Method Of Lines Pde Analysis In Biomedical Science And Engineering
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Method Of Lines Pde Analysis In Biomedical Science And Engineering
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Author : William E. Schiesser
language : en
Publisher: John Wiley & Sons
Release Date : 2016-03-31
Method Of Lines Pde Analysis In Biomedical Science And Engineering written by William E. Schiesser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-31 with Mathematics categories.
Presents the methodology and applications of ODE and PDE models within biomedical science and engineering With an emphasis on the method of lines (MOL) for partial differential equation (PDE) numerical integration, Method of Lines PDE Analysis in Biomedical Science and Engineering demonstrates the use of numerical methods for the computer solution of PDEs as applied to biomedical science and engineering (BMSE). Written by a well-known researcher in the field, the book provides an introduction to basic numerical methods for initial/boundary value PDEs before moving on to specific BMSE applications of PDEs. Featuring a straightforward approach, the book’s chapters follow a consistent and comprehensive format. First, each chapter begins by presenting the model as an ordinary differential equation (ODE)/PDE system, including the initial and boundary conditions. Next, the programming of the model equations is introduced through a series of R routines that primarily implement MOL for PDEs. Subsequently, the resulting numerical and graphical solution is discussed and interpreted with respect to the model equations. Finally, each chapter concludes with a review of the numerical algorithm performance, general observations and results, and possible extensions of the model. Method of Lines PDE Analysis in Biomedical Science and Engineering also includes: Examples of MOL analysis of PDEs, including BMSE applications in wave front resolution in chromatography, VEGF angiogenesis, thermographic tumor location, blood-tissue transport, two fluid and membrane mass transfer, artificial liver support system, cross diffusion epidemiology, oncolytic virotherapy, tumor cell density in glioblastomas, and variable grids Discussions on the use of R software, which facilitates immediate solutions to differential equation problems without having to first learn the basic concepts of numerical analysis for PDEs and the programming of PDE algorithms A companion website that provides source code for the R routines Method of Lines PDE Analysis in Biomedical Science and Engineering is an introductory reference for researchers, scientists, clinicians, medical researchers, mathematicians, statisticians, chemical engineers, epidemiologists, and pharmacokineticists as well as anyone interested in clinical applications and the interpretation of experimental data with differential equation models. The book is also an ideal textbook for graduate-level courses in applied mathematics, BMSE, biology, biophysics, biochemistry, medicine, and engineering.
Method Of Lines Pde Analysis In Biomedical Science And Engineering
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Author : William E. Schiesser
language : en
Publisher: John Wiley & Sons
Release Date : 2016-04-13
Method Of Lines Pde Analysis In Biomedical Science And Engineering written by William E. Schiesser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-13 with Mathematics categories.
Presents the methodology and applications of ODE and PDE models within biomedical science and engineering With an emphasis on the method of lines (MOL) for partial differential equation (PDE) numerical integration, Method of Lines PDE Analysis in Biomedical Science and Engineering demonstrates the use of numerical methods for the computer solution of PDEs as applied to biomedical science and engineering (BMSE). Written by a well-known researcher in the field, the book provides an introduction to basic numerical methods for initial/boundary value PDEs before moving on to specific BMSE applications of PDEs. Featuring a straightforward approach, the book’s chapters follow a consistent and comprehensive format. First, each chapter begins by presenting the model as an ordinary differential equation (ODE)/PDE system, including the initial and boundary conditions. Next, the programming of the model equations is introduced through a series of R routines that primarily implement MOL for PDEs. Subsequently, the resulting numerical and graphical solution is discussed and interpreted with respect to the model equations. Finally, each chapter concludes with a review of the numerical algorithm performance, general observations and results, and possible extensions of the model. Method of Lines PDE Analysis in Biomedical Science and Engineering also includes: Examples of MOL analysis of PDEs, including BMSE applications in wave front resolution in chromatography, VEGF angiogenesis, thermographic tumor location, blood-tissue transport, two fluid and membrane mass transfer, artificial liver support system, cross diffusion epidemiology, oncolytic virotherapy, tumor cell density in glioblastomas, and variable grids Discussions on the use of R software, which facilitates immediate solutions to differential equation problems without having to first learn the basic concepts of numerical analysis for PDEs and the programming of PDE algorithms A companion website that provides source code for the R routines Method of Lines PDE Analysis in Biomedical Science and Engineering is an introductory reference for researchers, scientists, clinicians, medical researchers, mathematicians, statisticians, chemical engineers, epidemiologists, and pharmacokineticists as well as anyone interested in clinical applications and the interpretation of experimental data with differential equation models. The book is also an ideal textbook for graduate-level courses in applied mathematics, BMSE, biology, biophysics, biochemistry, medicine, and engineering.
Ode Pde Analysis Of Multiple Myeloma
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Author : William E. Schiesser
language : en
Publisher: CRC Press
Release Date : 2020-05-28
Ode Pde Analysis Of Multiple Myeloma written by William E. Schiesser and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-28 with Mathematics categories.
