Metabolomics And Transcriptomics In Biomarker Discovery Mass Spectrometric Techniques In Volatilome Research
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Metabolomics And Transcriptomics In Biomarker Discovery Mass Spectrometric Techniques In Volatilome Research
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Author : Andras Szeitz
language : en
Publisher: Frontiers Media SA
Release Date : 2025-01-30
Metabolomics And Transcriptomics In Biomarker Discovery Mass Spectrometric Techniques In Volatilome Research written by Andras Szeitz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-30 with Science categories.
Metabolites are generated in part during catabolism when the consumed sources of energy undergo biotransformation, energy and metabolites are produced and the latter eliminated from the body. Volatile organic compounds (VOCs), semi-VOCs (SVOCs), etc., can be representatives of the metabolic processes, but also can be generated in pathologic conditions of organisms as signaling agents that transmit potential etiologic information on the disease states of the host. With recent advances in molecular biology and diagnostics, new forms of interdisciplinary science link VOC and SVOC production with genome, transcriptomic and proteomic data sets, and through biomarker discovery, translation and validation coupled with the latest advances in mass spectrometry, they contribute significantly to the emerging area called “volatilome” research. Volatilome research emerges in part from the awareness that organisms emit biomarker VOCs representative of their physiological state, stress conditions, etc., and on the mediating interactions between the host and the environment. For example, human and animal breath contains a vast number of VOCs that translate information about their health, and in case of plants, VOCs can be released in response to an external trigger, such as temperature or osmotic stress, herbivore perturbations, etc. Plant foliar VOCs contribute to potential application in crop stress response, defense, and enhanced biomass production which offers a renewable feedstock for sustainable energy and materials production within a biorefining context. Multi-omics is a valuable tool to investigate the processes involved in the fate of VOCs and their use as potential biomarkers in the inter-species microbiome utilizing the latest technologies in analytical chemistry, such as multidimensional gas or ultra-high performance liquid chromatography coupled with high resolution mass spectrometry.
Periparturient Diseases Of Dairy Cows
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Author : Burim N. Ametaj
language : en
Publisher: Springer
Release Date : 2017-12-21
Periparturient Diseases Of Dairy Cows written by Burim N. Ametaj and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-21 with Science categories.
This book summarizes the results achieved so far by application of various biological systems (including genomics, transcriptomics, proteomics, and metabolomics) involved in the pathomechanisms and early diagnosis of periparturient diseases as specific biomarkers of disease in cattle. These emerging technologies help to extensively enhance our understanding of the etiology and pathogenesis of periparturient diseases of transition dairy cows. The book includes a chapter dedicated to ‘omics’ sciences and one that discusses the myths established in animal and veterinary sciences in recent decades and emerging, new paradigms. The diseases discussed include metritis, mastitis, laminitis, ketosis, rumen acidosis, periparturient immunosuppression, gastrointestinal microbiota and their involvement in disease, infertility, fatty liver, milk fever, and retained placenta. This book is intended for academics, veterinarians, animal nutritionists, researchers, and graduate students working in the field of ‘omics sciences’ with a special interest in dairy cattle health.
The Handbook Of Plant Metabolomics
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Author : Wolfram Weckwerth
language : en
Publisher: John Wiley & Sons
Release Date : 2013-02-28
The Handbook Of Plant Metabolomics written by Wolfram Weckwerth and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-28 with Science categories.
This is the newest title in the successful Molecular Plant Biology Handbook Series. Just like the other titles in the series this new book presents an excellent overview of different approaches and techniques in Metabolomics. Contributors are either from ivy-league research institutions or from companies developing new technologies in this dynamic and fast-growing field. With its approach to introduce current techniques in plant metabolomics to a wider audience and with many labs and companies considering to introduce metabolomics for their research, the title meets a growing market. The Kahl books are in addition a trusted brand for the plant science community and have always sold above expectations.
Wilson And Walker S Principles And Techniques Of Biochemistry And Molecular Biology
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Author : Keith Wilson
language : en
Publisher: Cambridge University Press
Release Date : 2018-04-19
Wilson And Walker S Principles And Techniques Of Biochemistry And Molecular Biology written by Keith Wilson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-19 with Medical categories.
