Minimal Residual Disease In Acute Leukemia 1986
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Minimal Residual Disease In Acute Leukemia 1986
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Author : A. Hagenbeek
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Minimal Residual Disease In Acute Leukemia 1986 written by A. Hagenbeek and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Relapse of leukemia following successful remission-induction therapy remains a major obstacle in the treatment of patients with acute leukemia. Leukemia recurs most frequently in patients with acute myeloblastic leukemia (AML) and high risk acute lymphoblastic leukemia (ALL) following chemotherapy and less often in patients with low risk ALL and particularly in patient groups> submitted to allogeneic marrow transplantation. ' It is likely that the great majority of these recurrences originate from residual leukemic cells that survive initial remission-induction chemotherapy. Today, several research groups throughout the world place emphasis on studies concerned with the detection and treatment of 'minimal residual disease' (MRD). These investigations are conducted with the common objective to tackle the remaining cells. 'Minimal Residual Disease in Acute Leukemia: 1986' summarizes the fast advancements in this area. Several disciplines are concerned with the analysis of leukemic cells. The perspectives of cytogenetic and molecular genetic approaches for applica tion in the detection of MRD are reviewed. In this respect, modern cyto genetics provide highly specific tumor markers. The resolution of cyto genetic methods can be particularly improved when combined with other techniques which select relevant subpopulations of cells. Characterization of oncogenes and gene rearrangements, including those of immunoglobulin and T-cell receptor genes, and the measurement of gene products, have been established. Techniques based on these approaches offer interesting tools for the detection of MRD. New possibilities of employing monoclonal anti bodies are also presented.
Minimal Residual Disease An Acute Leukemia
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Author : Bob Löwenberg
language : en
Publisher:
Release Date : 1984
Minimal Residual Disease An Acute Leukemia written by Bob Löwenberg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with categories.
Leukemia And Lymphoma
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Author : Theodore F. Zipf
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-10-21
Leukemia And Lymphoma written by Theodore F. Zipf and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-10-21 with Medical categories.
In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for leukemias and lymphomas. They apply reverse transcription PCR (RT-PCR) to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for Non-Hodgkin's Lymphoma and for the monitoring of follicular lymphoma. Additional chapters address the use of real-time quantitative PCR (RQ-PCR), the emergent method of choice, in patients with acute lymphoblastic leukemia (ALL), the evaluation of MRD techniques in clinical trials, and the application of flow cytometry techniques.
Minimal Residual Disease In Acute Leukemia
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Author :
language : en
Publisher:
Release Date : 1990
Minimal Residual Disease In Acute Leukemia written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
Minimal Residual Disease In Hematologic Malignancies
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Author : Raanani P Ed
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 2004
Minimal Residual Disease In Hematologic Malignancies written by Raanani P Ed and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Blood categories.
Detection of minimal residual disease (MRD) is increasingly used in the management of leukemia patients. A wide variety of methods have been developed and include technologies designed to detect residual malignant cells beyond the sensitivity of conventional approaches such as morphology and banding cytogenetics in leukemia. The choice of the best method depends on the biology of the individual malignancy, i.e. on the determination of specific markers which are useful to differentiate between leukemic cells and normal hematopoiesis in leukemic patients. These markers include leukocyte differentiation antigens, fusion transcripts, transcripts overexpressed by mutated or nonmutated genes, rearranged genes, and individual markers like polymorphic repetitive DNA sequences. The major technologies for MRD detection, their advantages and disadvantages and their clinical applications are discussed in this special issue - from 'bench to bedside'. Providing a comprehensive overview on the significance of MRD in the evaluation, treatment and follow-up of hematologic malignancies, it will be of great value to hematologists, researchers interested in leukemias and lymphomas as well as laboratory technicians.
Clinical Management Of Acute Lymphoblastic Leukemia
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Author : Mark R. Litzow
language : en
Publisher: Springer Nature
Release Date : 2022-01-01
Clinical Management Of Acute Lymphoblastic Leukemia written by Mark R. Litzow and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-01 with Medical categories.
This book provides a state-of-the-art overview of acute lymphoblastic leukemia (ALL). The first section of the book presents the translational science behind ALL, reviewing molecular pathways and targets in B- and T-cell ALL, as well as techniques and application of minimal residual disease testing. The second section spotlights ALL management strategies for patients across the spectrum, from infants to the elderly. The final section outlines current and new advances in ALL treatment, including new monoclonal antibodies and allogenic and autologous HSCT. Written by experts in the field, Clinical Management of Acute Lymphoblastic Leukemia: From Bench to Bedside is a valuable resource that will guide patient management, stimulate investigative efforts, and increase understanding of the biologic underpinnings of the disease.
Childhood Acute Lymphoblastic Leukemia
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Author : Ajay Vora
language : en
Publisher: Springer
Release Date : 2017-04-21
Childhood Acute Lymphoblastic Leukemia written by Ajay Vora and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-21 with Medical categories.
This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
Normal And Malignant B Cell
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Author : Mourad Aribi
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-02-26
Normal And Malignant B Cell written by Mourad Aribi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-26 with Medical categories.
Normal and Malignant B-Cell is a collection of harmonious chapters contributed by different authors. This book sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and etiopathogenic aspects when it is transformed into a malignant cell. The book will be interesting and useful for clinicians, biologists, researchers, teachers, and graduate students of both doctoral and master's degrees in the field of immunology.
Multiparameter Flow Cytometry In The Diagnosis Of Hematologic Malignancies
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Author : Anna Porwit
language : en
Publisher: Cambridge University Press
Release Date : 2018-01-25
Multiparameter Flow Cytometry In The Diagnosis Of Hematologic Malignancies written by Anna Porwit and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-25 with Medical categories.
This practical manual offers an active understanding of how to implement flow-cytometry when facing complex, haematological diseases.
Paediatric Haematology And Oncology
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Author : Simon Bailey
language : en
Publisher: Oxford University Press, USA
Release Date : 2010
Paediatric Haematology And Oncology written by Simon Bailey and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
While survival rates for children with cancer have increased in recent times, the increased use of more aggressive therapies has brought with it significant adverse effects. Therefore, the aim of pediatric oncologists has become to achieve "cure at least cost" by the appropriate reduction of the intensity and/or duration of treatment in carefully identified good prognosis patients. By comprehensively covering these issues, this handbook aims to provide residents in pediatric hematology and oncology, as well as staff in related medical or other healthcare disciplines, with an easily accessible source of information about the basic principles of childhood cancer and leukemia, as well as much of the more detailed specialist knowledge required to care for children with these conditions. Divided into sections to allow quick access to the necessary information, the handbook covers general principles of diagnosis and treatment, short and long term care, and oncological emergencies before moving on to chapters on specific disease. Normal values and useful websites are also included for reference.