Multiple myeloma is a form of bone cancer. Specifically, it is a cancer of the plasma cells found in bone marrow (bone soft tissue). Normal plasma cells are an important part of the immune system. Mathematical models for multiple myeloma based on ordinary and partial differential equations (ODE/PDEs) are presented in this book, starting with a basic ODE model in Chapter 1, and concluding with a detailed ODE/PDE model in Chapter 4 that gives the spatiotemporal distribution of four dependent variable components in the bone marrow and peripheral blood: (1) protein produced by multiple myeloma cells, termed the M protein, (2) cytotoxic T lymphocytes (CTLs), (3) natural killer (NK) cells, and (4) regulatory T cells (Tregs). The computer-based implementation of the example models is presented through routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers using the R routines that are available through a download. The PDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences.
Nonlinear Higher Order Differential And Integral Coupled Systems Impulsive And Integral Equations On Bounded And Unbounded Domains
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Author : Feliz Manuel Minhos
language : en
Publisher: World Scientific
Release Date : 2022-04-11
Nonlinear Higher Order Differential And Integral Coupled Systems Impulsive And Integral Equations On Bounded And Unbounded Domains written by Feliz Manuel Minhos and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-11 with Mathematics categories.
Boundary value problems on bounded or unbounded intervals, involving two or more coupled systems of nonlinear differential and integral equations with full nonlinearities, are scarce in the literature. The present work by the authors desires to fill this gap. The systems covered here include differential and integral equations of Hammerstein-type with boundary constraints, on bounded or unbounded intervals. These are presented in several forms and conditions (three points, mixed, with functional dependence, homoclinic and heteroclinic, amongst others). This would be the first time that differential and integral coupled systems are studied systematically. The existence, and in some cases, the localization of the solutions are carried out in Banach space, following several types of arguments and approaches such as Schauder's fixed-point theorem or Guo-Krasnosel'ski? fixed-point theorem in cones, allied to Green's function or its estimates, lower and upper solutions, convenient truncatures, the Nagumo condition presented in different forms, the concept of equiconvergence, Carathéodory functions, and sequences. Moreover, the final part in the volume features some techniques on how to relate differential coupled systems to integral ones, which require less regularity. Parallel to the theoretical explanation of this work, there is a range of practical examples and applications involving real phenomena, focusing on physics, mechanics, biology, forestry, and dynamical systems, which researchers and students will find useful.
Time Delay Ode Pde Models
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Author : W.E. Schiesser
language : en
Publisher: CRC Press
Release Date : 2019-11-25
Time Delay Ode Pde Models written by W.E. Schiesser and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-25 with Mathematics categories.
Time delayed (lagged) variables are an inherent feature of biological/physiological systems. For example, infection from a disease may at first be asymptomatic, and only after a delay is the infection apparent so that treatment can begin.Thus, to adequately describe physiological systems, time delays are frequently required and must be included in the equations of mathematical models. The intent of this book is to present a methodology for the formulation and computer implementation of mathematical models based on time delay ordinary differential equations (DODEs) and partial differential equations (DPDEs). The DODE/DPDE methodology is presented through a series of example applications, particularly in biomedical science and engineering (BMSE). The computer-based implementation of the example models is explained with routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The DPDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences. The example applications can first be executed to confirm the reported solutions, then extended by variation of the parameters and the equation terms, and even the forumulation and use of alternative DODE/DPDE models. • Introduces time delay ordinary and partial differential equations (DODE/DPDEs) and their numerical computer-based integration (solution) • Illustrates the computer implementation of DODE/DPDE models with coding (programming) in R, a quality, open-source scientific programming system readily available from the Internet • Applies DODE/DPDE models to biological/physiological systems through a series of examples • Provides the R routines for all of the illustrative applications through a download link • Facilitates the use of the models with reasonable time and effort on modest computers
A Compendium Of Partial Differential Equation Models
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Author : William E. Schiesser
language : en
Publisher: Cambridge University Press
Release Date : 2009-03-16
A Compendium Of Partial Differential Equation Models written by William E. Schiesser and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-16 with Mathematics categories.
Mathematical modelling of physical and chemical systems is used extensively throughout science, engineering, and applied mathematics. To use mathematical models, one needs solutions to the model equations; this generally requires numerical methods. This book presents numerical methods and associated computer code in Matlab for the solution of a spectrum of models expressed as partial differential equations (PDEs). The authors focus on the method of lines (MOL), a well-established procedure for all major classes of PDEs, where the boundary value partial derivatives are approximated algebraically by finite differences. This reduces the PDEs to ordinary differential equations (ODEs) and makes the computer code easy to understand, implement, and modify. Also, the ODEs (via MOL) can be combined with any other ODEs that are part of the model (so that MOL naturally accommodates ODE/PDE models). This book uniquely includes a detailed line-by-line discussion of computer code related to the associated PDE model.
