures

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Meta Analysis In Clinical Research Principles And Procedures

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Author : Anoop Kumar
language : en
Publisher: Springer Nature
Release Date : 2023-08-22

Meta Analysis In Clinical Research Principles And Procedures written by Anoop Kumar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-22 with Medical categories.

This book provides conceptual information on the various processes involved in meta-analysis. It examines the importance of meta-analysis for the analyses of clinical data to draw a valid conclusion using suitable software. The initial sections of the book introduce meta-analysis, how to perform a systematic literature review (SLR), quality assessment of studies, extraction, and analysis of data. The subsequent section of the book contains information on advanced topics including, meta-regression, network meta-analysis, issues, mistakes, and future perspectives. In summary, the book provides a statistical method for combining the results of different studies on the same topic and resolving conflicts among studies. This book is written with the intent to allow a wide range of readers including students, researchers, and health care professionals, including physicians, nurses, pharmacists, and paramedical, and is also helpful for a beginner who would like to do a meta-analysis.

Sharing Clinical Trial Data

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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2015-04-20

Sharing Clinical Trial Data written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-20 with Medical categories.

Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.

Cochrane Handbook For Systematic Reviews Of Interventions

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Author : Julian P. T. Higgins
language : en
Publisher: Wiley
Release Date : 2008-11-24

Cochrane Handbook For Systematic Reviews Of Interventions written by Julian P. T. Higgins and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-24 with Medical categories.

Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.

Systematic Reviews In Health Care

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Author : Matthias Egger
language : en
Publisher: John Wiley & Sons
Release Date : 2013-07-01

Systematic Reviews In Health Care written by Matthias Egger and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-01 with Medical categories.

The second edition of this best-selling book has been thoroughly revised and expanded to reflect the significant changes and advances made in systematic reviewing. New features include discussion on the rationale, meta-analyses of prognostic and diagnostic studies and software, and the use of systematic reviews in practice.

Finding What Works In Health Care

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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-06-20

Finding What Works In Health Care written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-20 with Medical categories.

Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.

Meta Regression Analysis In Economics And Business

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Author : T. D. Stanley
language : en
Publisher: Routledge
Release Date : 2012

Meta Regression Analysis In Economics And Business written by T. D. Stanley and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Business & Economics categories.

Meta-Regression Analysis in Economics and Business is the first text devoted to the meta-regression analysis (MRA) of economics and business research.

Principles Of Research Methodology

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Author : Phyllis G. Supino
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-22

Principles Of Research Methodology written by Phyllis G. Supino and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-22 with Medical categories.

Principles of Research Methodology: A Guide for Clinical Investigators is the definitive, comprehensive guide to understanding and performing clinical research. Designed for medical students, physicians, basic scientists involved in translational research, and other health professionals, this indispensable reference also addresses the unique challenges and demands of clinical research and offers clear guidance in becoming a more successful member of a medical research team and critical reader of the medical research literature. The book covers the entire research process, beginning with the conception of the research problem to publication of findings. Principles of Research Methodology: A Guide for Clinical Investigators comprehensively and concisely presents concepts in a manner that is relevant and engaging to read. The text combines theory and practical application to familiarize the reader with the logic of research design and hypothesis construction, the importance of research planning, the ethical basis of human subjects research, the basics of writing a clinical research protocol and scientific paper, the logic and techniques of data generation and management, and the fundamentals and implications of various sampling techniques and alternative statistical methodologies. Organized in thirteen easy to read chapters, the text emphasizes the importance of clearly-defined research questions and well-constructed hypothesis (reinforced throughout the various chapters) for informing methods and in guiding data interpretation. Written by prominent medical scientists and methodologists who have extensive personal experience in biomedical investigation and in teaching key aspects of research methodology to medical students, physicians and other health professionals, the authors expertly integrate theory with examples and employ language that is clear and useful for a general medical audience. A major contribution to the methodology literature, Principles of Research Methodology: A Guide for Clinical Investigators is an authoritative resource for all individuals who perform research, plan to perform it, or wish to understand it better.

Research Synthesis And Meta Analysis

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Author : Harris Cooper
language : en
Publisher: SAGE Publications
Release Date : 2015-12-24

Research Synthesis And Meta Analysis written by Harris Cooper and has been published by SAGE Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-24 with Social Science categories.

The Fifth Edition of Harris Cooper′s bestselling text offers practical advice on how to conduct a synthesis of research in the social, behavioral, and health sciences. The book is written in plain language with four running examples drawn from psychology, education, and health science. With ample coverage of literature searching and the technical aspects of meta-analysis, this one-of-a-kind book applies the basic principles of sound data gathering to the task of producing a comprehensive assessment of existing research.

Textbook Of Pharmacoepidemiology

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Author : Brian L. Strom
language : en
Publisher: John Wiley & Sons
Release Date : 2013-05-13

Textbook Of Pharmacoepidemiology written by Brian L. Strom and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-13 with Medical categories.

The Textbook of Pharmacoepidemiology provides a streamlined text for evaluating the safety and effectiveness of medicines. It includes a brief introduction to pharmacoepidemiology as well as sections on data sources, methodology and applications. Each chapter includes key points, case studies and essential references. One-step resource to gain understanding of the subject of pharmacoepidemiology at an affordable price Gives a perspective on the subject from academia, pharmaceutical industry and regulatory agencies Designed for students with basic knowledge of epidemiology and public health Includes many case studies to illustrate pharmacoepidemiology in real clinical setting

Meta Analysis Of Controlled Clinical Trials

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Author : Anne Whitehead
language : en
Publisher: John Wiley & Sons
Release Date : 2002-08-16

Meta Analysis Of Controlled Clinical Trials written by Anne Whitehead and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-08-16 with Mathematics categories.

Over the last twenty years there has been a dramatic upsurge in the application of meta-analysis to medical research. This has mainly been due to greater emphasis on evidence-based medicine and the need for reliable summaries of the vast and expanding volume of clinical research. At the same time there have been great strides in the development and refinement of the associated statistical methodology. This book describes the planning, conduct and reporting of a meta-analysis as applied to a series of randomized controlled clinical trials. The various approaches are presented within a general unified framework. Meta-analysis techniques are described in detail, from their theoretical development through to practical implementation. Each topic discussed is supported by detailed worked examples. A comparison of fixed and random effects approaches is included, as well as a discussion of Bayesian methods and cumulative meta-analysis. Fully documented programs using standard statistical procedures in SAS are available on the Web. Ideally suited for practising statisticians and statistically-minded medical professionals, the book will also be of use to graduate students of medical statistics. The book is a self-contained and comprehensive account of the subject and an essential purchase for anyone involved in clinical trials.