Cancer Metastasis Through The Lymphovascular System
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Cancer Metastasis Through The Lymphovascular System
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Author : Stanley P. Leong
language : en
Publisher: Springer Nature
Release Date : 2022-06-24
Cancer Metastasis Through The Lymphovascular System written by Stanley P. Leong and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-24 with Medical categories.
This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions.
Cancer Metastasis Through The Lymphovascular System
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Author : S. David Nathanson
language : en
Publisher:
Release Date : 2022
Cancer Metastasis Through The Lymphovascular System written by S. David Nathanson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Cancer categories.
This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. .
Cancer Metastasis And The Lymphovascular System
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Author : Stanley P. L. Leong
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-05
Cancer Metastasis And The Lymphovascular System written by Stanley P. L. Leong and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-05 with Medical categories.
This book details the anatomy and physiology of the lymphovascular system as well as describes the mechanisms of metastasis. It provides readers with an understanding of immune responses of draining lymph nodes against cancer. Coverage also explains the rationale of adopting molecular therapeutics against growth factor receptors, apoptotic factors, signaling pathways and angiogenesis.
From Local Invasion To Metastatic Cancer
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Author : Stanley P. L. Leong
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-09
From Local Invasion To Metastatic Cancer written by Stanley P. L. Leong and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-09 with Medical categories.
In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.
Lymphatic Metastasis And Sentinel Lymphonodectomy
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Author : P.M. Schlag
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Lymphatic Metastasis And Sentinel Lymphonodectomy written by P.M. Schlag and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Metastases determine malignancy. The main attention so far has been focused upon organ metastases. The molecular mechanisms thereof, while far from being totally elucidated, are increasingly well understood. Modern diagnostic tools now enable detection and precise localization of small lesions. In contrast, our knowl edge and diagnostic capabilities regarding metastatic spread to the'lymphatic system are rather limited. However, there have re cently been a number of interesting advances. It is the aim of this volume to submit these developments to detailed analysis. The therapeutic relevance of enhanced sensitivity in detection of lymph node metastases has to be considered in the light of in creased morbidity versus eventual prognostic improvements by modification of therapy. An interesting concept which might im prove diagnostic accuracy while reducing operative morbidity is the "sentinel node" technique. Surgical standards are lacking, however, and many fundamental questions pertaining to precise lymphatic mapping remain unanswered. Whether the sentinel node concept is of general relevance or whether it is applicable in only a few organs remains to be determined. This book offers intensive discussion of the concept from methodological and tu mor biological viewpoints. World-renowned experts with long term involvement in related basic and clinical research provide the reader with a broad survey of actual knowledge together with a critical appraisal of recent and future developments. We sincerely hope this book succeeds in providing an outlook as a reference for all clinicians on future prospects and serving and researchers in this extremely important field.
Lymphatic System Metastasis
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Author : Leonard Weiss
language : en
Publisher:
Release Date : 1980
Lymphatic System Metastasis written by Leonard Weiss and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Lymphatic metastasis categories.
An Experimental Model For Lymphangiogenesis And Lymphatic Metastasis
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Author :
language : en
Publisher:
Release Date : 2002
An Experimental Model For Lymphangiogenesis And Lymphatic Metastasis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
For patients diagnosed with cancer, metastasis is the most critical prognostic factor. Even after surgical removal and systemic chemo- or radiotherapy of the primary tumor, it is often the metastases that cause morbidity. One avenue of tumor cell metastasis is the circulation, but some of the most common cancers metastasize through the lymphatic system, as evidenced by the location of the metastases in local and/or regional lymph nodes or as in-transit metastases. Nonetheless, our understanding of lymphatic metastasis lags far behind that of the hematogenous route. One major block in illuminating the mechanisms of lymphatic metastasis is the lack of a cohesive understanding of lymphatic biology, function, and neogenesis. It is still unclear how tumors gain access to the lymphatics; they may alter peripheral lymphatic vessels, induce peripheral lymphangiogenesis, or simply invade preexisting lymphatics. The lack of a cohesive understanding of lymphatic biology is the major hurdle in studying lymphatic metastasis. Systematic studies can only be realized with the development of model systems of normal and tumor lymphangiogenesis.
Selective Sentinel Lymphadenectomy For Human Solid Cancer
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Author : Stanley P. L. Leong
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-06-20
Selective Sentinel Lymphadenectomy For Human Solid Cancer written by Stanley P. L. Leong and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-20 with Medical categories.
First book to apply the concept of SSL to the majority of human cancers Revolutionary new concept that might significantly transform surgical cancer treatment Focuses on cancer metastasis and explores the biological frontier of micro metastasis Includes illustrations by experts in the field on how to successfully perform SSL
Mechanisms And Therapy For Cancer Metastasis To The Central Nervous System
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Author : Haotian Zhao
language : en
Publisher: Frontiers Media SA
Release Date : 2019-05-15
Mechanisms And Therapy For Cancer Metastasis To The Central Nervous System written by Haotian Zhao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-15 with categories.
The Lymphatic System And Cancer
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Author : John L. Meyer
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1994
The Lymphatic System And Cancer written by John L. Meyer and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Lymphatic metastasis - categories.
We are entering a new era of understanding the lymphatic system brought about by important insights from experimental investigations and clinical trials.