The Numerical Method Of Lines
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Author : William E. Schiesser
language : en
Publisher: Elsevier
Release Date : 2012-07-27
The Numerical Method Of Lines written by William E. Schiesser and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-27 with Mathematics categories.
This is the first book on the numerical method of lines, a relatively new method for solving partial differential equations. The Numerical Method of Lines is also the first book to accommodate all major classes of partial differential equations. This is essentially an applications book for computer scientists. The author will separately offer a disk of FORTRAN 77 programs with 250 specific applications, ranging from "Shuttle Launch Simulation" to "Temperature Control of a Nuclear Fuel Rod."
Partial Differential Equation Analysis In Biomedical Engineering
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Author : W. E. Schiesser
language : en
Publisher: Cambridge University Press
Release Date : 2013
Partial Differential Equation Analysis In Biomedical Engineering written by W. E. Schiesser and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Mathematics categories.
Gives graduate students and researchers an introductory overview of partial differential equation analysis of biomedical engineering systems through detailed examples.
Spline Collocation Methods For Partial Differential Equations
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Author : William E. Schiesser
language : en
Publisher: John Wiley & Sons
Release Date : 2017-05-22
Spline Collocation Methods For Partial Differential Equations written by William E. Schiesser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-22 with Mathematics categories.
A comprehensive approach to numerical partial differential equations Spline Collocation Methods for Partial Differential Equations combines the collocation analysis of partial differential equations (PDEs) with the method of lines (MOL) in order to simplify the solution process. Using a series of example applications, the author delineates the main features of the approach in detail, including an established mathematical framework. The book also clearly demonstrates that spline collocation can offer a comprehensive method for numerical integration of PDEs when it is used with the MOL in which spatial (boundary value) derivatives are approximated with splines, including the boundary conditions. R, an open-source scientific programming system, is used throughout for programming the PDEs and numerical algorithms, and each section of code is clearly explained. As a result, readers gain a complete picture of the model and its computer implementation without having to fill in the details of the numerical analysis, algorithms, or programming. The presentation is not heavily mathematical, and in place of theorems and proofs, detailed example applications are provided. Appropriate for scientists, engineers, and applied mathematicians, Spline Collocation Methods for Partial Differential Equations: Introduces numerical methods by first presenting basic examples followed by more complicated applications Employs R to illustrate accurate and efficient solutions of the PDE models Presents spline collocation as a comprehensive approach to the numerical integration of PDEs and an effective alternative to other, well established methods Discusses how to reproduce and extend the presented numerical solutions Identifies the use of selected algorithms, such as the solution of nonlinear equations and banded or sparse matrix processing Features a companion website that provides the related R routines Spline Collocation Methods for Partial Differential Equations is a valuable reference and/or self-study guide for academics, researchers, and practitioners in applied mathematics and engineering, as well as for advanced undergraduates and graduate-level students.
Partial Differential Equations And The Finite Element Method
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Author : Pavel Ŝolín
language : en
Publisher: John Wiley & Sons
Release Date : 2005-12-16
Partial Differential Equations And The Finite Element Method written by Pavel Ŝolín and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-16 with Mathematics categories.
A systematic introduction to partial differential equations and modern finite element methods for their efficient numerical solution Partial Differential Equations and the Finite Element Method provides a much-needed, clear, and systematic introduction to modern theory of partial differential equations (PDEs) and finite element methods (FEM). Both nodal and hierachic concepts of the FEM are examined. Reflecting the growing complexity and multiscale nature of current engineering and scientific problems, the author emphasizes higher-order finite element methods such as the spectral or hp-FEM. A solid introduction to the theory of PDEs and FEM contained in Chapters 1-4 serves as the core and foundation of the publication. Chapter 5 is devoted to modern higher-order methods for the numerical solution of ordinary differential equations (ODEs) that arise in the semidiscretization of time-dependent PDEs by the Method of Lines (MOL). Chapter 6 discusses fourth-order PDEs rooted in the bending of elastic beams and plates and approximates their solution by means of higher-order Hermite and Argyris elements. Finally, Chapter 7 introduces the reader to various PDEs governing computational electromagnetics and describes their finite element approximation, including modern higher-order edge elements for Maxwell's equations. The understanding of many theoretical and practical aspects of both PDEs and FEM requires a solid knowledge of linear algebra and elementary functional analysis, such as functions and linear operators in the Lebesgue, Hilbert, and Sobolev spaces. These topics are discussed with the help of many illustrative examples in Appendix A, which is provided as a service for those readers who need to gain the necessary background or require a refresher tutorial. Appendix B presents several finite element computations rooted in practical engineering problems and demonstrates the benefits of using higher-order FEM. Numerous finite element algorithms are written out in detail alongside implementation discussions. Exercises, including many that involve programming the FEM, are designed to assist the reader in solving typical problems in engineering and science. Specifically designed as a coursebook, this student-tested publication is geared to upper-level undergraduates and graduate students in all disciplines of computational engineeringand science. It is also a practical problem-solving reference for researchers, engineers, and physicists.