Methods For Genetic Risk Assessment
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Methods For Genetic Risk Assessment
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Author : David Brusick
language : en
Publisher: CRC Press
Release Date : 1994-01-11
Methods For Genetic Risk Assessment written by David Brusick and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-11 with Science categories.
Genetic disease contributes to a major portion of our health care costs. While most of the human genetic burden is transmitted from generation to generation, environmental chemicals capable of reacting with germ cell DNA could produce new mutations, resulting in an even greater genetic liability for the next generation. The potential impact of environmental mutagens on the health and viability of other living things is important to consider as well. Methods for Genetic Risk Assessment features contributions from international experts to provide a comprehensive review of the current status of genetic risk assessment. You'll learn about various methods and strategies for when and how to conduct genetic risk assessments on human populations. You will also learn about the potential effects of environmental genotoxins on nonhuman organisms. Topics considered include:
New Trends In Genetic Risk Assessment
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Author : G. Jolles
language : en
Publisher: Academic Press
Release Date : 2013-10-22
New Trends In Genetic Risk Assessment written by G. Jolles and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Social Science categories.
New Trends in Genetic Risk Assessment is based on the Fifth International Round Table of the Rhône-Poulenc Santé Foundation, held in Nice 1987. The conference was an attempt to review the latest theories and mechanisms stipulated for the various aspects of genotoxicity; it was above all an open forum to discuss the new trends, the new tests, and the new battery of tests for assessing the genetic risk of chemicals and especially drugs. This volume is actually not a proceedings of the meeting but a monograph specially edited to report the reviews which were presented and the discussions which took place; it was designed to provide a better understanding of the knowledge obtained in the most recent years and to help in the practical choice of approaches or tests for the prediction of the various forms of genotoxicity. The main subjects of this review concern molecular analysis of mutagenesis, detection of DNA damage, gene mutation, clastogenesis, aneuploidy, and germ cells. Each theme is preceded by a short overview summarizing the state of the art and the contributions of each author. Finally, special attention was given to the personal views of some leading toxicologists as to the battery of tests presently available or recommended.
Assessing Genetic Risks
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 1994-01-01
Assessing Genetic Risks written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-01 with Medical categories.
Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.
Methods For Risk Assessment Of Transgenic Plants
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Author : Klaus Ammann
language : en
Publisher: Springer
Release Date : 2012-12-06
Methods For Risk Assessment Of Transgenic Plants written by Klaus Ammann and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
For centuries, TK has been used almost exclusively by its creators, that is, indigenous and local communities. Access to, use of and handing down of TK has been regulated by local laws, customs and tmditions. Some TK has been freely accessible by all members of an indigenous or local community and has been freely exchanged with other communities; other TK has only been known to particular individuals within these communities such as shamans, and has been handed down only to particular individuals of thc next generation. Over many generations, indigenous and local communities have accumulated a great deal of TK which has generally been adapted, developed and improved by the generations that followed. For a long time, Western anthropologists and other scientists have generally been able to freely access TK and have documented it in their works. Still, this TK was only seldom used outside the indigenous and local communities that created it. More recently, however, Western scientists have become aware that TK is neither outdated nor valueless knowledge, but, instead, 1 can be useful to solve some of the problems facing today's world. Modem science, for example, has shown an increased interest in some fornls ofTK as knowledge that can be used in 4 research and development (R&D) activities and be integrated in modem innovations. This holds especially true for TK regarding genetic resources, which has been integrated in modem 6 phannaceuticals,s agro-chemicals and seed.
Genetic Toxicology And Cancer Risk Assessment
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Author : Wai Nang Choy
language : en
Publisher: CRC Press
Release Date : 2001-08-31
Genetic Toxicology And Cancer Risk Assessment written by Wai Nang Choy and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-08-31 with Medical categories.
Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
An Evidence Framework For Genetic Testing
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-04-21
An Evidence Framework For Genetic Testing written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-21 with Medical categories.
Advances in genetics and genomics are transforming medical practice, resulting in a dramatic growth of genetic testing in the health care system. The rapid development of new technologies, however, has also brought challenges, including the need for rigorous evaluation of the validity and utility of genetic tests, questions regarding the best ways to incorporate them into medical practice, and how to weigh their cost against potential short- and long-term benefits. As the availability of genetic tests increases so do concerns about the achievement of meaningful improvements in clinical outcomes, costs of testing, and the potential for accentuating medical care inequality. Given the rapid pace in the development of genetic tests and new testing technologies, An Evidence Framework for Genetic Testing seeks to advance the development of an adequate evidence base for genetic tests to improve patient care and treatment. Additionally, this report recommends a framework for decision-making regarding the use of genetic tests in clinical care.
