Method Of Lines Pde Analysis In Biomedical Science And Engineering
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Method Of Lines Pde Analysis In Biomedical Science And Engineering
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Author : William E. Schiesser
language : en
Publisher: John Wiley & Sons
Release Date : 2016-03-31
Method Of Lines Pde Analysis In Biomedical Science And Engineering written by William E. Schiesser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-31 with Mathematics categories.
Presents the methodology and applications of ODE and PDE models within biomedical science and engineering With an emphasis on the method of lines (MOL) for partial differential equation (PDE) numerical integration, Method of Lines PDE Analysis in Biomedical Science and Engineering demonstrates the use of numerical methods for the computer solution of PDEs as applied to biomedical science and engineering (BMSE). Written by a well-known researcher in the field, the book provides an introduction to basic numerical methods for initial/boundary value PDEs before moving on to specific BMSE applications of PDEs. Featuring a straightforward approach, the book’s chapters follow a consistent and comprehensive format. First, each chapter begins by presenting the model as an ordinary differential equation (ODE)/PDE system, including the initial and boundary conditions. Next, the programming of the model equations is introduced through a series of R routines that primarily implement MOL for PDEs. Subsequently, the resulting numerical and graphical solution is discussed and interpreted with respect to the model equations. Finally, each chapter concludes with a review of the numerical algorithm performance, general observations and results, and possible extensions of the model. Method of Lines PDE Analysis in Biomedical Science and Engineering also includes: Examples of MOL analysis of PDEs, including BMSE applications in wave front resolution in chromatography, VEGF angiogenesis, thermographic tumor location, blood-tissue transport, two fluid and membrane mass transfer, artificial liver support system, cross diffusion epidemiology, oncolytic virotherapy, tumor cell density in glioblastomas, and variable grids Discussions on the use of R software, which facilitates immediate solutions to differential equation problems without having to first learn the basic concepts of numerical analysis for PDEs and the programming of PDE algorithms A companion website that provides source code for the R routines Method of Lines PDE Analysis in Biomedical Science and Engineering is an introductory reference for researchers, scientists, clinicians, medical researchers, mathematicians, statisticians, chemical engineers, epidemiologists, and pharmacokineticists as well as anyone interested in clinical applications and the interpretation of experimental data with differential equation models. The book is also an ideal textbook for graduate-level courses in applied mathematics, BMSE, biology, biophysics, biochemistry, medicine, and engineering.
Method Of Lines Pde Analysis In Biomedical Science And Engineering
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Author : William E. Schiesser
language : en
Publisher: John Wiley & Sons
Release Date : 2016-04-18
Method Of Lines Pde Analysis In Biomedical Science And Engineering written by William E. Schiesser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-18 with Mathematics categories.
Presents the methodology and applications of ODE and PDE models within biomedical science and engineering With an emphasis on the method of lines (MOL) for partial differential equation (PDE) numerical integration, Method of Lines PDE Analysis in Biomedical Science and Engineering demonstrates the use of numerical methods for the computer solution of PDEs as applied to biomedical science and engineering (BMSE). Written by a well-known researcher in the field, the book provides an introduction to basic numerical methods for initial/boundary value PDEs before moving on to specific BMSE applications of PDEs. Featuring a straightforward approach, the book’s chapters follow a consistent and comprehensive format. First, each chapter begins by presenting the model as an ordinary differential equation (ODE)/PDE system, including the initial and boundary conditions. Next, the programming of the model equations is introduced through a series of R routines that primarily implement MOL for PDEs. Subsequently, the resulting numerical and graphical solution is discussed and interpreted with respect to the model equations. Finally, each chapter concludes with a review of the numerical algorithm performance, general observations and results, and possible extensions of the model. Method of Lines PDE Analysis in Biomedical Science and Engineering also includes: Examples of MOL analysis of PDEs, including BMSE applications in wave front resolution in chromatography, VEGF angiogenesis, thermographic tumor location, blood-tissue transport, two fluid and membrane mass transfer, artificial liver support system, cross diffusion epidemiology, oncolytic virotherapy, tumor cell density in glioblastomas, and variable grids Discussions on the use of R software, which facilitates immediate solutions to differential equation problems without having to first learn the basic concepts of numerical analysis for PDEs and the programming of PDE algorithms A companion website that provides source code for the R routines Method of Lines PDE Analysis in Biomedical Science and Engineering is an introductory reference for researchers, scientists, clinicians, medical researchers, mathematicians, statisticians, chemical engineers, epidemiologists, and pharmacokineticists as well as anyone interested in clinical applications and the interpretation of experimental data with differential equation models. The book is also an ideal textbook for graduate-level courses in applied mathematics, BMSE, biology, biophysics, biochemistry, medicine, and engineering.
Time Delay Ode Pde Models
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Author : W.E. Schiesser
language : en
Publisher: CRC Press
Release Date : 2019-11-25
Time Delay Ode Pde Models written by W.E. Schiesser and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-25 with Medical categories.
