Metal Transporters
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Metal Transporters
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-10-05
Metal Transporters written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-05 with Science categories.
This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise
Metal Transport In Plants
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Author : Tomoko Nozoye
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-01
Metal Transport In Plants written by Tomoko Nozoye and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-01 with Science categories.
Metal And Nutrient Transporters In Abiotic Stress
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Author : Aryadeep Roychoudhury
language : en
Publisher: Academic Press
Release Date : 2021-04-08
Metal And Nutrient Transporters In Abiotic Stress written by Aryadeep Roychoudhury and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-08 with Science categories.
Metal and Nutrient Transporters in Abiotic Stress focuses on the different forms of environmental stress related to heavy metal, metalloid and nutrient deficiency that have the potential to inflict major damages to crop plants, leading to a massive decrease in crop yield and productivity. The book presents the current state of knowledge of the biochemical and molecular regulation of several classes of membrane transporters related to the uptake of metals/metalloids and nutrient elements during different stresses and their probable mechanisms of operation in plant stress tolerance. Metal and Nutrient Transporters in Abiotic Stress provides a comprehensive discussion that will help in mitigating multiple forms of stresses utilizing transporter proteins. Edited by leading experts and written by a global team of knowledgeable contributors, this book will further stimulate research in the field of transporter proteins and will foster further interests for researchers, academicians and scientists worldwide. It is complimented by its companion book titled Transporters and Plant Osmotic Stress. Focuses exclusively on metal and nutrient transporters involved in multiple environmental stresses in plants Explains exploiting transporters in crop improvement programs through transgenic technology against different stresses such as heavy metal, metalloid and nutrient deficiency Serves as an important source of information in the field of abiotic stress
Plant Metal And Metalloid Transporters
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Author : Kundan Kumar
language : en
Publisher: Springer Nature
Release Date : 2022-10-29
Plant Metal And Metalloid Transporters written by Kundan Kumar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-29 with Science categories.
This edited book stands as a one place knowledge hub for plant metal(loid) transporters. The book comprehensively covers holistic aspect of metal(loid) transporters involved in uptake and translocation of essential as well as toxic metal(loid)s. Essential and beneficial metal(loid)s are required in every biological process for normal plant growth and development, however in excess they are toxic. There are toxic metal(loid)s also whose accumulation in plants interferes with normal cellular functioning and hampers growth of plants. Hence, metal(loid) uptake and accumulation in plants is a highly regulated phenomenon involving the role of several transporters, enzymes, metabolites, transcription factors and post translational modifications. The book contains chapters from the experts and the contents of the book are presented in simple language and represented through beautiful and scientifically informative figures and tables. This book is of interest to teachers, researchers, doctoral and graduate students working in the area of plant physiology, environmental biotechnology, plant biotechnology metal(loid) stress, phytoremediation and crop biofortification.
Zip Metal Ion Transporters
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-09-05
Zip Metal Ion Transporters written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-05 with Science categories.
ZIP Metal Ion Transporters, Volume 684 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Biochemistry, Biophysics and Structural Biology, Structure determination of a bacterial ZIP in lipidic cubic phase, Cell-based metal transport assay for animal and plant ZIPs, Measurement of metal binding affinity and transport activity in ZIP transporters using spectroscopic methods, Considerations in production of the (prokaryotic) ZIP family transporters for structural and functional studies, Metal-protein interactions investigated using model systems: thermodynamic, spectroscopic and computational methods, and more. Additional chapters cover Getting Zinc Into and Out of Cells, In-silico modeling of ZIP9 (TBD), Cellular Function and Regulation, Methods to visualize zinc transporter proteins of the SLC39A family in cells, Assessing metal ion transporting activity of ZIPs: intracellular zinc and iron detection, In vitro studies for studying manganese transport and homeostasis, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Updated release includes the latest information on ZIP Metal Ion Transporters
Heavy Metal Remediation
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Author : Dhamendra Kumar Gupta
language : en
Publisher: Nova Science Pub Incorporated
Release Date : 2014-01-01
Heavy Metal Remediation written by Dhamendra Kumar Gupta and has been published by Nova Science Pub Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-01 with Science categories.
Plants have a very specific and efficient mechanism to obtain, translocate and store nutrients from the surrounding environment. The precise mechanism that helps a plant in nutrient translocation from root to shoot also, in the same way, transfers and stores toxic metals within their structure. Metal toxicity generally causes multiple direct or indirect effects on plants, affecting nearly all of their physiological functions. Plant tolerance to heavy metals depends largely on plant efficiency in uptake, translocation and sequestration of heavy metals in specific cell organelles or specialized tissues. The main purpose of this book is to present a holistic view of the recent advancement in the field of accumulation and remediation using plants, the green solar powered alternative to ameliorate heavy metal from the polluted environment. The key features of the book are related to metal transporters and metal accumulation mechanisms under heavy metal stress in plants, plant transcriptional regulation and responses under metal contamination, multiple toxic metal contaminations and its phytoremediation approaches etc. Based on the advancement of research in recent years, the information compiled in this book will bring an in-depth knowledge on the bioaccumulation of metals, their transportation in natural conditions or genetically modified plants and their strategy to cope with the toxicity to survive in the hostile environment.
Biochemical And Biophysical Characterization Of Bacterial Transition Metal Transporters By Functional Reconstitution In Artificial Lipid Bilayers
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Author : Nisansala Sandamali Abeyrathna
language : en
Publisher:
Release Date : 2022
Biochemical And Biophysical Characterization Of Bacterial Transition Metal Transporters By Functional Reconstitution In Artificial Lipid Bilayers written by Nisansala Sandamali Abeyrathna and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Bilayer lipid membranes categories.
