Mitochondria In Neurological Disorders
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Mitochondria And Brain Disorders
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Author : Stavros Baloyannis
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-11
Mitochondria And Brain Disorders written by Stavros Baloyannis and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-11 with Medical categories.
The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders.
Mitochondria In Neurological Disorders
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Author : Rajat Sandhir
language : en
Publisher: Academic Press
Release Date : 2021-12-01
Mitochondria In Neurological Disorders written by Rajat Sandhir and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-01 with Medical categories.
Mitochondria in Neurological Diseases highlights various therapeutic approaches targeting mitochondria in neurological conditions. Focused on diverse neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, depression, and Amyotrophic lateral sclerosis, topics span basic mitochondrial physiology to mitochondrial dynamics and to the altered states of the nervous system. This book is appropriate for anyone interested in learning more about the physiological and pathophysiological functions of mitochondria in the nervous system. Provides up-to-date information on role of mitochondria in nervous system for graduate students and researchers Presents chapters on energy substrate utilization, calcium handling, mitochondria-organelle communication, and cell signaling Discusses recent techniques in understanding mitochondrial functions in the nervous system Emphasizes the role of altered mitochondrial functions in various neurological conditions and their potential treatment strategies for targeting mitochondria Includes chapter references (key articles, books, protocols) for additional detailed study
Mitochondrial Disorders In Neurology
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Author : Anthony H.V. Schapira
language : en
Publisher: Butterworth-Heinemann
Release Date : 2013-10-22
Mitochondrial Disorders In Neurology written by Anthony H.V. Schapira and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Mitochondrial Disorders in Neurology provides an overview of mitochondrial diseases. This book discusses the effects of mitochondrial dysfunction based on the relevant biochemistry and molecular genetics. The abnormal muscle and mitochondrial morphology in a variety of clinical presentations from isolated ophthalmoplegia to severe encephalopathy are also elaborated. This text likewise deliberates Leber's hereditary optic neuropathy, neurodegenerative disorders, and respiratory chain defects. Other topics covered include mitochondrial DNA and the genetics of mitochondrial disease; cytochrome oxidase deficiency; use of tissue culture in the diagnosis of mitochondrial disease; and advances in mitochondrial genetics. This publication is a good source for clinicians and students concerned with the defective mitochondrial function.
Mitochondrial Dysfunction In Neurodegenerative Disorders
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Author : Amy Katherine Reeve
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-15
Mitochondrial Dysfunction In Neurodegenerative Disorders written by Amy Katherine Reeve and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-15 with Medical categories.
As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration. Mitochondrial Dysfunction in Neurodegenerative Disorders brings together contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of these diseases, guiding the reader through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, to the consequences of this dysfunction on neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.
The Functions Disease Related Dysfunctions And Therapeutic Targeting Of Neuronal Mitochondria
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Author : J. Marie Hardwick
language : en
Publisher: John Wiley & Sons
Release Date : 2015-09-25
The Functions Disease Related Dysfunctions And Therapeutic Targeting Of Neuronal Mitochondria written by J. Marie Hardwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-25 with Medical categories.
This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. • Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death • Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments • Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field • Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders
Mitochondrial Dynamics And Neurodegeneration
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Author : Bingwei Lu
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-05-16
Mitochondrial Dynamics And Neurodegeneration written by Bingwei Lu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-16 with Medical categories.
Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
Neuro Mitochondrial Nexus
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Author : Mayur Kale
language : en
Publisher:
Release Date : 2024-02-24
Neuro Mitochondrial Nexus written by Mayur Kale and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-24 with Science categories.
Mitochondria are central to neuronal health, serving as the primary energy producers within cells. This vital role makes them a focal point in understanding various neurological disorders. Across conditions such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis, neuroinflammatory disorders, neurodevelopmental disorders, stroke, and traumatic brain injury (TBI), mitochondrial dysfunction emerges as a common thread. In Alzheimer's disease, for instance, dysfunctional mitochondria contribute to the accumulation of amyloid-beta plaques and tau protein tangles, accelerating neurodegeneration. Similarly, in Parkinson's disease, mitochondrial impairment disrupts cellular energy production, exacerbating the loss of dopaminergic neurons and leading to motor dysfunction. ALS, characterized by the progressive degeneration of motor neurons, also exhibits mitochondrial dysfunction, further contributing to the disease pathology. Additionally, in conditions like multiple sclerosis and neuroinflammatory disorders, dysfunctional mitochondria exacerbate inflammation and neuronal damage. The role of mitochondria extends beyond neurodegenerative diseases; in neurodevelopmental disorders such as autism and intellectual disabilities, disturbances in mitochondrial dynamics impact neuronal connectivity and synaptic function. Furthermore, mitochondrial impairment plays a significant role in acute neurological insults like stroke and TBI, exacerbating neuronal injury and complicating recovery processes. Despite the challenges posed by mitochondrial dysfunction in neurological disorders, there is growing interest in mitochondrial therapeutics as a promising avenue for neuroprotection and disease modification. Investigating the neuroprotective potential of mitochondrial-targeted interventions opens new avenues for therapeutic development and offers hope for mitigating the impact of mitochondrial dysfunction across a spectrum of neurological conditions.
Mitochondrial Dynamics And Neurodegeneration
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Author : Bingwei Lu
language : en
Publisher: Springer
Release Date : 2013-01-02
Mitochondrial Dynamics And Neurodegeneration written by Bingwei Lu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-02 with Medical categories.
Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
Diagnosis And Management Of Mitochondrial Disorders
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Author : Michelangelo Mancuso
language : en
Publisher: Springer
Release Date : 2019-05-03
Diagnosis And Management Of Mitochondrial Disorders written by Michelangelo Mancuso and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-03 with Medical categories.
This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world’s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.
Mitochondrial Disorders In Neurology 2
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Author : Anthony Henry Vernon Schapira
language : en
Publisher: Butterworth-Heinemann
Release Date : 2002
Mitochondrial Disorders In Neurology 2 written by Anthony Henry Vernon Schapira and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
Gain practical explanations of the science underlying mitochondrial disorders in neurology. Written by leading experts, this new Blue Book helps you recognize and manage the diseases. Includes: Sections on the role of mitochondria in neurodegenerative disease The development of animal models for mitochondrial diseases The design of treatments for patients with mitochondrial defects