Time delayed (lagged) variables are an inherent feature of biological/physiological systems. For example, infection from a disease may at first be asymptomatic, and only after a delay is the infection apparent so that treatment can begin. Thus, to adequately describe physiological systems, time delays are frequently required and must be included in the equations of mathematical models. The intent of this book is to present a methodology for the formulation and computer implementation of mathematical models based on time delay ordinary differential equations (DODEs) and partial differential equations (DPDEs). The DODE/DPDE methodology is presented through a series of example applications, particularly in biomedical science and engineering (BMSE). The computer-based implementation of the example models is explained with routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, for example, no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The DPDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences. The example applications can first be executed to confirm the reported solutions, then extended by variation of the parameters and the equation terms, and even the formulation and use of alternative DODE/DPDE models.
Differential Equation Analysis In Biomedical Science And Engineering
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Author : William E. Schiesser
language : en
Publisher: John Wiley & Sons
Release Date : 2014-03-31
Differential Equation Analysis In Biomedical Science And Engineering written by William E. Schiesser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-31 with Mathematics categories.
Features a solid foundation of mathematical and computational tools to formulate and solve real-world PDE problems across various fields With a step-by-step approach to solving partial differential equations (PDEs), Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R successfully applies computational techniques for solving real-world PDE problems that are found in a variety of fields, including chemistry, physics, biology, and physiology. The book provides readers with the necessary knowledge to reproduce and extend the computed numerical solutions and is a valuable resource for dealing with a broad class of linear and nonlinear partial differential equations. The author’s primary focus is on models expressed as systems of PDEs, which generally result from including spatial effects so that the PDE dependent variables are functions of both space and time, unlike ordinary differential equation (ODE) systems that pertain to time only. As such, the book emphasizes details of the numerical algorithms and how the solutions were computed. Featuring computer-based mathematical models for solving real-world problems in the biological and biomedical sciences and engineering, the book also includes: R routines to facilitate the immediate use of computation for solving differential equation problems without having to first learn the basic concepts of numerical analysis and programming for PDEs Models as systems of PDEs and associated initial and boundary conditions with explanations of the associated chemistry, physics, biology, and physiology Numerical solutions of the presented model equations with a discussion of the important features of the solutions Aspects of general PDE computation through various biomedical science and engineering applications Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R is an excellent reference for researchers, scientists, clinicians, medical researchers, engineers, statisticians, epidemiologists, and pharmacokineticists who are interested in both clinical applications and interpretation of experimental data with mathematical models in order to efficiently solve the associated differential equations. The book is also useful as a textbook for graduate-level courses in mathematics, biomedical science and engineering, biology, biophysics, biochemistry, medicine, and engineering.
Spatiotemporal Modeling Of Influenza
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Author : William E. Schiesser
language : en
Publisher: Springer Nature
Release Date : 2022-05-31
Spatiotemporal Modeling Of Influenza written by William E. Schiesser and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-31 with Technology & Engineering categories.
This book has a two-fold purpose: (1) An introduction to the computer-based modeling of influenza, a continuing major worldwide communicable disease. (2) The use of (1) as an illustration of a methodology for the computer-based modeling of communicable diseases. For the purposes of (1) and (2), a basic influenza model is formulated as a system of partial differential equations (PDEs) that define the spatiotemporal evolution of four populations: susceptibles, untreated and treated infecteds, and recovereds. The requirements of a well-posed PDE model are considered, including the initial and boundary conditions. The terms of the PDEs are explained. The computer implementation of the model is illustrated with a detailed line-by-line explanation of a system of routines in R (a quality, open-source scientific computing system that is readily available from the Internet). The R routines demonstrate the straightforward numerical solution of a system of nonlinear PDEs by the method of lines (MOL), an established general algorithm for PDEs. The presentation of the PDE modeling methodology is introductory with a minumum of formal mathematics (no theorems and proofs), and with emphasis on example applications. The intent of the book is to assist in the initial understanding and use of PDE mathematical modeling of communicable diseases, and the explanation and interpretation of the computed model solutions, as illustrated with the influenza model.
Ode Pde Analysis Of Multiple Myeloma
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Author : William E. Schiesser
language : en
Publisher: CRC Press
Release Date : 2020-05-28
Ode Pde Analysis Of Multiple Myeloma written by William E. Schiesser and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-28 with Mathematics categories.
Multiple myeloma is a form of bone cancer. Specifically, it is a cancer of the plasma cells found in bone marrow (bone soft tissue). Normal plasma cells are an important part of the immune system. Mathematical models for multiple myeloma based on ordinary and partial differential equations (ODE/PDEs) are presented in this book, starting with a basic ODE model in Chapter 1, and concluding with a detailed ODE/PDE model in Chapter 4 that gives the spatiotemporal distribution of four dependent variable components in the bone marrow and peripheral blood: (1) protein produced by multiple myeloma cells, termed the M protein, (2) cytotoxic T lymphocytes (CTLs), (3) natural killer (NK) cells, and (4) regulatory T cells (Tregs). The computer-based implementation of the example models is presented through routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers using the R routines that are available through a download. The PDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences.
