Metabotropic Glutamate Receptors In The Basal Ganglia

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Metabotropic Glutamate Receptors In The Basal Ganglia

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Author : Claudia Marie Testa
language : en
Publisher:
Release Date : 1996

Metabotropic Glutamate Receptors In The Basal Ganglia written by Claudia Marie Testa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.

Modulation Of Basal Ganglia Function By Metabotropic Glutamate Receptors

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Author : Kari Anne Johnson
language : en
Publisher:
Release Date : 2013

Modulation Of Basal Ganglia Function By Metabotropic Glutamate Receptors written by Kari Anne Johnson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Electronic dissertations categories.

Dopamine Glutamate Interactions In The Basal Ganglia

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Author : Susan Jones
language : en
Publisher: CRC Press
Release Date : 2016-04-19

Dopamine Glutamate Interactions In The Basal Ganglia written by Susan Jones and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.

The basal ganglia are involved in complex brain functions, from voluntary movement control to learning and reward processing, and they are implicated in numerous neurological and psychiatric disorders. Information from the cerebral cortex and thalamus is conveyed to basal ganglia nuclei via glutamate release, while dopamine from the midbrain is rel

Statistics In The Paper Industry

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Author :
language : en
Publisher:
Release Date : 19??

Statistics In The Paper Industry written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 19?? with categories.

Mglu Receptors

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Author : Richard Teke Ngomba
language : en
Publisher: Springer
Release Date : 2017-08-22

Mglu Receptors written by Richard Teke Ngomba and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-22 with Medical categories.

Metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the bain and peripheral tissues. This volume will focus on the latest research in the role of Group I mGluRs in health and disease.

The Role Of Metabotropic Glutamate Receptors Mglurs In The Pathophysiology Of The Basal Ganglia

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Author : Flora Mela
language : en
Publisher:
Release Date : 2005

The Role Of Metabotropic Glutamate Receptors Mglurs In The Pathophysiology Of The Basal Ganglia written by Flora Mela and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.

Metabotropic Glutamate Receptor Mglur4 As A Novel Target For Parkinson S Disease

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Author :
language : en
Publisher:
Release Date : 2001

Metabotropic Glutamate Receptor Mglur4 As A Novel Target For Parkinson S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.

Parkinson's disease (PD) is characterized by a loss of substantia nigra dopaminergic neurons. Here we describe our progress in understanding the role of metabotropic glutamate receptors (mGluRs) as a novel target for the treatment of PD. We have localized mGluR4 in basal ganglia structures, and explored its role in mediating the electrophysiological effects of glutamate in rat brain slices. We have explored the efficacy of mGluR drugs in relieving motor symptoms in hemiparkinsonian monkeys. We found that group III mGluRs are presynaptic on striatal-pallidal terminals and that they mediate a reduction in IPSC amplitude in the SNr. They also pre-synaptically inhibit EPSCs at the STN-SNr synapse. In this study, we have found that groups I and II mGluRs also have critical roles in regulating basal ganglia function. Group II mGluRs mediate a presynaptic reduction of EPSCs in the SNr and group II agonist LY354740 reverses catalepsy in a rodent model of PD. Pre- and Post-synaptic group I mGluRs are involved in regulation of basal ganglia output nuclei by both excitation and disinhibition. Furthermore, comprehensive characterization of the roles of mGluRs in the basal ganglia raises the possibility that they may provide targets for novel therapeutic agents for treatment of PD.

The Basal Ganglia Vii

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Author : Louise F.B. Nicholson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

The Basal Ganglia Vii written by Louise F.B. Nicholson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

This volume, The Basal Ganglia VII, is derived from the proceedings ofthe Seventh Triennial Meeting of the International Basal Ganglia Society (IBAGS). The Meeting was held from II - 15 February 2001 at The Copthorne Resort, Waitangi, Bay of Islands, New Zealand, the site of the signing of the Treaty ofWaitangi in 1840 and the traditional birth-place of the New Zealand Nation. As at previous Meetings, our aim was to hear and discuss new ideas and research developments on the basal ganglia and the implications of these findings for novel treatment strategies for basal ganglia disorders. The International Basal Ganglia Society (IBAGS) was founded in September 1983 when a small group of about 50 neuroscientists and clinicians with a passion for research on the basal ganglia met for a three day meeting in a small isolated seaside resort, Lome, 150km from Melbourne in Australia. The meeting was organised by John McKenzie and was so successful that the participants decided to establish IBAGS and to meet every 3 years at an isolated seaside resort in different countries of the world.

