Microcirculation In Cancer Metastasis
DOWNLOAD
Download Microcirculation In Cancer Metastasis PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Microcirculation In Cancer Metastasis book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Microcirculation In Cancer Metastasis
DOWNLOAD
Author : F. William Orr
language : en
Publisher: CRC Press
Release Date : 1991-07-25
Microcirculation In Cancer Metastasis written by F. William Orr and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-07-25 with Medical categories.
Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process. This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.
Growth Microcirculation And Survival In Cancer Metastasis
DOWNLOAD
Author : Hemanth J. Varghese
language : en
Publisher:
Release Date : 2004
Growth Microcirculation And Survival In Cancer Metastasis written by Hemanth J. Varghese and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Tumor Angiogenesis And Microcirculation
DOWNLOAD
Author : Emile E. Voest
language : en
Publisher: CRC Press
Release Date : 2001-03-30
Tumor Angiogenesis And Microcirculation written by Emile E. Voest and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-03-30 with Medical categories.
Compiling the latest developments in anticancer therapies based on the connection between tumor and capillary growth, Tumor Angiogenesis and Microcirculation presents a comprehensive overview of diverse aspects of angiogenesis-related cancer research. Highlights the role angiogenesis and its inhibitors play in the growth, metastasis, and dormancy of tumors! Facilitating the progress of clinical practice with insights from methodological and scientific results, Tumor Angiogenesis and Microcirculation summarizes biological principles of angiogenesis and microcirculation, from endothelial cells and pericytes, and extracellular matrix regulation to matrix metalloproteinases (MMPs) and plasmin and plasmin inhibitors examines proangiogenic factors such as vascular endothelial (VEGF) and basic fibroblast (bFGF) growth factors, tie receptors, and cytokines outlines methods for discovering angiogenesis stimulators and inhibitor peptides, particularly the clinical development of thrombospondin, angiostatin, endostatin, and MMP inhibitors reveals the link between oncogenes and neoplastic angiogenesis and its regulation by the organ microenvironment investigates tumor vascularity in relation to tumor growth and the spread of cancer details promising future applications, including perspectives in vascular cancer therapy and more! Combining the resources of 60 recognized experts and nearly 3000 pertinent literature references, drawings, photographs, and x-rays, Tumor Angiogenesis and Microcirculation profits oncologists, pathologists, hematologists, and radiation and hemato-oncologists; surgeons and internists; cardiologists; immunologists; cell, molecular, and developmental biologists; rheumatologists; ophthalmologists; dermatologists; and medical school students in these disciplines.
Morphofunctional Aspects Of Tumor Microcirculation
DOWNLOAD
Author : Domenico Ribatti
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-28
Morphofunctional Aspects Of Tumor Microcirculation written by Domenico Ribatti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-28 with Medical categories.
Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.
Tumor Angiogenesis
DOWNLOAD
Author : Dieter Marmé
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-05
Tumor Angiogenesis written by Dieter Marmé and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-05 with Medical categories.
Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.
Blood Perfusion And Microenvironment Of Human Tumors
DOWNLOAD
Author : Michael Molls
language : en
Publisher:
Release Date : 1998
Blood Perfusion And Microenvironment Of Human Tumors written by Michael Molls and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
This book summarizes current knowledge on blood perfusion and the microenvironment of human tumors, enabling the reader to gain a deeper insight into the physiological components of malignant tumors. Among a range of topics, detailed consideration is given to circulatory parameters, including blood and nutrient supply, transvascular and interstitial transport, and oxygenation, as well as to bioenergetic status and the influence of pH on the responsiveness of malignant tumors to nonsurgical treatments such as radiotherapy and chemotherapy. For the clinician, it will be of special interest to read about the various invasive and noninvasive methods (including MR and PET) that allow the tumor physiology and microenvironment of an individual patient to be characterized.
Early Steps In Cancer Metastasis New Concepts From In Vivo Videomicroscopy
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 1997
Early Steps In Cancer Metastasis New Concepts From In Vivo Videomicroscopy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Clinically Applied Microcirculation Research
DOWNLOAD
Author : John Barker
language : en
Publisher: Routledge
Release Date : 2019-06-04
Clinically Applied Microcirculation Research written by John Barker and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Education categories.
First published in 1995: Clinically Applied Microcirculation Research combines state-of-the-art microcirculation technology with present and potential applications in clinical medicine. This comprehensive guide unites the expertise of clinicians and basic researchers from around the world. Many of the chapters are authored by scientist/physician teams. The book provides a broad overview of how microcirculation is involved in clinical research. This is also a valuable reference source for both the history of and latest developments in microcirculation research.
Molecular Cellular And Tissue Engineering Of The Vascular System
DOWNLOAD
Author : Bingmei M. Fu
language : en
Publisher: Springer
Release Date : 2018-10-12
Molecular Cellular And Tissue Engineering Of The Vascular System written by Bingmei M. Fu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-12 with Science categories.
This book introduces the latest research in molecular, cellular, and tissue engineering of the vascular system. Topics covered include the roles of endothelial surface glycocalyx as a mechano-sensor and transducer for blood flow, a barrier to water and solute transport across the vascular wall and to the interaction between circulating cells and the vessel wall, the roles of nuclear envelope proteins and nuclear lamina in regulating vascular functions under blood flow-induced forces, and the roles of smooth muscle cells and extracellular components in arterial vasoconstriction. Other topics covered include non-surgical vascular interventions for coronary artery diseases, genesis and mechanisms of atherosclerotic plaque microcalcifications and human abdominal aortic aneurysms, experiments and modelling for red blood cell and tumor cell movement in microcirculation, transport across the blood-brain barrier and its role in Alzheimer’s disease, mathematical models for cell survival after hyperthermia, application of hypothermia in enhancing treatment for brain and spinal cord injuries, and damage of eardrums due to blast waves. This is an ideal book for biomedical engineers and researchers, medical researchers, and students in biomedical engineering and medical sciences.
Heparanase
DOWNLOAD
Author : Israel Vlodavsky
language : en
Publisher: Springer Nature
Release Date : 2020-04-09
Heparanase written by Israel Vlodavsky and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-09 with Medical categories.
Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.