Mitochondrial Gene Expression
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Mitochondrial Gene Expression
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Author : Michal Minczuk
language : en
Publisher: Humana
Release Date : 2020-12-03
Mitochondrial Gene Expression written by Michal Minczuk and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-03 with Medical categories.
This volume details the most recent advancements in the field of mitochondrial gene expression. Chapters guide readers through methods and protocols on mtDNA replication, transcription, and translation to membrane insertion of the mtDNA-encoded protein products. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mitochondrial Gene Expression: Methods and Protocols aims to provide complementary approaches and practical guidelines. Chapter 7 is available Open Access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Mitochondrial Biogenesis And Genetics
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Author : Giuseppe Attardi
language : en
Publisher: Gulf Professional Publishing
Release Date : 1996
Mitochondrial Biogenesis And Genetics written by Giuseppe Attardi and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Aging categories.
The critically acclaimed laboratory standard for forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerlyawaited, frequently consulted, and praised by researchers and reviewers alike. More than 250 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features * Structural and functional analysis of oxidative phosphorylation complexes * Import of proteins and RNA into mitochondria * Ion and metabolite transport systems in mitochondria * Biophysical methods for mitochondrial function analysis * Mitochondrial inheritance and turnover.
Regulation Of Human Mitochondrial Gene Expression
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Author : Maria Isabel Guadalupe Lopez Sanchez
language : en
Publisher:
Release Date : 2014
Regulation Of Human Mitochondrial Gene Expression written by Maria Isabel Guadalupe Lopez Sanchez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Human mitochondrial DNA is a distinct, compact genetic system that encodes proteins crucial for energy metabolism in the cell. Due to its reduced size and relatively simple organisation, all the regulatory factors directing the expression of the mitochondrial genome are encoded by nuclear DNA. It is evident that mitochondrial gene expression is regulated at different levels, which is reflected by the numerous diseases associated with mutations in both nuclear and mitochondrial DNA-encoded mitochondrial proteins. Research focusing on the identification and characterisation of RNA-binding proteins as regulators of mitochondrial function is ongoing. However, the components and mechanisms involved in the post-transcriptional regulation of mitochondrial DNA are not well understood. The aim of this research project was to investigate different aspects of the regulation of human mitochondrial gene expression via the direct action of nuclear-encoded mitochondrial proteins on RNA metabolism. First, I validated the proteins responsible for 5' end processing of mitochondrial precursor transcripts and identified the protein responsible for 3' end processing cleavage, showing that they are important for mitochondrial function. Next, I studied a previously uncharacterised mitochondrial ribosomal subunit protein and found that it is an important factor in the regulation of protein synthesis. Finally, I examined a protein that has multiple and independent functions in the organelle and identified it as a new target for the estrogenic modulation of mitochondrial gene expression via the estrogen receptor alpha. Both the nuclear and the mitochondrial genomes contribute to the mitochondrial proteome and hence to mitochondrial function. Because mitochondria possess a genome that is central to multiple cellular functions, understanding the different levels and mechanisms involved in the regulation of mitochondrial gene expression is essential in elucidating the contribution of mitochondrial dysfunction to human disease.
Coordinated Regulation Of Yeast Nuclear And Mitochondrial Gene Expression
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Author : Terrie Lorraine Ulery
language : en
Publisher:
Release Date : 1993
Coordinated Regulation Of Yeast Nuclear And Mitochondrial Gene Expression written by Terrie Lorraine Ulery and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Mitochondrial Genome Evolution
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-11-27
Mitochondrial Genome Evolution written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-27 with Science categories.
Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume features reviews on Mitochondrial genome evolution. Publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology This thematic volume features reviews on mitochondrial genome evolution
Mitochondrial Gene Expression
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Author :
language : en
Publisher:
Release Date : 2021
Mitochondrial Gene Expression written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Gene expression categories.
Mitochondrial Gene Expression
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Author : Michal Minczuk
language : en
Publisher: Humana
Release Date : 2021-12-08
Mitochondrial Gene Expression written by Michal Minczuk and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-08 with Medical categories.
This volume details the most recent advancements in the field of mitochondrial gene expression. Chapters guide readers through methods and protocols on mtDNA replication, transcription, and translation to membrane insertion of the mtDNA-encoded protein products. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mitochondrial Gene Expression: Methods and Protocols aims to provide complementary approaches and practical guidelines. Chapter 7 is available Open Access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Rna Metabolism In Mitochondria
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Author : Jorge Cruz-Reyes
language : en
Publisher: Springer
Release Date : 2018-06-12
Rna Metabolism In Mitochondria written by Jorge Cruz-Reyes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-12 with Science categories.
This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism; tRNA processing of 5′ and 3′ ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.
Plant Mitochondria From Genome To Function
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Author : David Day
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-09
Plant Mitochondria From Genome To Function written by David Day and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-09 with Science categories.
Mitochondria in plants, as in other eukaryotes, play an essential role in the cell as the major producers of ATP via oxidative phosphorylation. However, mitochondria also play crucial roles in many other aspects of plant development and performance, and possess an array of unique properties which allow them to interact with the specialized features of plant cell metabolism. The two main themes running through the book are the interconnection between gene regulation and protein function, and the integration of mitochondria with other components of plant cells. The book begins with an overview of the dynamics of mitochondrial structure, morphology and inheritance. It then discusses the biogenesis of mitochondria, the regulation of gene expression, the mitochondrial genome and its interaction with the nucleus, and the targeting of proteins to the organelle. This is followed by a discussion of the contributions that mutations, involving mitochondrial proteins, have made to our understanding of the way the organelle interacts with the rest of the plant cell, and the new field of proteomics and the discovery of new functions. Also covered are the pathways of electron transport, with special attention to the non-phosphorylating bypasses, metabolite transport, and specialized mitochondrial metabolism. In the end, the impact of oxidative stress on mitochondria and the defense mechanisms, that are employed to allow survival, are discussed. This book is for the use of advanced undergraduates, graduates, postgraduates, and beginning researchers in the areas of molecular and cellular biology, integrative biology, biochemistry, bioenergetics, proteomics and plant and agricultural sciences.
Mitochondrial Oxidative Phosphorylation
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Author : Bernhard Kadenbach
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-23
Mitochondrial Oxidative Phosphorylation written by Bernhard Kadenbach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-23 with Medical categories.
This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.