Numerical Modeling Of Covid 19 Neurological Effects
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Author : William Schiesser
language : en
Publisher: CRC Press
Release Date : 2021-12-26
Numerical Modeling Of Covid 19 Neurological Effects written by William Schiesser and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-26 with Mathematics categories.
Covid-19 is primarily a respiratory disease which results in impaired oxygenation of blood. The O2-deficient blood then moves through the body, and for the study in this book, the focus is on the blood flowing to the brain. The dynamics of blood flow along the brain capillaries and tissue is modeled as systems of ordinary and partial differential equations (ODE/PDEs). The ODE/PDE methodology is presented through a series of examples, 1. A basic one PDE model for O2 concentration in the brain capillary blood. 2. A two PDE model for O2 concentration in the brain capillary blood and in the brain tissue, with O2 transport across the blood brain barrier (BBB). 3. The two model extended to three PDEs to include the brain functional neuron cell density. Cognitive impairment could result from reduced neuron cell density in time and space (in the brain) that follows from lowered O2 concentration (hypoxia). The computer-based implementation of the example models is presented through routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The PDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences. The routines are available from a download link so that the example models can be executed without having to first study numerical methods and computer coding. The routines can then be applied to variations and extensions of the blood/brain hypoxia models, such as changes in the ODE/PDE parameters (constants) and form of the model equations.
Spline Collocation Methods For Partial Differential Equations
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Author : William E. Schiesser
language : en
Publisher: John Wiley & Sons
Release Date : 2017-04-24
Spline Collocation Methods For Partial Differential Equations written by William E. Schiesser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-24 with Mathematics categories.
A comprehensive approach to numerical partial differential equations Spline Collocation Methods for Partial Differential Equations combines the collocation analysis of partial differential equations (PDEs) with the method of lines (MOL) in order to simplify the solution process. Using a series of example applications, the author delineates the main features of the approach in detail, including an established mathematical framework. The book also clearly demonstrates that spline collocation can offer a comprehensive method for numerical integration of PDEs when it is used with the MOL in which spatial (boundary value) derivatives are approximated with splines, including the boundary conditions. R, an open-source scientific programming system, is used throughout for programming the PDEs and numerical algorithms, and each section of code is clearly explained. As a result, readers gain a complete picture of the model and its computer implementation without having to fill in the details of the numerical analysis, algorithms, or programming. The presentation is not heavily mathematical, and in place of theorems and proofs, detailed example applications are provided. Appropriate for scientists, engineers, and applied mathematicians, Spline Collocation Methods for Partial Differential Equations: Introduces numerical methods by first presenting basic examples followed by more complicated applications Employs R to illustrate accurate and efficient solutions of the PDE models Presents spline collocation as a comprehensive approach to the numerical integration of PDEs and an effective alternative to other, well established methods Discusses how to reproduce and extend the presented numerical solutions Identifies the use of selected algorithms, such as the solution of nonlinear equations and banded or sparse matrix processing Features a companion website that provides the related R routines Spline Collocation Methods for Partial Differential Equations is a valuable reference and/or self-study guide for academics, researchers, and practitioners in applied mathematics and engineering, as well as for advanced undergraduates and graduate-level students.
Nonlinear Higher Order Differential And Integral Coupled Systems Impulsive And Integral Equations On Bounded And Unbounded Domains
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Author : Feliz Manuel Minhos
language : en
Publisher: World Scientific
Release Date : 2022-04-11
Nonlinear Higher Order Differential And Integral Coupled Systems Impulsive And Integral Equations On Bounded And Unbounded Domains written by Feliz Manuel Minhos and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-11 with Mathematics categories.
Boundary value problems on bounded or unbounded intervals, involving two or more coupled systems of nonlinear differential and integral equations with full nonlinearities, are scarce in the literature. The present work by the authors desires to fill this gap. The systems covered here include differential and integral equations of Hammerstein-type with boundary constraints, on bounded or unbounded intervals. These are presented in several forms and conditions (three points, mixed, with functional dependence, homoclinic and heteroclinic, amongst others). This would be the first time that differential and integral coupled systems are studied systematically. The existence, and in some cases, the localization of the solutions are carried out in Banach space, following several types of arguments and approaches such as Schauder's fixed-point theorem or Guo-Krasnosel'ski? fixed-point theorem in cones, allied to Green's function or its estimates, lower and upper solutions, convenient truncatures, the Nagumo condition presented in different forms, the concept of equiconvergence, Carathéodory functions, and sequences. Moreover, the final part in the volume features some techniques on how to relate differential coupled systems to integral ones, which require less regularity. Parallel to the theoretical explanation of this work, there is a range of practical examples and applications involving real phenomena, focusing on physics, mechanics, biology, forestry, and dynamical systems, which researchers and students will find useful.
Partial Differential Equation Analysis In Biomedical Engineering
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Author : W. E. Schiesser
language : en
Publisher: Cambridge University Press
Release Date : 2013
Partial Differential Equation Analysis In Biomedical Engineering written by W. E. Schiesser and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Mathematics categories.
Gives graduate students and researchers an introductory overview of partial differential equation analysis of biomedical engineering systems through detailed examples.