Modeling In Biopharmaceutics Pharmacokinetics And Pharmacodynamics

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Modeling In Biopharmaceutics Pharmacokinetics And Pharmacodynamics

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Author : Panos Macheras
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-26

Modeling In Biopharmaceutics Pharmacokinetics And Pharmacodynamics written by Panos Macheras and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-26 with Mathematics categories.

This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

Pharmacokinetic Pharmacodynamic Modeling And Simulation

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Author : Peter L. Bonate
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-07-01

Pharmacokinetic Pharmacodynamic Modeling And Simulation written by Peter L. Bonate and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-01 with Medical categories.

This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.

Advances In Pharmacokinetics And Pharmacodynamics

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Author : Panos Macheras
language : en
Publisher: Springer Nature
Release Date : 2023-05-26

Advances In Pharmacokinetics And Pharmacodynamics written by Panos Macheras and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-26 with Science categories.

This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.

Basic Pharmacokinetics And Pharmacodynamics

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Author : Sara E. Rosenbaum
language : en
Publisher: John Wiley & Sons
Release Date : 2016-12-27

Basic Pharmacokinetics And Pharmacodynamics written by Sara E. Rosenbaum and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-27 with Medical categories.

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)

Handbook Of Pharmacokinetic Pharmacodynamic Correlation

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Author : Hartmut Derendorf
language : en
Publisher: CRC Press
Release Date : 1995-03-23

Handbook Of Pharmacokinetic Pharmacodynamic Correlation written by Hartmut Derendorf and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-23 with Medical categories.

Combining the established disciplines of pharmacokinetics (PK), the relationship between drug concentration and time, and pharmacodynamics (PD), the relationship between drug effects and concentration, this handbook examines the relevant relationship between drug effects and time. It provides a systematic overview of how PK is linked to PD, introduces the basic concepts of PK-PD modeling and presents the underlying theory behind it, and discusses the specific aspects of PK-PD modeling for various classes of drugs.

Basic Pharmacokinetics And Pharmacodynamics

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Author : Sara E. Rosenbaum
language : en
Publisher: John Wiley & Sons
Release Date : 2012-09-10

Basic Pharmacokinetics And Pharmacodynamics written by Sara E. Rosenbaum and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-10 with Medical categories.

With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.

Pharmacokinetic And Pharmacodynamic Data Analysis Concepts And Applications Third Edition

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Author : Johan Gabrielsson
language : en
Publisher: CRC Press
Release Date : 2001-11-30

Pharmacokinetic And Pharmacodynamic Data Analysis Concepts And Applications Third Edition written by Johan Gabrielsson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-30 with Medical categories.

This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.

Advanced Methods Of Pharmacokinetic And Pharmacodynamic Systems Analysis

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Author : David D'Argenio
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Advanced Methods Of Pharmacokinetic And Pharmacodynamic Systems Analysis written by David D'Argenio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.

This volume records the proceedings of the Workshop on Advanced Meth ods of Pharmacokinetic and Pharmacodynamic Systems Analysis, organized by the Biomedical Simulations Resource in May 1990. The meeting brought together over 120 investigators from a number of disciplines, including clinical pharmacology, clinical pharmacy, pharmaceutical science, biomathematics, statistics and biomed ical engineering with the purpose of providing a high-level forum to facilitate the exchange of ideas between basic and clinical research scientists, experimentalists and modelers working on problems in pharmacokinetics and pharmacodynamics. It has been my experience that in many areas of biomedical research, when a meeting of this type is held, the general attitude of those experimentalists willing to attend is one of extreme skepticism: as a group they feel that mathematical modeling has little to offer them in furthering their understanding of the particular biological processes they are studying. This is certainly not the prevailing view when the topic is pharmacokinetics and drug response. Quite the contrary, the use of mathemati cal modeling and associated data analysis and computational methods has been a central feature of pharmacokinetics almost from its beginnings. In fact, the field has borrowed techniques of modeling from other disciplines including applied math ematics, statistics and engineering, in an effort to better describe and understand the processes of drug disposition and drug response.

Simulation For Designing Clinical Trials

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Author : Hui Kimko
language : en
Publisher: CRC Press
Release Date : 2002-12-12

Simulation For Designing Clinical Trials written by Hui Kimko and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-12 with Medical categories.

Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation p

Introduction To Population Pharmacokinetic Pharmacodynamic Analysis With Nonlinear Mixed Effects Models

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Author : Joel S. Owen
language : en
Publisher: John Wiley & Sons
Release Date : 2014-06-19

Introduction To Population Pharmacokinetic Pharmacodynamic Analysis With Nonlinear Mixed Effects Models written by Joel S. Owen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-19 with Medical categories.

This book provides a user-friendly, hands-on introduction to theNonlinear Mixed Effects Modeling (NONMEM) system, the most powerfultool for pharmacokinetic / pharmacodynamic analysis. • Introduces requisite background to using NonlinearMixed Effects Modeling (NONMEM), covering data requirements, modelbuilding and evaluation, and quality control aspects • Provides examples of nonlinear modeling concepts andestimation basics with discussion on the model buildingprocess and applications of empirical Bayesian estimates in thedrug development environment • Includes detailed chapters on data set structure,developing control streams for modeling and simulation, modelapplications, interpretation of NONMEM output and results, andquality control • Has datasets, programming code, and practice exerciseswith solutions, available on a supplementary website