Microfluidics And Multi Organs On Chip
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Microfluidics And Multi Organs On Chip
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Author : P. V. Mohanan
language : en
Publisher: Springer Nature
Release Date : 2022-07-11
Microfluidics And Multi Organs On Chip written by P. V. Mohanan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-11 with Medical categories.
This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.
Organs On Chips
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Author : Yu-suke Torisawa
language : en
Publisher: MDPI
Release Date : 2020-05-27
Organs On Chips written by Yu-suke Torisawa and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-27 with Technology & Engineering categories.
Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices. Since the physiological microenvironments in living systems are mostly microfluidic in nature, the use of microfluidic devices facilitates engineering cellular microenvironments; the microfluidic devices allow for control of local chemical gradients and dynamic mechanical forces, which play important roles in cellular viability and function. The organ-on-chip microdevices have great potential to promote drug discovery and development, to model human physiology and disease, and to replace animal models for efficacy and toxicity testing. Recently, induced pluripotent stem (iPS) cells have been leveraged to develop organs-on-chips, which enable various types of organ models and disease models not possible with primary cells and cell lines. This Special Issue seeks to showcase research papers, short communications, and review articles that focus on: (1) microdevices to mimic or control cellular microenvironment; (2) microdevices to evaluate interactions between different organ models; (3) microdevices to maintain iPS cells or iPSC-derived cells; and (4) sensors and techniques to evaluate drug efficacy or toxicity.
Biofabrication
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Author : Gulden Camci-Unal
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-03-18
Biofabrication written by Gulden Camci-Unal and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-18 with Medical categories.
Microscale hydrogels are potentially useful materials for controlling cellular behavior to mimic native microenvironments for tissue engineering applications. In this chapter, various fabrication techniques to generate microscale hydrogels and their applications in tissue engineering have been outlined. In addition, we provide examples of microscale hydrogels with different physical and chemical properties for generation of tissue constructs. Finally, we discuss potential future directions in fabrication of hydrogels to address challenges in tissue engineering. It is expected that these techniques will enable engineering of three-dimensional (3D) structures with controlled features for the formation of functional tissues and organs.
Microfluidics And Lab On A Chip
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Author : Andreas Manz
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-09-24
Microfluidics And Lab On A Chip written by Andreas Manz and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-24 with Science categories.
Responding to the need for an affordable, easy-to-read textbook that introduces microfluidics to undergraduate and postgraduate students, this concise book will provide a broad overview of the important theoretical and practical aspects of microfluidics and lab-on-a-chip, as well as its applications.
Lab On A Chip Fabrication And Application
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Author : Margarita Stoytcheva
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-06-29
Lab On A Chip Fabrication And Application written by Margarita Stoytcheva and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-29 with Science categories.
The necessity of on-site, fast, sensitive, and cheap complex laboratory analysis, associated with the advances in the microfabrication technologies and the microfluidics, made it possible for the creation of the innovative device lab-on-a-chip (LOC), by which we would be able to scale a single or multiple laboratory processes down to a chip format. The present book is dedicated to the LOC devices from two points of view: LOC fabrication and LOC application.
Guide To Research Techniques In Neuroscience
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Author : Matt Carter
language : en
Publisher: Academic Press
Release Date : 2022-03-26
Guide To Research Techniques In Neuroscience written by Matt Carter and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-26 with Medical categories.
Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. - Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods - Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more - Clear, straightforward explanations of each technique for anyone new to the field - A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture - Detailed recommendations on where to find protocols and other resources for specific techniques - "Walk-through" boxes that guide readers through experiments step-by-step
Biomedical Applications Of Microfluidic Devices
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Author : Michael R. Hamblin
language : en
Publisher: Academic Press
Release Date : 2020-11-12
Biomedical Applications Of Microfluidic Devices written by Michael R. Hamblin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-12 with Technology & Engineering categories.
Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. - Covers basic principles and design of microfluidics devices - Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery - Includes chemical applications in organic and inorganic chemistry - Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students
Organ On A Chip
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Author : Julia Hoeng
language : en
Publisher: Academic Press
Release Date : 2019-11-09
Organ On A Chip written by Julia Hoeng and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-09 with Technology & Engineering categories.
Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models. - Includes case studies of other organs on a chip that have been developed and successfully used - Provides insights into functional microphysiological organ on a chip platforms for toxicity and efficacy testing, along with opportunities for translational medicine - Presented fields (PK/PD, physiology, medicine, safety) are given a definition followed by the challenges and potential of organs on a chip
Microfluidic Cell Culture Systems
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Author : Christopher Bettinger
language : en
Publisher: William Andrew
Release Date : 2012-12-31
Microfluidic Cell Culture Systems written by Christopher Bettinger and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.
The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by biological applications. The goal is to guide new and interested researchers and technology developers to the important areas and state-of-the-practice strategies that will enhance the efficiency and value of their technologies, devices and biomedical products. - Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications - Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell culture - Provides balanced coverage of microsystems engineering and bioengineering
Biochip Technology
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Author : Jing Cheng
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Biochip Technology written by Jing Cheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Science categories.
Biochip technology has experienced explosive growth in recent years and Biochip technology describes the basic manufacturing and fabrication processes and the current range of applications of these chips. Top scientists from the biochip industry and related areas explain the diverse applications of biochips in gene sequencing, expression monitoring, disease diagnosis, tumor examination, ligand assay and drug discovery.