Transition metals play a vital role in all living organisms due to their key structural and functional properties central to diverse metabolic processes. However, because of their high reactivity organisms have evolved sophisticated biomolecular protein networks to control intercellular metal ion homeostasis, without reaching toxic intracellular levels. Transmembrane transporter proteins play a gate-keeper role in maintaining the dynamic flux of these transition metal ions across biological membranes, thereby finely tuning metal delivery and availability in cells and subcellular organelles. P-type ATPases are a superfamily of transmembrane primary active transporters involved in translocating substrates against an electrochemical gradient which play a key role in maintaining homeostasis of cellular concentrations of essential ions. They are classified into 5 classes (P1, P2, P3, P4 and P5) based on their substrate selectivity. This dissertation is focused on studying the substrate selectivity and mechanism of translocation in the P1B class of P-type ATPases which are involved in transition metal transport for both essential and toxic transition metals. P1B-type ATPases are classified into 7 sub families (P1B-1 - P1B-7 types) based on conserved amino acid motifs in their transmembrane helices that appear to control each sub-family’s substrate selectivity, resulting in the existence of pumps that can selectively translocate 1st, 2nd and 3rd row transition metals across the lipid bilayer. Considering their central role in controlling cellular metal levels and extrusion in cells they are also acting as virulence factors in pathogenic bacteria. Studies towards their characterization could therefore help in establishing them as new potential therapeutic targets to develop novel antibiotics to overcome the bacterial resistance observed with traditional antibiotics. However, the substrate transport across lipid bilayers, the overall mechanism for cargo translocation, and kinetics of these transporters remain elusive to a significant extent, due to lack of molecular tools to study putative metal substrate transport across membranes in real-time in a native-like environment. In light of this, metal-stimulated ATPase activity assays were coupled with an experimental platform based on multiple fluorescence sensor probes, to study substrate selectivity, transport mechanism, including counterion transport and electrogenicity, and translocation kinetics in realtime with recombinantly expressed proteins belonging to P1B-1 (CopA from E. coli) and P1B-5 (Nia from S. meliloti) classes reconstituted in artificial lipid bilayer vesicles known as proteoliposomes. The proteoliposomes were used as an in-vitro tool to determine metal selectivity and the kinetic parameters for metal transport by encapsulating fluorescent detector probes featuring turn-on florescence signal upon substrate ion binding and translocation. However, the use of the proteoliposomes is challenging due to their intrinsic structural instability and susceptibility to stressors like temperature, aging, and chemicals, which limits their shelf life. Therefore, an experimental approach was developed to stabilize membrane proteins and proteoliposomes by encapsulating them in a sheddable metal organic framework, which reduces their susceptibility to external stressors. This platform sheds light on developing methods to utilize proteoliposomes in biochemical and biophysical investigation of transmembrane proteins and in drug delivery applications. In addition, this approach would help to overcome the challenges of cold-chain therapeutic transport of liposomal vaccine formulations.
Metal Transporters
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Author : Jose M. Arguello
language : en
Publisher: Academic Press
Release Date : 2012-10-25
Metal Transporters written by Jose M. Arguello and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-25 with Science categories.
This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise
The Nramp Family
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Author : Mathieu Cellier
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-08-25
The Nramp Family written by Mathieu Cellier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-25 with Science categories.
This book is the first comprehensive volume on the "Nramp family", highlighting the physiological importance of Nramp proteins as metal transporters. The molecular knowledge of these membrane proteins is presented from an evolutionary perspective, considering Nramp cellular function and mechanism of transport in key model organisms. The pathological significance of Nramp genetic polymorphism is discussed with emphasis on metal homeostasis and microbial infection. The chapters were contributed by leading investigators, providing a timely state of the art book in this rapidly growing field. The Nramp Family will be useful to a broad community of scientists interested in metal transport and molecular biology. It will be of interest to the research audience in the broad fields of metal ions and molecular medicine.
Metal Transport In The Hyperaccumulator Plant Thlaspi Caerulescens
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Author : Barbara Leitenmaier
language : en
Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
Release Date : 2012
Metal Transport In The Hyperaccumulator Plant Thlaspi Caerulescens written by Barbara Leitenmaier and has been published by Sudwestdeutscher Verlag Fur Hochschulschriften AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
In this thesis, various aspects on heavy metal accumulation by the hyperaccumulator plant Thlaspi caerulescens have been investigated. T. caerulescens belongs to the family of Brassicaceae and hyperaccumulates zinc. Its ecotype Ganges, originating from Southern France, additionally takes up cadmium actively. It is known from previous studies that hyperaccumulators have highly overexpressed metal transporters and that most of them store the metal in the vacuole of large epidermal cells. First, the long-term behaviour of T. caerulescens upon cadmium treatment has been studied and via chlorophyll-fluorescence-kinetic-measurements, it could be shown that, after showing symptoms of toxicity, the plants acclimated to the metal stress and the symptoms of toxicity vanished. Further, using a Cd-specific dye, the timelimiting step in hyperaccumulation could be identified as the transport of metal into the vacuole. Isolating and characterising a Cd/Zn-ATPase from plant roots, it could be shown using various techniques like UV/Vis spectroscopy and EXAFS, that the protein is not only activated by Cd and Zn, but by Cu as well. Cd in the protein is mainly bound by cysteines, Zn by histidines.