Mitochondrial Dynamics In Cardiovascular Medicine
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Mitochondrial Dynamics In Cardiovascular Medicine
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Author : Gaetano Santulli
language : en
Publisher: Springer
Release Date : 2017-05-25
Mitochondrial Dynamics In Cardiovascular Medicine written by Gaetano Santulli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-25 with Science categories.
This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.
Mitochondria And Their Role In Cardiovascular Disease
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Author : José Marín-García
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-19
Mitochondria And Their Role In Cardiovascular Disease written by José Marín-García and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-19 with Medical categories.
Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.
Mitochondria And Their Role In Cardiovascular Disease
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Author : José Marín-García
language : en
Publisher: Springer
Release Date : 2012-11-17
Mitochondria And Their Role In Cardiovascular Disease written by José Marín-García and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-17 with Medical categories.
Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.
Mitochondrial Dysfunction And Cardiovascular Diseases
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Author : Sebastiano Sciarretta
language : en
Publisher: Frontiers Media SA
Release Date : 2021-03-04
Mitochondrial Dysfunction And Cardiovascular Diseases written by Sebastiano Sciarretta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-04 with Medical categories.
Mitochondrial Remodeling And Dynamic Inter Organellar Contacts In Cardiovascular Physiopathology
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Author : Giampaolo Morciano
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-21
Mitochondrial Remodeling And Dynamic Inter Organellar Contacts In Cardiovascular Physiopathology written by Giampaolo Morciano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-21 with Science categories.
Mitochondria And The Heart
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Author : José Marín-García
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-05-05
Mitochondria And The Heart written by José Marín-García and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-05 with Medical categories.
Mitochondria have been pivotal in the development of some of the most important ideas in modern biology. Since the discovery that the organelle has its own DNA and specific mutations were found in association with neuromuscular and cardiovascular diseases and with aging, an extraordi-nary number of publications have followed, and the term mitochondrial medicine was coined. Furthermore, our understanding of the multiple roles that mitochondria play in cardiac cell homeostasis opened the door for intensive experimentation to understand the pathogenesis and to find new treatments for cardiovascular diseases. Besides its role in adenosine triphosphate generation, mitochondria regu-late a complex network of cellular interactions, involving (1) generation and detoxification of reactive oxygen species, including superoxide anion, hy-drogen peroxide, and hydroxyl radical; (2) maintenance of the antioxidant glutathione in a reduced state and adequate level of mitochondrial matrix superoxide dismutase; (3) cytoplasmic calcium homeostasis, particularly under conditions of cellular calcium loading; (4) transport of metabolites between cytoplasm and matrix; (5) both programmed (apoptosis) and necrotic cell death; and (6) cell growth and development. It is therefore not surprising that this organelle has come to be the center stage in many current investigations of cardiovascular diseases, aging, and agi- related disease. Concomitant with these advances, an impressive effort is under- way for the development of new tools and methodologies to study mitochondrial structure and function, including powerful ways to visualize, monitor, and alter the organelle function to assess the genetic consequences of these perturbations.
Mitochondrial Metabolism In Ischemic Heart Disease
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Author : Shijun Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-27
Mitochondrial Metabolism In Ischemic Heart Disease written by Shijun Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Medical categories.
Mitochondria
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Author : Stephen W. Schaffer
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-02-24
Mitochondria written by Stephen W. Schaffer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-24 with Science categories.
This book is indispensable to researchers in fields as diverse as Molecular Biology and Biophysics. It covers the important role that mitochondria play in a variety of biochemical spheres. It analyses how mitochondria affect metabolic pathways, how they are active in the regulation of cytosolic constituents, and their role in initiating signal pathways. Also covered are the way mitochondria help to regulate apoptosis, and how they modulate cellular hypertrophy and proliferation. It gives an overview of the emergence of mitochondria as an important regulator of cell signaling, with a particular focus on their pathophysiology.
Metabolic Cardiomyopathy
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Author : H. Böhles
language : en
Publisher: CRC Press
Release Date : 2004
Metabolic Cardiomyopathy written by H. Böhles and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cardiomyopathy categories.
During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.
Myocardial Protection
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Author : Derek M. Yellon
language : en
Publisher:
Release Date : 1992
Myocardial Protection written by Derek M. Yellon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
An insight into the theories and controversies regarding myocardial reperfusion and reperfusion-induced injury. The ideas presented advance the understanding of the relationship of reperfusion injury to the beneficial effects of restoring coronary flow to the myocardium after an ischemic insult.