Metabotrobic Glutamate Receptor Mglur4 As A Novel Target For Parkinson S Disease

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Author :
language : en
Publisher:
Release Date : 1999

Metabotrobic Glutamate Receptor Mglur4 As A Novel Target For Parkinson S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.

The symptoms of Parkinson's disease (PD) are associated with a loss of substantia nigra dopaminergic neurons involved in modulation of function of the basal ganglia (BG) . This report describes our progress in understanding the role of metabotropic glutamate receptors (mGluRs) as a novel target for the treatment of PD. Specifically, our aims are to localize mGluR4 in rat and monkey basal ganglia structures, to determine the role of this receptor vs. other subtypes in mediating the electrophysiological effects of glutamate in rat brain slices, and to determine the efficacy of drugs aimed mGluRs in relieving motor symptoms in hemi-parkinsonian monkeys. We found that group III mGluRs are presynaptic on striatal-pallidal terminals and that they mediate a reduction in IPSC amplitude in the SNr. Group III mGluRs also presynaptically inhibit EPSCs at the STN-SNr synapse. Group II mGluRs were found to mediate a presynaptic reduction of EPSCs in the SNr and group II agonist LY354740 reverses catalepsy in an animal model of PD. Furthermore, as these studies progress, the distribution and physiological roles of mGluRs in the BG raises the possibility that these receptors may provide targets for novel therapeutic agents for treatment of PD and related disorders.

Therapeutic Potential Of Targeting Group Iii Metabotropic Glutamate Receptors As A Disease Modifying Strategy In The Treatment Of Parkinson S Disease

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Author : Matthew Thomas John Betts
language : en
Publisher:
Release Date : 2011

Therapeutic Potential Of Targeting Group Iii Metabotropic Glutamate Receptors As A Disease Modifying Strategy In The Treatment Of Parkinson S Disease written by Matthew Thomas John Betts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Glutamic acid categories.

Parkinson's disease (PD) is characterised by a progressive loss of dopaminergic neurones from the SNpc, leading to numerous downstream changes in the basal ganglia circuitry. Overactivity of the glutamatergic subthalamonigral pathway may underlie this continual degeneration of the nigrostriatal system. With this in mind, this thesis examined whether selective activation of group III metabotropic glutamate receptor subtypes may offer a novel strategy to halt persistent degeneration in PD. -- Initial distribution studies revealed mGlu4 and 7 group III mGlu receptor subtypes, demonstrated particularly intense immunoreactivity in the SNpc, suggesting these receptors may be ideally positioned to provide neuroprotective effects. Therefore, the first objective was to confirm this neuroprotective possibility using a broad spectrum agonist, L-AP4. Sub-chronic supranigral L-AP4 treatment mediated functional neuroprotection against a unilateral 6-OHDA lesion of the SN, confirmed by behavioural assessment and post-mortem analyses. -- Secondly, the pharmacological identity of the group III mGlu receptor mediating this protective effect was examined. To investigate mGlu4 receptors, the novel mGlu4 selective PAM VU0155041, was also shown to provide functional neuroprotection in the 6-OHDA rat model to an almost comparable level reached with L-AP4. Whilst these neuroprotective effects are likely mediated by an inhibition of glutamate to protect from glutamate-mediated excitotoxicity, VUO15504 also led to a significant reduction in levels of GFAP and IBA-1 suggesting an additional anti-inflammatory action. Further studies revealed little evidence for co-localisation of mGlu4 receptors with GFAP in the SN suggesting this anti-inflammatory component likely reflects an indirect effect via stimulation of neuronal mGlu4 receptors.