Metastatic Cancer Clinical And Biological Perspectives
DOWNLOAD
Download Metastatic Cancer Clinical And Biological Perspectives PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Metastatic Cancer Clinical And Biological Perspectives book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Metastatic Cancer Clinical And Biological Perspectives
DOWNLOAD
Author : Rahul Jandial
language : en
Publisher: CRC Press
Release Date : 2013-08-08
Metastatic Cancer Clinical And Biological Perspectives written by Rahul Jandial and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-08 with Medical categories.
Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.
Cancer Metastasis
DOWNLOAD
Author : Volker Schirrmacher
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cancer Metastasis written by Volker Schirrmacher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
These are the Proceedings of the 2nd International Metastasis Congress of the Metastasis Research Society which took place in the town hall (Stadthalle) of Heidelberg, FRG, in September, 1988. This first Metastasis Congress in the FRG was organized in conjunction with the German Association of Cancer Research (SEK) of the German Cancer Society. The congress topic generated tremendous interest and attracted about 400 scientists from 22 countries. Most participants came from Europe, Israel, and the United States. Why did we organize the Metastasis Congress? Only about 50% of all people who develop some form of cancer are curable. Despite improved patient care and increasingly innovative and effective techniques for diagnosing and treating primary cancers, the development of secondary cancer colonies, i. e. , metastasis, can not be prevented and is the major cause of death. In the Federal Republic of Germany there are still as many as 160 000 cancer patients per year who succumb to their disease, often after periods of terrible suffering, and this overall figure is not improving. Partly because of the complexity of the process, basic research on metastasis has lagged behind other disciplines such as carcino genesis and cancer genetics. Metastasis formation involves the ability of malig nant cells to invade adjacent tissue and to penetrate into lymphatic or blood circulatory systems, or both, and to spread to near or distant sites to form new tumor colonies. Meanwhile, research on metastasis is receiving much attention.
Central Nervous System Metastasis The Biological Basis And Clinical Considerations
DOWNLOAD
Author : Diane Palmieri
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-30
Central Nervous System Metastasis The Biological Basis And Clinical Considerations written by Diane Palmieri and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-30 with Medical categories.
Here is a thorough survey of the biology and treatment of CNS metastasis, including natural history, risk factors, molecular biology, the blood-brain barrier, imaging, quality of life, surgery, chemotherapy, radiation and the future of targeted therapies.
Introduction To Cancer Metastasis
DOWNLOAD
Author : Aamir Ahmad
language : en
Publisher: Academic Press
Release Date : 2016-11-14
Introduction To Cancer Metastasis written by Aamir Ahmad and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-14 with Medical categories.
Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe
Signaling Pathways And Molecular Mediators In Metastasis
DOWNLOAD
Author : Alessandro Fatatis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-02
Signaling Pathways And Molecular Mediators In Metastasis written by Alessandro Fatatis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-02 with Medical categories.
This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.
Cancer Metastasis Through The Lymphovascular System
DOWNLOAD
Author : Stanley P. Leong
language : en
Publisher: Springer Nature
Release Date : 2022-06-24
Cancer Metastasis Through The Lymphovascular System written by Stanley P. Leong and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-24 with Medical categories.
This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions.
Cancer Metastasis
DOWNLOAD
Author : G. Prodi
language : en
Publisher: Springer
Release Date : 1988-07
Cancer Metastasis written by G. Prodi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-07 with Medical categories.
The study of metastases now being vigorously pursued and the centre of much renewed interest is the essence of malignancy. Understanding how metastases develop and what can be done to control them is of vital importance to all oncologists. The reason for this renewed interest is due not only to the relevance of the problem, but is in part due to progress in other fields and their impact on metastases research. Metastasis is a phase in the progression of tumors and can be viewed as the final step in the pathology of malignancy. The various phases of the progression of tumors now appear more and more s parts of the total process of carcinogenesis, beginning with initiation and reaching stepwise the extreme condition of metastatic spread. The problem is therefore not only describing a biologic process, but to explain it in terms of mechanism. In this sense, fields which were far removed from the problems of metastasis are now part of it (e.g. genetics of metastasizing cell, oncogene expression, molecular biology of membrane etc.) The International Congress on Cancer Metastasis - Biological and Biochemical Mechanisms and Clinical Aspects, held in Bologna in My 1987 offered a comprehensive overview of the different aspects of the field. Special emphasis is given in this volume to the biology of metastasis and its relevance to treatment.
Experimental Metastasis Modeling And Analysis
DOWNLOAD
Author : Anastasia Malek
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-02
Experimental Metastasis Modeling And Analysis written by Anastasia Malek and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-02 with Medical categories.
Metastatic dissemination of cancer is a main cause of cancer related deaths, therefore biological mechanisms implicated in metastatic process presents an essential object of cancer research. This research requires creation and utilization of adequate laboratory models. The book describes main approaches to model processes of metastatic cancer dissemination and metastases development. The book is structured in according with various metastatic pathways reflecting molecular specificity of metastatic process as well as anatomical specificity of aria of dissemination. Each chapter is introduced by short discussion of clinical aspects of certain metastatic pathway. Especial attention is paid for methods of visualization, quantification and analysis of the modeled metastases. Additional chapter is devoted to methods of mathematic modeling of tumor spread. The data presented in the book may be helpful for cancer researchers and oncologists.
Cancer Metastasis Molecular And Cellular Mechanisms And Clinical Intervention
DOWNLOAD
Author : Wen G. Jiang
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
Cancer Metastasis Molecular And Cellular Mechanisms And Clinical Intervention written by Wen G. Jiang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.
This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.
Understanding Cancer
DOWNLOAD
Author : David Tarin
language : en
Publisher: Springer Nature
Release Date : 2023-02-02
Understanding Cancer written by David Tarin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-02 with Medical categories.
This book provides a unique, wide-ranging description of the phenomenon of cancer and its pathological effects in diverse species including humans, domesticated and wild animals, invertebrates, and plants. The broad scope of information presented is used to construct radical new insights into biological self-regulation and explain their relevance to its disruption by cancerous growth and spread within the human body. Mechanisms of action of carcinogenic agents, initiation, progression, metastasis, inappropriate gene expression, dormancy, latency, regression, and reasons for susceptibility and/or resistance to cancer are all considered. Also discussed are criteria for pathological diagnosis, advances in treatment, implications for public health, and pitfalls in diagnosis and interpretation of experimental results. The book describes operational mechanisms of cancer at the levels of whole individual, organ, tissue, cell, molecular, and even atomic (quantum) scales of structural and physiological order. Evidence is assembled from all these levels of organization to show that cancer is a dynamically changing disorder and that it is an inherent and perpetual risk of multicellular composition. This provides pragmatic new biological and clinical perspectives on malignant neoplasia. The biological insight is that it is a consequence of progressing miscommunication within a cellular society. The clinical perspective is realistic but optimistic in reasoning that, although cancer can never be completely eradicated from human life, because it is a disorder of our intrinsic biological constitution, it can be controlled and ameliorated and even cured in a proportion of individuals. The text is profusely illustrated with over 300 macroscopic and microscopic pictures. It will stimulate curiosity and interest specialists, as well as beginners, in many scientific disciplines and provides copious references to the medical and scientific literature supporting its conclusions. Readers from fields as diverse as medicine, pathology, veterinary sciences, cell biology, molecular biology, developmental biology, and epidemiology will find the information the book contains thought-provoking, interesting, and useful. Additionally, specialists in occupational and environmental health and legal experts focusing on exposure to carcinogenic materials and pollution will find the contents valuable and informative.