Mobile Genetic Elements In Cellular Differentiation Genome Stability And Cancer
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Mobile Genetic Elements In Cellular Differentiation Genome Stability And Cancer
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Author : Tammy A. Morrish
language : en
Publisher: Frontiers Media SA
Release Date : 2018-01-16
Mobile Genetic Elements In Cellular Differentiation Genome Stability And Cancer written by Tammy A. Morrish and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-16 with categories.
The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS). To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.
Structure And Function Of The Genetic Apparatus
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Author : Claudio Nicolini
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Structure And Function Of The Genetic Apparatus written by Claudio Nicolini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The Fourth Course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held September 18-31, 1983 at the Ettore Majorana Center for Scientific Culture in Erice, Sicily. The subject of the Fourth Course, which was co-sponsored by national and international agencies, was "Structure and Function of the Genetic "Appara tus. " Participants from 15 countries around the world attended the course. The study of the genetic apparatus is one of humanity's most challeng ing problems, and it has been approached in the tradition of the School from many different points of view, among them biochemistry, genetic eng ineering, cell biology, oncology, biophysics and other fields. It has been most difficult to confine such diverse points of view, as well as their pro ponents, within the four walls of one room, in front of one audience - es pecially since the heterogeneity of background and the inherent difficul ties encountered in communication could overshadow the true spirit of sci entific exchange. We are once again pleased to say the outcome of the 1983 Course has matched the success of the previous course held in Erice on the same subject five years ago. This book is the result of the 1983 Advanced Study Institute, and aims to present a cohesive, interdisciplinary view of the current knowledge on the structure and fuction of the genetic apparatus.
International Cancer Congress
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Author :
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1986-08-22
International Cancer Congress written by and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-08-22 with Medical categories.
Systems Biology Of Cancer
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Author : Sam Thiagalingam
language : en
Publisher: Cambridge University Press
Release Date : 2015-04-09
Systems Biology Of Cancer written by Sam Thiagalingam and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-09 with Mathematics categories.
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Noncoding Rna
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-08-28
Noncoding Rna written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-28 with Science categories.
Noncoding RNAs (ncRNAs) are the “dark matter” of the genome, occupying vast regions yet not coding for proteins. Despite their elusive nature, they play a pivotal role in regulating gene expression and cellular processes and participate in chromatin remodeling and signal transduction. Crucial in development and disease, ncRNAs influence embryogenesis, cell differentiation, and cancer progression. Their potential in diagnostics and therapeutics marks a revolutionary frontier in genetic and medical research. This book provides a comprehensive overview of the regulatory and developmental roles of ncRNAs, from gene regulation in plants to their crucial functions in embryogenesis and cancer, and their potential in diagnostics and therapeutics.
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Author : Taylor & Francis Group
language : en
Publisher: Garland Science
Release Date : 2010-12-31
written by Taylor & Francis Group and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-31 with categories.
Oncogenes
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Author : Enrique Pimentel
language : en
Publisher: CRC Press
Release Date : 2020-04-02
Oncogenes written by Enrique Pimentel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-02 with Medical categories.
First published in 1986, this comprehensive work focuses on the "Acute and Chronic Transforming Retroviruses," "Cellular and Viral Oncogenes," "Functions of Oncogene and Protooncogene Protein Products," and "Oncogenes and Cancer." The number of oncogenes presently identified has grown to more than double of that which was discussed in the first edition of this book. It more clearly explains the relation of protooncogenes to neoplastic diseases, especially to human cancer. This updated edition is an absolute must for all physicians and biologists.
Hypoxia
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Author : Robert C. Roach
language : en
Publisher: Springer
Release Date : 2016-06-24
Hypoxia written by Robert C. Roach and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-24 with Medical categories.
The latest in a series of books from the International Hypoxia Symposia, this volume spans reviews on key topics in hypoxia, and abstracts from poster and oral presentations. The biannual International Hypoxia Symposia are dedicated to hosting the best basic scientific and clinical minds to focus on the integrative and translational biology of hypoxia. Long before ‘translational medicine’ was a catchphrase, the founders of the International Hypoxia Symposia brought together basic scientists, clinicians and physiologists to live, eat, ski, innovate and collaborate in the Canadian Rockies. This collection of reviews and abstracts is divided into six sections, each covering new and important work relevant to a broad range of researchers interested in how humans adjust to hypoxia, whether on the top of Mt. Everest or in the pulmonary or cardiology clinic at low altitude. The sections include: Epigenetic Variations in Hypoxia High Altitude Adaptation Hypoxia and Sleep Hypoxia and the Brain Molecular Oxygen Sensing Physiological Responses to Hypoxia
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
The Elusive Road Towards Effective Cancer Prevention And Treatment
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Author : Franklyn De Silva
language : en
Publisher: CRC Press
Release Date : 2022-10-28
The Elusive Road Towards Effective Cancer Prevention And Treatment written by Franklyn De Silva and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-28 with Medical categories.
Cancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text. Features : This book summarizes the current status, successes, difficulties, advancements, limitations, and challenges in medical interventions that impact patients’ quality of life. Includes concise descriptions of all relevant cell and molecular biology concepts including evolutionary paradigms, hallmarks of cancer, and heterogeneity to help understand the pathophysiology of cancer, cancer-associated disease conditions, and effective cancer therapy. Contains an array of colorful figures and schematics summarizing complex informative pathological, physiological, and biochemical concepts. Covers a multitude of sub-topics pertaining to cancer biology including diagnosis; chemotherapy, radiotherapy and targeted therapy; metastasis; disseminated and circulating tumor cells, and cancer stem cells; drug resistance and cellular reprogramming; complex epigenetics; tumor-derived exosomes; oncogenic viruses; metabolic syndrome and cancer metabolism; convoluted neovascularization; efficient biomarkers; immunotherapy; role of nutraceuticals and natural products. Provides perspectives on how to improve pre-clinical understandings, and outcomes, linking toxicological, and pharmacological aspects in patient care. This timely, relevant comprehensive assortment of scientific literature has educational value to a wider audience including as part of an academic course, seminar, or as a supplementary text.