Metabolic Modulation Of Cellular Function
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Metabolic Modulation Of Cellular Function
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Author :
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-26
Metabolic Modulation Of Cellular Function written by and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-26 with Science categories.
Metabolic pathways and their metabolites are gaining recognition as both sensitive biomarkers for pathological conditions and key modulators of cell fate. In the past, metabolic changes were considered a consequence of gene expression, metabolite control, or environmental changes such as starvation. However, extensive research in the last decade has demonstrated that metabolic changes respond to and influence cellular signaling. This crosstalk between metabolism and cellular signaling is mainly enabled by novel metabolite-mediated modulation of enzymatic activity of rate-limiting steps and post-translational and epigenetic modifications, for which metabolites serve as substrates.
Modulation By Covalent Modification
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Author : Shmuel Shaltiel
language : en
Publisher: Elsevier
Release Date : 2014-06-28
Modulation By Covalent Modification written by Shmuel Shaltiel and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-28 with Science categories.
Current Topics in Cellular Regulation: Volume 27, Modulation by Covalent Modification is a compendium of papers dealing with the coordination, function, or control of cellular metabolism, particularly on modulation by covalent modification. One paper reviews the cyclic cascade model in metabolic regulation that shows the model's applicability to all covalent interconvertible enzyme systems, such as those modified by phosphorylation, ADP-ribosylation, carboxymethylation, acetylation, and sulfation. Another paper discusses the hypothesis that smooth muscle contraction is regulated by a calcium-dependent phosphorylation of the myosin molecule. Studies made by Sellers and Pato suggest that a phosphatase isolated from turkey gizzard muscle (known as smooth muscle phosphatase IV) can be related to an in vivo myosin phosphatase as the phosphatase IV binds well to both myosin and thiophosphorylated myosin. Other papers describe in situ regulation studies of Excherichia coli glutamine synthethase, the posttranslational processing of the insulin proreceptor, and selenium in cellular metabolism. The compendium is suitable for biochemists, microbiologists, and academicians whose works involve research in cell biology.
Systems Biology Of Metabolic And Signaling Networks
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Author : Miguel A. Aon
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-22
Systems Biology Of Metabolic And Signaling Networks written by Miguel A. Aon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.
Modulation Of Protein Function
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Author : Daniel E. Atkinson
language : en
Publisher:
Release Date : 1979
Modulation Of Protein Function written by Daniel E. Atkinson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Science categories.
Pancreatic Cell Fatty Acid Metabolism And Modulation Of Function In Response To Glucolipotoxicity
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Author : Christopher D. Green
language : en
Publisher:
Release Date : 2009
Pancreatic Cell Fatty Acid Metabolism And Modulation Of Function In Response To Glucolipotoxicity written by Christopher D. Green and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Fatty acids categories.
Cancer Cell Cycle Modulation By Metabolic Gene Expression And Role Of Photoreceptor Phosphodiesterase 6h In Cancer Cell Growth
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Author : Ceren Yalaz
language : en
Publisher:
Release Date : 2018
Cancer Cell Cycle Modulation By Metabolic Gene Expression And Role Of Photoreceptor Phosphodiesterase 6h In Cancer Cell Growth written by Ceren Yalaz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Progress In Cancer Immunotherapy
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Author : Shuren Zhang
language : en
Publisher: Springer
Release Date : 2016-05-30
Progress In Cancer Immunotherapy written by Shuren Zhang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-30 with Medical categories.
This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. Thanks to rapid advances in molecular biology and immunology, it has become increasingly evident that cancer growth is influenced by host immune responses. With the success of a number of clinical trials, immunotherapy has become a promising treatment modality of cancer. This book covers five major topics, including monoclonal antibodies, biological response modifiers, cancer vaccines, adoptive cellular therapy and oncolytic viruses. It also examines the combination of different immune strategies as well as the combination of immunotherapy with other treatments to increase anti-tumor effects. Through the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors.
Genetic And Epigenetic Modulation Of Cell Functions By Physical Exercise
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Author : Italia Di Liegro
language : en
Publisher:
Release Date : 2020
Genetic And Epigenetic Modulation Of Cell Functions By Physical Exercise written by Italia Di Liegro and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Biology (General) categories.
From an evolutionary perspective, our species has relied upon physical activity for most of its history to survive and has had to escape from predators, to scavenge for food, and to use physique to work or build necessary means for everyday life. Physical activity has been part of our evolution and progress since the very beginning and, consequently, our entire body has been programmed to be active physically. In the last 20 years, scientific research has increasingly shown that our ancient survival principle has beneficial effects not only on the cells and organs involved in physical activities but on the metabolism of the entire organism, influencing the homeostasis and integration of all bodily functions, likely stimulating the production of hormones and other regulatory molecules, with each affecting vital signalling pathways. Most of the web of factors involved in molecular signalling upon exercise are suspected to be centrally controlled by the brain, which has been reported to be deeply modified by physical activity. Such complexity requires a multifaceted approach to shed light on the molecular interactions that occur between physical activity and its outcome at a cellular level.
Autophagy In Tumor And Tumor Microenvironment
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Author : Sujit Kumar Bhutia
language : en
Publisher: Springer Nature
Release Date : 2020-10-24
Autophagy In Tumor And Tumor Microenvironment written by Sujit Kumar Bhutia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-24 with Medical categories.
This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
The Heterogeneity Of Cancer Metabolism
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Author : Anne Le
language : en
Publisher: Springer
Release Date : 2018-06-26
The Heterogeneity Of Cancer Metabolism written by Anne Le and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-26 with Medical categories.
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.