Metal Compounds In Cancer Therapy
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Metal Compounds In Cancer Therapy
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Author : S.P. Fricker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Metal Compounds In Cancer Therapy written by S.P. Fricker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The discovery of the antitumour activity of cisplatin in 1965 and its subsequent introduction into clinical trials in 1971 was the catalyst for a major international research effort investigating the potential of metal compounds in cancer therapy. Cisplatin now occupies an important place in the armamentarium of the oncologist due to its effectiveness in the treatment of testicular cancer. A second generation analogue, carbo platin, offers reduced toxicity together with therapeutic activity, which gives it a place in the front-line therapy of genitourinary cancers. These and other successes have encouraged the search for novel metal-based drugs for cancer therapy. Research has shown that metal compounds have potential for activity not only as cytotoxic antitumour agents, but also in areas such as adjuvant therapy, diagnosis and immunotherapy. The aim of this book is to review and describe the major achievements and developments arising from this international research effort. The contributing authors come from labora tories throughout Europe and America and represent the many disci plines characteristic of this research, such as clinical research, pharmacology, tumour biology and inorganic medicinal chemistry.
Metal Compounds In Cancer Therapy
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Author : S P Fricker
language : en
Publisher:
Release Date : 1994-11-30
Metal Compounds In Cancer Therapy written by S P Fricker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-11-30 with categories.
The discovery of the anti-tumour activity of cisplatin in 1965 and its subsequent introduction into clinical trials in 1971 was the catalyst for a major research effort into the potential of metal compounds in cancer therapy. This book draws together information on all metals involved in cancer therapy, including those used in radioisotopes. Throughout an interdisciplinary approach has been taken to reflect the nature of this research. This book will provide an invaluable reference source for anyone interested in the role of metals in oncotherapy.
Platinum And Other Heavy Metal Compounds In Cancer Chemotherapy
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Author : Andrea Bonetti
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-01-09
Platinum And Other Heavy Metal Compounds In Cancer Chemotherapy written by Andrea Bonetti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-09 with Medical categories.
Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the treatment of ovarian cancers and other gynecologic cancers, head and neck, and numerous other tumor types. The development of carboplatin has reduced some of the adverse events associated with cisplatin treatment, and the introduction of the DACH platinum compound oxaliplatin has broadened the spectrum of activity of the platinums to include gastro-intestinal cancers, especially colorectal cancer. The clinical importance of this family of drugs continues to drive investigation into how these drugs work and how to improve their efficacy and reduce their toxicity. The papers in this volume were presented in Verona, Italy, during the tenth International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy. The symposium was jointly organized by the Department of Oncology of the Mater Salutis Hospital – Azienda Sanitaria Locale 21 of the Veneto Region – and by the Department of Medicine and Public Health, Section of Pharmacology, the University of Verona. They reflect the vitality of this field and the increasing use of new molecular and cell biologic, genetic, and biochemical tools to identify approaches to further improve their use.
Metal Complexes In Cancer Chemotherapy
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Author : Bernhard K. Keppler
language : en
Publisher: VCH Publishers
Release Date : 1993
Metal Complexes In Cancer Chemotherapy written by Bernhard K. Keppler and has been published by VCH Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
Platinum And Other Metal Coordination Compounds In Cancer Chemotherapy
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Author : Stephen B. Howell
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Platinum And Other Metal Coordination Compounds In Cancer Chemotherapy written by Stephen B. Howell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.
Ruthenium And Other Non Platinum Metal Complexes In Cancer Chemotherapy
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Author : Etienne Baulieu
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-07
Ruthenium And Other Non Platinum Metal Complexes In Cancer Chemotherapy written by Etienne Baulieu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
With contributions by numerous experts
Metal Complexes In Cancer Therapy
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Author : Bernhard K. Keppler
language : en
Publisher:
Release Date : 1993
Metal Complexes In Cancer Therapy written by Bernhard K. Keppler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Antineoplastic agents categories.
Metal Based Anticancer Agents
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Author : Angela Casini
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-04-23
Metal Based Anticancer Agents written by Angela Casini and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-23 with Science categories.
Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.
Platinum And Other Metal Coordination Compounds In Cancer Chemotherapy 2
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Author : Steef van de Velde
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Platinum And Other Metal Coordination Compounds In Cancer Chemotherapy 2 written by Steef van de Velde and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
The 7th International Symposium on Platinum and other metal coordination compounds in Cancer Chemotherapy, ISPCC '95, organized by the European Cancer Centre, was held in Amsterdam, the Netherlands, March 1-4, 1995. As with previous ISPCC meetings, the goal of ISPCC '95 was to bring together c1inicians, clinical investigators, scientists, and laboratory workers from many disciplines to promote further collaboration and cooperation in the development of new platinum and other metal coordination compounds as weil as in new ways to use 'c1assical' drugs as cisplatin and carboplatin in the treatment of cancer. Important aspects addressed by experts in the field inc1uded the synthesis and activity of new platinum compounds, the biochemistry and molecular pharrnacology as weil as the c1inical pharrnacology of this c1ass of antineoplastic agents, an overview of current c1inical studies, one special minisymposium on the mechanisms of cell kill of platinum, and one on resistance against platinum compounds. Finally, the current status of development of nonplatinum metal complexes was discussed. This volume contains the contributions of the various speakers at ISPCC '95 and provides an up-to-date and comprehensive overview of this important c1ass of anticancer agents, ranging from synthesis and molecular pharrnacology on one hand to c1inical pharrnacology and cIinical investigations on the other hand. The Organizing Corrunittee and Editors wish to express their gratitude to the contributors to this volume, to the various organizations and pharrnaceutical companies for their generous sponsoring of ISPCC '95, and to the Plenum Publishing Company for their help in producing this volume.
Chemistry Of Biologically Potent Natural Products And Synthetic Compounds
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Author : Shahid Ul-Islam
language : en
Publisher: John Wiley & Sons
Release Date : 2021-06-29
Chemistry Of Biologically Potent Natural Products And Synthetic Compounds written by Shahid Ul-Islam and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-29 with Science categories.
In view of their promising biological and pharmaceutical activities, natural product inspired and heterocyclic compounds have recently gained a reputation in the field of medicinal chemistry. Over the past decades, intensive research efforts have been ongoing to understand the synthesis, biochemistry and engineering involved in their preparation and action mechanisms. Several novel natural product derivatives, heterocyclic and other synthetic compounds, have been reported to have shown interesting biological activities including anticancer, antimicrobial, anti-inflammatory, anti-glycemic, anti-allergy and antiviral etc. Chemistry of Biologically Potent Natural Products and Synthetic Compounds provides up-to-date information on new developments and most recent medicinal applications of the natural products and derivatives, as well as the chemistry and synthesis of heterocyclic and other related compounds.