Methods For Risk Assessment I Of Transgenic Plants
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Author : Gösta Kjellsson
language : en
Publisher: Springer Science & Business Media
Release Date : 1994
Methods For Risk Assessment I Of Transgenic Plants written by Gösta Kjellsson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Science categories.
The present book is a compilation of current test methods useful in risk assessment of transgenic plants. It is intended to aid the environmental researcher in finding and comparing relevant methods quickly and easily. It may also be used as a general reference work for field-ecologists, laboratory- biologists and others working in plant population biology and genetics. The major processes affecting the fate of plants are covered with emphasis on invasion, competition and establishment, e.g., seed dispersal, density-dependent competition, and plant growth. Ecosystem effects and genetic structure are also covered. For each process a number of relevant test methods have been selected; in total, 84 methods for field, greenhouse or laboratory research are included, employing 51 key processwords. Each method is described and evaluated briefly and succinctly, and there are comments on assumptions, restrictions, advantages, and applications. An extensive bibliography provides entry into the scientific background, and cross references make it possible quickly to find all relevant sources. Methods to study pollination and gene transfer will be considered in a future volume.
Methods For Risk Assessment Of Transgenic Plants
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Author : Gösta Kjellsson
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
Methods For Risk Assessment Of Transgenic Plants written by Gösta Kjellsson and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The present book is a compilation of current test methods useful in risk assessment of transgenic plants. It is intended to aid the environmental researcher in finding and comparing relevant methods quickly and easily. It may also be used as a general reference work for field-ecologists, laboratory- biologists and others working in plant population biology and genetics. The major processes affecting the fate of plants are covered with emphasis on invasion, competition and establishment, e.g., seed dispersal, density-dependent competition, and plant growth. Ecosystem effects and genetic structure are also covered. For each process a number of relevant test methods have been selected; in total, 84 methods for field, greenhouse or laboratory research are included, employing 51 key processwords. Each method is described and evaluated briefly and succinctly, and there are comments on assumptions, restrictions, advantages, and applications. An extensive bibliography provides entry into the scientific background, and cross references make it possible quickly to find all relevant sources. Methods to study pollination and gene transfer will be considered in a future volume.
Methods For Risk Assessment Of Transgenic Plants
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Author : Klaus Ammann
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-06-20
Methods For Risk Assessment Of Transgenic Plants written by Klaus Ammann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-20 with Medical categories.
For centuries, TK has been used almost exclusively by its creators, that is, indigenous and local communities. Access to, use of and handing down of TK has been regulated by local laws, customs and tmditions. Some TK has been freely accessible by all members of an indigenous or local community and has been freely exchanged with other communities; other TK has only been known to particular individuals within these communities such as shamans, and has been handed down only to particular individuals of thc next generation. Over many generations, indigenous and local communities have accumulated a great deal of TK which has generally been adapted, developed and improved by the generations that followed. For a long time, Western anthropologists and other scientists have generally been able to freely access TK and have documented it in their works. Still, this TK was only seldom used outside the indigenous and local communities that created it. More recently, however, Western scientists have become aware that TK is neither outdated nor valueless knowledge, but, instead, 1 can be useful to solve some of the problems facing today's world. Modem science, for example, has shown an increased interest in some fornls ofTK as knowledge that can be used in 4 research and development (R&D) activities and be integrated in modem innovations. This holds especially true for TK regarding genetic resources, which has been integrated in modem 6 phannaceuticals,s agro-chemicals and seed.
Methods For Risk Assessment Of Transgenic Plants
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FREE 30 Days
Author : Gösta Kjellsson
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
Methods For Risk Assessment Of Transgenic Plants written by Gösta Kjellsson and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The present work is a continuation of the work initiated in Autumn 1991, which resulted in the book, published by Birkhauser Verlag in 1994, entitled: Methods for Risk Assessment of Transgenic Plants. I. Competition, Establishment and Ecosystem Effects. Already when the work on volume 1 started, it was obvious to the authors, that not only the physical establishment of a transgenic plant outside the cultivated area was important for risk assessment, but also the possible gene-transfer from transgenic plants to other plants had to be considered. It was then decided to write a second volume on test methods, as a complement to the first, covering the main topics: Pollination, gene-transfer and population impacts. The main user groups for this volume are scientists and students working with plant population genetics and risk assessment and administrators with responsibility for legislation of transgenic plants. In order to cover such a broad range of topics, specialist knowledge was required. Therefore, colleagues in Denmark and Switzerland, working in these fields in relation to the concerns of using transgenic plants, were asked to participate. The result was a Danish-Swiss cooperation. A list of contributors to the book and their addresses is shown on p. VII. Financial support, which made the work possible, was given by: The National Environmental Research Institute, Denmark, the Federal Office of Environment, Forest and Landscape, Switzerland, the National Forest and Nature Agency, Denmark, the Danish Environmental Protection Agency and the European Commission, DC XI.