A major update of a best-selling textbook that introduces students to the key experimental and analytical techniques underpinning life science research.
Lipid Analysis
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Author : W. W. Christie
language : en
Publisher: Elsevier
Release Date : 2010-01-10
Lipid Analysis written by W. W. Christie and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-10 with Technology & Engineering categories.
This well-known and highly successful book was first published in 1973 and has been completely re-written in subsequent editions (published in 1982 and 2003). This new Fourth Edition has become necessary because of the pace of developments in mass spectrometry of intact lipids, which has given recognition of lipid analysis and ‘lipidomics’ as a distinct science. To bring the book up to date with these developments, author William W. Christie is joined by co-author Xianlin Han. Although devoting considerable space to mass spectrometry and lipidomics, Lipid analysis remains a practical guide, in one volume, to the complexities of the analysis of lipids. As in past editions, it is designed to act as a primary source, of value at the laboratory bench rather than residing on a library shelf. Lipid analysis deals with the isolation, separation, identification and structural analysis of glycerolipids, including triacylglycerols, phospholipids, sphingolipids, and the various hydrolysis products of these. The chapters follow a logical sequence from the extraction of lipids to the isolation and characterization of particular lipid classes and of molecular species of each, and to the mass spectrometric analysis of lipids and lipidomics. The new influence of mass spectrometry is due mainly to the development of electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI). Most emphasis in this book is placed on ESI, which is enabling structural characterization of different lipid classes and the identification of novel lipids and their molecular species.
Breathborne Biomarkers And The Human Volatilome
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Author : Jonathan Beauchamp
language : en
Publisher: Elsevier
Release Date : 2020-06-06
Breathborne Biomarkers And The Human Volatilome written by Jonathan Beauchamp and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-06 with Science categories.
Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis. - Presents recent advances in the field of breath analysis - Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design - Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments - Acts as both a primer for beginners and a reference for seasoned researchers
Chromatographic Methods In Metabolomics
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Author : Tuulia Hyotylainen
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013
Chromatographic Methods In Metabolomics written by Tuulia Hyotylainen and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Science categories.
Metabolomics is an emerging field and this is the first book to present chromatographic techniques in metabolomics in a fundamental way.
Handbook Of Solid Phase Microextraction
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Author : Janusz Pawliszyn
language : en
Publisher: Elsevier
Release Date : 2011-12-01
Handbook Of Solid Phase Microextraction written by Janusz Pawliszyn and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-01 with Science categories.
The relatively new technique of solid phase microextraction (SPME) is an important tool to prepare samples both in the lab and on-site. SPME is a "green" technology because it eliminates organic solvents from analytical laboratory and can be used in environmental, food and fragrance, and forensic and drug analysis. This handbook offers a thorough background of the theory and practical implementation of SPME. SPME protocols are presented outlining each stage of the method and providing useful tips and potential pitfalls. In addition, devices and fiber coatings, automated SPME systems, SPME method development, and In Vivo applications are discussed. This handbook is essential for its discussion of the latest SPME developments as well as its in depth information on the history, theory, and practical application of the method. - Practical application of Solid Phase Microextraction methods including detailed steps - Provides history of extraction methods to better understand the process - Suitable for all levels, from beginning student to experienced practitioner
Metabonomics
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Author : Jacob T. Bjerrum
language : en
Publisher: Humana
Release Date : 2016-10-05
Metabonomics written by Jacob T. Bjerrum and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-05 with Science categories.
This volume on metabonomics provides detailed information on the procedures involved in nuclear magnetic resonance (NMR) spectroscopy, gas chromatography-mass spectrometry (GS-MS), liquid chromatography-mass spectrometry (LC-MS), and capillary electrophoresis-mass spectrometry (CE-MS). Chapters focus on technologies and chemometrics, generation of metabonomics data, extraction of meaningful information from data, drug development, toxicology, diagnostics, and describing metabonomics as an essential part of systems biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Mass Spectrometry Based Metabolomics In Clinical And Herbal Medicines
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Author : Aihua Zhang
language : en
Publisher: John Wiley & Sons
Release Date : 2021-08-20
Mass Spectrometry Based Metabolomics In Clinical And Herbal Medicines written by Aihua Zhang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-20 with Science categories.
Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.