Model Systems To Study The Mechanisms Of Neural Development And Disease
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Model Systems To Study The Mechanisms Of Neural Development And Disease
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Author : Parthiv Haldipur
language : en
Publisher: Frontiers Media SA
Release Date :
Model Systems To Study The Mechanisms Of Neural Development And Disease written by Parthiv Haldipur and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on with Science categories.
Molecular Mechanisms Of Neural Development And Insights Into Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-03-09
Molecular Mechanisms Of Neural Development And Insights Into Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-09 with Science categories.
Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters by one or more members of an international board of authors. Sections in this new release cover The role of primary cilia in neural development and disease, Mechanisms of axon guidance receptor regulation and signaling, Synaptic recognition molecules in development and disease, The regulation of cortical neurogenesis, Axon guidance in the developing spinal cord, The role of astrocytes in synapse formation and maturation, Development of motor circuits, Molecular mechanisms that mediate dendrite morphogenesis, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series
Model Systems Of Development And Aging Of The Nervous System
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Author : Antonia Vernadakis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Model Systems Of Development And Aging Of The Nervous System written by Antonia Vernadakis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The last decade has generated a multitude of studies using in vitro model systems to explore growth and differentiation of the nervous system. Although the findings have been exciting and have revealed unique properties of neural cells, considerable concern continues to be expressed regarding the significance of in vitro findings in terms of their applicability to in vivo biological events. To examine this issue further, a group of scientists pre sented and discussed their findings at a conference sponsored by the Institute of Developmental Neuroscience and Aging held in Crete, Greece, 26-29 May 1985. The conference was cosponsored by the University of Crete and was generously supported by the Ministry of Research and Technology of Greece, Tourism Organization of Greece, and also Sandoz and FIDIA. The Directors of the Institute of Developmental Neuroscience and Aging are indebted to these Institutions for their support. For the success of this conference, the Directors owe much to Drs. Eleni Fleischer-Lambropoulos and Yiannis Tsouderos, who spent countless hours in making arrangements so that the participants would have not only a scientific, but also a unique cultural, experience. Several chapters of this book focus on the complex phenomena of neurogenesis and gliogenesis, and the modulation of neuronal differentiation. The concept that neuronal differentiation has both genetic and epigenetic components is documented by elegant studies using both in vitro cultured cells and neurons transplanted in vivo.
Molecular And Cellular Approaches To Neural Development
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Author : W. Maxwell Cowan
language : en
Publisher: Oxford University Press, USA
Release Date : 1997
Molecular And Cellular Approaches To Neural Development written by W. Maxwell Cowan and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
This text provides a broad but authoritative view of the cellular and molecular aspects of developmental neurobiology written by leaders in the field.
Therapeutic Development In The Absence Of Predictive Animal Models Of Nervous System Disorders
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-05-24
Therapeutic Development In The Absence Of Predictive Animal Models Of Nervous System Disorders written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-24 with Medical categories.
Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a retraction in investment from the pharmaceutical industry. This retreat by industry has been fueled by the high failure rate of compounds in advanced clinical trials for nervous system disorders. In response to the de-emphasis of CNS disorders in therapeutic development relative to other disease areas such as cancer, metabolism, and autoimmunity, the National Academies of Sciences, Engineering, and Medicine initiated a series of workshops in 2012 to address the challenges that have slowed drug development for nervous system disorders. Motivated by the notion that advances in genetics and other new technologies are beginning to bring forth new molecular targets and identify new biomarkers, the Academies hosted the third workshop in this series in September 2016. Participants discussed opportunities to accelerate early stages of drug development for nervous system disorders in the absence of animal models that reflect disease and predict efficacy. This publication summarizes the presentations and discussions from the workshop.
Mechanisms Of Neural Cell Genesis In Development And Disease
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Author : Robert H. Miller
language : en
Publisher: S Karger Ag
Release Date : 2001-01-01
Mechanisms Of Neural Cell Genesis In Development And Disease written by Robert H. Miller and has been published by S Karger Ag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-01 with Medical categories.
New advances in understanding the generation of cell diversity in the developing vertebrate nervous system are presented, bringing together different perspectives and approaches as well as the use of different biological systems under a general theme. As a result, the reader is able to draw from a vast resource of information. In addition to studies on development, some articles concentrate on disease and allow direct comparison of the molecular mechanisms implicated in both development and disease. Developmental neuroscientists who are interested in neural cell fate determination as well as people working in areas of neural disease such as multiple sclerosis will profit most from this issue.
Epigenetic Regulation In The Nervous System
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Author : J. David Sweatt
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Epigenetic Regulation In The Nervous System written by J. David Sweatt and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.
Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics
Cellular And Molecular Biology Of Neuronal Development
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Author : Ira Black
language : en
Publisher: Springer
Release Date : 1984-03
Cellular And Molecular Biology Of Neuronal Development written by Ira Black and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984-03 with Medical categories.
A central problem in neurobiology concerns mechanisms that generate the pro found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-
Mouse Models Of Development And Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2022-04-20
Mouse Models Of Development And Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-20 with Science categories.
Mouse Models of Development and Disease, Volume 148 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this volume presenting chapters describing Mouse models of Charcot-Marie-Tooth disease, Mouse models in palate and craniofacial development, Uterine morphogenesis, Improving the translatability of mouse models of Alzheimer's disease, Mouse models for the study of clustered protocadherins, Mechanisms of organ regeneration in the spiny mouse, Comparative studies of organ vascularization, Modeling human urinary tract development and hereditary malformations, Innervation in organogenesis, Between embryo and adult: somatic growth of the kidney, and Mouse models in the study of Notch signaling. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on Mouse Models of Development and Disease
Targeted Therapies For Neurodevelopmental Disorders
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Author : Ethan M. Goldberg
language : en
Publisher:
Release Date : 2021
Targeted Therapies For Neurodevelopmental Disorders written by Ethan M. Goldberg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.