Metabotropic Glutamate Receptors
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Metabotropic Glutamate Receptors
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Author : Andrius Baskys
language : en
Publisher: R. G. Landes
Release Date : 1994
Metabotropic Glutamate Receptors written by Andrius Baskys and has been published by R. G. Landes this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
The Metabotropic Glutamate Receptors
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Author : P. Jeffrey Conn
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
The Metabotropic Glutamate Receptors written by P. Jeffrey Conn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
The Metabotropic Glutamate Receptors offers state-of-the-art summaries and reviews of virtually everything known today about metabotropic glutamate receptors (mGluRs), including their molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles. Illuminating the overall role played by this crucial class of receptors in brain function, the book also pinpoints those areas in which there is the greatest continuing need for focused research. Because mGluRs have the potential for participating in virtually all known functions of the central nervous system (CNS), the opportunity now exists to develop pharmacological agents that can potentially alter many brain disease processes by selective interaction with precise CNS functions. With its critical and insightful reviews, The Metabotropic Glutamate Receptors will immediately become your essential key to the development of novel treatment strategies for the widest variety of neurological disorders.
Metabotropic Glutamate Receptors And Neurological Psychiatric Disorders
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Author : Enza Palazzo
language : en
Publisher: Frontiers Media SA
Release Date : 2019-06-19
Metabotropic Glutamate Receptors And Neurological Psychiatric Disorders written by Enza Palazzo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-19 with categories.
Considering that neurological and psychiatric illnesses do not still have efficient therapies and are becoming increasingly widespread, the search for novel targets appears fundamental. Neuroinflammation, alterations in adult neurogenesis and excitotoxicity, all associated with glutamate transmission dysfunction, are key components of the pathogenetic mechanisms underlying neuropsychiatric illnesses. Counteracting the neurotoxic actions of glutamate through the modulatory actions of metabotropic glutamate receptors (mGluRs), represents a rational intervention that offers tolerability compatible with clinical therapy. Their suitability as targets for developing novel therapies is also based on the fact that mGluRs are found abundantly expressed in synapses of the central nervous system (CNS) that are considered critical in certain neurological and psychiatric disorders. Moreover, recently there has been an exponential development of selective ligands, especially positive and negative allosteric modulators, which by binding to less conserved transmembrane domain sequences ensure, besides a good permeability in the CNS, an adequate selectivity for each mGluR subtype. The eBook “Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders”, collects contributes (original and review articles) on the beneficial effects of positive and negative allosteric modulators of mGluRs in animal models of neurological and psychiatric diseases from renown experts in the field. The hope is that the effort of both Editors and Contributors of this eBook confirms the unlimited potential of mGluRs in CNS diseases and generate a collaborative discussion on the state of art, overall trends, novel strategies, and future direction of this attractive field of research.
The Metabotropic Glutamate Receptors
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Author : P. Jeffrey Conn
language : en
Publisher:
Release Date : 1994-09-29
The Metabotropic Glutamate Receptors written by P. Jeffrey Conn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-09-29 with categories.
Metabotropic Glutamate Receptors
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Author : Jordan O'Keeffe
language : en
Publisher:
Release Date : 2018
Metabotropic Glutamate Receptors written by Jordan O'Keeffe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Glutamic acid categories.
Metabotropic Glutamate Receptors: Classification, Structure and Roles in Disease focuses on Glutamate (Glu), a neurotransmitter/neuromodulator the most widely present in neurons of excitatory pathways, both in the central and peripheral nervous system. The authors present and discuss the molecular structure of some glutamatergic receptors, their distribution, specificity and molecular mechanisms of the physiological and pathological effects of Glu in health and illness. The specific and nonspecific agonist/antagonist receptors utility are also discussed. Following this, the recent outcomes on the role of mGlu7 and mGlu8 receptors on pain transmission and affective/cognitive disorders are summarized. Particular emphasis is placed on their modulation within the antinociceptive descending system, an endogenous anatomical substrate whose pharmacological manipulation may strategically silence pain. In the concluding chapter, the authors reviewed the roles of Metabotropic Glutamate Receptors (mGluRs) and their related signal transduction pathways or interacting proteins in the pathogenesis of the status epilepticus and temporal lobe epilepsy. Some novel therapeutical drug targets for controlling epilepsy and epileptogenesis are proposed.
Metabotropic Glutamate Receptors And Brain Function
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Author : Flavio Moroni
language : en
Publisher: Ashgate Publishing
Release Date : 1998
Metabotropic Glutamate Receptors And Brain Function written by Flavio Moroni and has been published by Ashgate Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Brain chemistry categories.
The aim of this book is to provide a broad and complete overview of research on metabotropic glutamate receptors (mGluRs). The information collected in it should contribute to the development of research in the mGluR area and provide scientists with a tool for a better understanding of this system and a broader perspective in the search for new approaches in the treatment of neurological and psychiatric disorders.
Mglu Receptors
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Author : Richard Teke Ngomba
language : en
Publisher: Springer
Release Date : 2017-08-22
Mglu Receptors written by Richard Teke Ngomba and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-22 with Medical categories.
Metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the bain and peripheral tissues. This volume will focus on the latest research in the role of Group I mGluRs in health and disease.
Metabotropic Glutamate Receptor Technologies
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Author : M. Foster Olive
language : en
Publisher:
Release Date : 2021
Metabotropic Glutamate Receptor Technologies written by M. Foster Olive and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Electronic books categories.
This volume highlights various techniques used to study multiple aspects of mGlu receptor function. Chapters in this book cover topics such as modern approaches for the development and screening of allosteric modulators; fluctuations in intracellular calcium induced by mGlu receptor activation; dopamine-glutamate interactions in the central nervous system; methods for assessing mGlu receptor localization; and common techniques for evaluating mGlu modulation in behavior in rodents, including stress and alcohol drinking. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Metabotropic Glutamate Receptor Technologies provides researchers with a starting point to address important questions regarding mGlu and its importance. Researchers working in the fields of neuroscience and physiology of multiple peripheral systems will find this volume most useful. .
Metabotropic Glutamate Receptors In The Basal Ganglia
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Author : Claudia Marie Testa
language : en
Publisher:
Release Date : 1996
Metabotropic Glutamate Receptors In The Basal Ganglia written by Claudia Marie Testa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Metabotropic Glutamate Receptors
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Author : M. Foster Olive
language : en
Publisher: Nova Science Publishers
Release Date : 2014
Metabotropic Glutamate Receptors written by M. Foster Olive and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Glutamic acid categories.
As the most abundant excitatory neurotransmitter in the brain, glutamate plays an important role in numerous aspects of normal and pathological brain function. This book provides an overview of the role of metabotropic glutamate receptors (mGluRs) in basic brain functioning, such as autonomic regulation, synaptic plasticity, and learning and memory. Also provided are up-to-date summaries of recent progress towards identifying how mGluRs both mediate and represent novel pharmacotherapeutic targets for the treatment of various neurological and neuropsychiatric disorders, such as depression, anxiety, schizophrenia, amyloidogenic disorders and substance abuse.