Mitochondrial Dna Mitochondria Disease And Stem Cells
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Mitochondrial Dna Mitochondria Disease And Stem Cells
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Author : Justin C. St. John
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-26
Mitochondrial Dna Mitochondria Disease And Stem Cells written by Justin C. St. John and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-26 with Science categories.
This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.
Mitochondrial Dna Mitochondria Disease And Stem Cells
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Author : Justin C. St. John
language : en
Publisher: Humana Press
Release Date : 2012-09-27
Mitochondrial Dna Mitochondria Disease And Stem Cells written by Justin C. St. John and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-27 with Science categories.
This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.
Mitochondrial Dna And Diseases
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Author : Hongzhi Sun
language : en
Publisher: Springer
Release Date : 2017-11-25
Mitochondrial Dna And Diseases written by Hongzhi Sun and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-25 with Science categories.
The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.
Mitochondrial Disorders
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Author : Claude Desnuelle
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-01
Mitochondrial Disorders written by Claude Desnuelle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-01 with Medical categories.
The concept of mitochondrial diseases originated in 1962 with the description by Luft and coworkers of a patient with nonthyroidal hypermetabolism due to loose coupling of oxidation and phosphorylation in muscle mitochondria. Over the following quarter of a century, thanks to W. King Engel's "ragged-red fibres" as convenient markers for mitochondrial pathology, numerous papers described clinical, morphological, and biochemical features of "mitochondrial myopathies." In 1988 the discovery of mutations in mitochondrial DNA led to an explosive expansion of research into mitochondrial disorders. Throughout the 1990s the rapid identification of multiple mitochondrial gene defects associated with clinically diverse disorders has left practitioners puzzled about diagnosing such heterogeneous and complex syndromes. Through updated data, this book discusses now what Luft aptly called "mitochondrial medicine." In so doing, it considers the pivotal role of mitochondria in drug sensitivity, their key roles in ageing, apoptosis, and neurodegeneration along with primary mitochondrial diseases due to mutations in the nuclear genome, in the mitochondrial genome, or in the cross-talk between the two genomes.
Cellular And Molecular Basis Of Mitochondrial Inheritance
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Author : Peter Sutovsky
language : en
Publisher: Springer
Release Date : 2019-05-09
Cellular And Molecular Basis Of Mitochondrial Inheritance written by Peter Sutovsky and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-09 with Science categories.
This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.
Mitochondrial Disorders Caused By Nuclear Genes
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Author : Lee-Jun C. Wong
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-18
Mitochondrial Disorders Caused By Nuclear Genes written by Lee-Jun C. Wong and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-18 with Medical categories.
Mitochondrial cytopathies are mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation. Mitochondrial respiratory chain disorders (RCD) are a group of genetically and clinically heterogeneous diseases, due to the fact that protein components of the respiratory chain are encoded by both mitochondrial and nuclear genomes and are essential in all cells. In addition, the biogenesis, structure and function of mitochondria, including DNA replication, transcription, and translation, all require nuclear encoded genes. Since mitochondria are present in every cell, every tissue, mitochondrial disorder usually affects multiple organs.
Mitochondria And Their Role In Cardiovascular Disease
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Author : José Marín-García
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-19
Mitochondria And Their Role In Cardiovascular Disease written by José Marín-García and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-19 with Medical categories.
Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.
The Human Mitochondrial Genome
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Author : Giuseppe Gasparre
language : en
Publisher: Academic Press
Release Date : 2020-08-19
The Human Mitochondrial Genome written by Giuseppe Gasparre and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-19 with Science categories.
The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists
Mitochondrial Dna
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Author : Shiv Sanjeevi
language : en
Publisher: Delve Publishing
Release Date : 2019-11
Mitochondrial Dna written by Shiv Sanjeevi and has been published by Delve Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11 with Science categories.
Mitochondrial DNA: The Works takes into account the overview of mitochondria along with its dna and inheritance. It also comprises the interest aspects and glimpses of research related to the mitochondrial dna. It provides the reader with the insights of mitochondrial dna and its interesting aspects so as to understand the advances in methods for reducing mitochondrial dna disease by replacing or manipulating the mitochondrial genome, reaction of human cells in the absence of mitochondrial dna and variants of mitochondrial dna in case of obesity. This book also discusses about regulation of mitochondrial genome inheritance by autophagy and ubiquitin-proteasome system: implications for health, fitness, and fertility, advances in methods for reducing mitochondrial dna disease by replacing or manipulating the mitochondrial genome, mitochondrial dna variants in obesity and research on plants for the understanding of diseases of nuclear and mitochondrial origin.
Mitochondria And Longevity
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-07-31
Mitochondria And Longevity written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-31 with Science categories.
Mitochondria and Longevity, Volume 340, the latest release in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics with this release focusing on topics such as Mitochondria metabolism and aging, Mitohormesis, Mitochondrial dynamics in the aging stem cell compartment, Mitochondrial proteostasis and aging, Mitochondrial DNA mutations and aging, Mitochondrial sirtuins, NAD+, NADH and aging, Mitophagy and aging, Mitochondria, calcium transport and aging. Publishes only invited review articles on selected topics in cell and molecular biology Authored by established and active cell and molecular biologists Drawn from international sources Offers a wide range of perspectives on specific subjects