The Role Of Metabotropic Glutamate Receptors Mglurs In The Pathophysiology Of The Basal Ganglia
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The Role Of Metabotropic Glutamate Receptors Mglurs In The Pathophysiology Of The Basal Ganglia
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Author : Flora Mela
language : en
Publisher:
Release Date : 2005
The Role Of Metabotropic Glutamate Receptors Mglurs In The Pathophysiology Of The Basal Ganglia written by Flora Mela and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Modulation Of Basal Ganglia Function By Metabotropic Glutamate Receptors
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Author : Kari Anne Johnson
language : en
Publisher:
Release Date : 2013
Modulation Of Basal Ganglia Function By Metabotropic Glutamate Receptors written by Kari Anne Johnson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Electronic dissertations categories.
Metabotrobic Glutamate Receptor Mglur4 As A Novel Target For Parkinson S Disease
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Author :
language : en
Publisher:
Release Date : 1999
Metabotrobic Glutamate Receptor Mglur4 As A Novel Target For Parkinson S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
The symptoms of Parkinson's disease (PD) are associated with a loss of substantia nigra dopaminergic neurons involved in modulation of function of the basal ganglia (BG) . This report describes our progress in understanding the role of metabotropic glutamate receptors (mGluRs) as a novel target for the treatment of PD. Specifically, our aims are to localize mGluR4 in rat and monkey basal ganglia structures, to determine the role of this receptor vs. other subtypes in mediating the electrophysiological effects of glutamate in rat brain slices, and to determine the efficacy of drugs aimed mGluRs in relieving motor symptoms in hemi-parkinsonian monkeys. We found that group III mGluRs are presynaptic on striatal-pallidal terminals and that they mediate a reduction in IPSC amplitude in the SNr. Group III mGluRs also presynaptically inhibit EPSCs at the STN-SNr synapse. Group II mGluRs were found to mediate a presynaptic reduction of EPSCs in the SNr and group II agonist LY354740 reverses catalepsy in an animal model of PD. Furthermore, as these studies progress, the distribution and physiological roles of mGluRs in the BG raises the possibility that these receptors may provide targets for novel therapeutic agents for treatment of PD and related disorders.
The Metabotropic Glutamate Receptors
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Author : P. Jeffrey Conn
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
The Metabotropic Glutamate Receptors written by P. Jeffrey Conn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
The Metabotropic Glutamate Receptors offers state-of-the-art summaries and reviews of virtually everything known today about metabotropic glutamate receptors (mGluRs), including their molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles. Illuminating the overall role played by this crucial class of receptors in brain function, the book also pinpoints those areas in which there is the greatest continuing need for focused research. Because mGluRs have the potential for participating in virtually all known functions of the central nervous system (CNS), the opportunity now exists to develop pharmacological agents that can potentially alter many brain disease processes by selective interaction with precise CNS functions. With its critical and insightful reviews, The Metabotropic Glutamate Receptors will immediately become your essential key to the development of novel treatment strategies for the widest variety of neurological disorders.
Metabotropic Glutamate Receptor Mglur4 As A Novel Target For Parkinson S Disease
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Author :
language : en
Publisher:
Release Date : 2001
Metabotropic Glutamate Receptor Mglur4 As A Novel Target For Parkinson S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Parkinson's disease (PD) is characterized by a loss of substantia nigra dopaminergic neurons. Here we describe our progress in understanding the role of metabotropic glutamate receptors (mGluRs) as a novel target for the treatment of PD. We have localized mGluR4 in basal ganglia structures, and explored its role in mediating the electrophysiological effects of glutamate in rat brain slices. We have explored the efficacy of mGluR drugs in relieving motor symptoms in hemiparkinsonian monkeys. We found that group III mGluRs are presynaptic on striatal-pallidal terminals and that they mediate a reduction in IPSC amplitude in the SNr. They also pre-synaptically inhibit EPSCs at the STN-SNr synapse. In this study, we have found that groups I and II mGluRs also have critical roles in regulating basal ganglia function. Group II mGluRs mediate a presynaptic reduction of EPSCs in the SNr and group II agonist LY354740 reverses catalepsy in a rodent model of PD. Pre- and Post-synaptic group I mGluRs are involved in regulation of basal ganglia output nuclei by both excitation and disinhibition. Furthermore, comprehensive characterization of the roles of mGluRs in the basal ganglia raises the possibility that they may provide targets for novel therapeutic agents for treatment of PD.
Mglu Receptors
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Author : Richard Teke Ngomba
language : en
Publisher: Springer
Release Date : 2017-08-22
Mglu Receptors written by Richard Teke Ngomba and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-22 with Medical categories.
Metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the bain and peripheral tissues. This volume will focus on the latest research in the role of Group I mGluRs in health and disease.
Metabotropic Glutamate Receptors In The Basal Ganglia
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Author : Claudia Marie Testa
language : en
Publisher:
Release Date : 1996
Metabotropic Glutamate Receptors In The Basal Ganglia written by Claudia Marie Testa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Metabotropic Glutamate Receptors
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Author : Jordan O'Keeffe
language : en
Publisher:
Release Date : 2018
Metabotropic Glutamate Receptors written by Jordan O'Keeffe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Glutamic acid categories.
Metabotropic Glutamate Receptors: Classification, Structure and Roles in Disease focuses on Glutamate (Glu), a neurotransmitter/neuromodulator the most widely present in neurons of excitatory pathways, both in the central and peripheral nervous system. The authors present and discuss the molecular structure of some glutamatergic receptors, their distribution, specificity and molecular mechanisms of the physiological and pathological effects of Glu in health and illness. The specific and nonspecific agonist/antagonist receptors utility are also discussed. Following this, the recent outcomes on the role of mGlu7 and mGlu8 receptors on pain transmission and affective/cognitive disorders are summarized. Particular emphasis is placed on their modulation within the antinociceptive descending system, an endogenous anatomical substrate whose pharmacological manipulation may strategically silence pain. In the concluding chapter, the authors reviewed the roles of Metabotropic Glutamate Receptors (mGluRs) and their related signal transduction pathways or interacting proteins in the pathogenesis of the status epilepticus and temporal lobe epilepsy. Some novel therapeutical drug targets for controlling epilepsy and epileptogenesis are proposed.
Metabotropic Glutamate Receptors And Brain Function
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Author : Flavio Moroni
language : en
Publisher: Ashgate Publishing
Release Date : 1998
Metabotropic Glutamate Receptors And Brain Function written by Flavio Moroni and has been published by Ashgate Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Brain chemistry categories.
The aim of this book is to provide a broad and complete overview of research on metabotropic glutamate receptors (mGluRs). The information collected in it should contribute to the development of research in the mGluR area and provide scientists with a tool for a better understanding of this system and a broader perspective in the search for new approaches in the treatment of neurological and psychiatric disorders.
Metabotropic Glutamate Receptors
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Author : M. Foster Olive
language : en
Publisher: Nova Science Publishers
Release Date : 2014
Metabotropic Glutamate Receptors written by M. Foster Olive and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Glutamic acid categories.
As the most abundant excitatory neurotransmitter in the brain, glutamate plays an important role in numerous aspects of normal and pathological brain function. This book provides an overview of the role of metabotropic glutamate receptors (mGluRs) in basic brain functioning, such as autonomic regulation, synaptic plasticity, and learning and memory. Also provided are up-to-date summaries of recent progress towards identifying how mGluRs both mediate and represent novel pharmacotherapeutic targets for the treatment of various neurological and neuropsychiatric disorders, such as depression, anxiety, schizophrenia, amyloidogenic disorders and substance abuse.