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Models And Methods For Biological Evolution


Models And Methods For Biological Evolution
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Models And Methods For Biological Evolution


Models And Methods For Biological Evolution
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Author : Gilles Didier
language : en
Publisher: John Wiley & Sons
Release Date : 2024-04-10

Models And Methods For Biological Evolution written by Gilles Didier and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-10 with Science categories.


Biological evolution is the phenomenon concerning how species are born, are transformed or disappear over time. Its study relies on sophisticated methods that involve both mathematical modeling of the biological processes at play and the design of efficient algorithms to fit these models to genetic and morphological data. Models and Methods for Biological Evolution outlines the main methods to study evolution and provides a broad overview illustrating the variety of formal approaches used, notably including combinatorial optimization, stochastic models and statistical inference techniques. Some of the most relevant applications of these methods are detailed, concerning, for example, the study of migratory events of ancient human populations or the progression of epidemics. This book should thus be of interest to applied mathematicians interested in central problems in biology, and to biologists eager to get a deeper understanding of widely used techniques of evolutionary data analysis.



A Biologist S Guide To Mathematical Modeling In Ecology And Evolution


A Biologist S Guide To Mathematical Modeling In Ecology And Evolution
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Author : Sarah P. Otto
language : en
Publisher: Princeton University Press
Release Date : 2011-09-19

A Biologist S Guide To Mathematical Modeling In Ecology And Evolution written by Sarah P. Otto and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-19 with Science categories.


Thirty years ago, biologists could get by with a rudimentary grasp of mathematics and modeling. Not so today. In seeking to answer fundamental questions about how biological systems function and change over time, the modern biologist is as likely to rely on sophisticated mathematical and computer-based models as traditional fieldwork. In this book, Sarah Otto and Troy Day provide biology students with the tools necessary to both interpret models and to build their own. The book starts at an elementary level of mathematical modeling, assuming that the reader has had high school mathematics and first-year calculus. Otto and Day then gradually build in depth and complexity, from classic models in ecology and evolution to more intricate class-structured and probabilistic models. The authors provide primers with instructive exercises to introduce readers to the more advanced subjects of linear algebra and probability theory. Through examples, they describe how models have been used to understand such topics as the spread of HIV, chaos, the age structure of a country, speciation, and extinction. Ecologists and evolutionary biologists today need enough mathematical training to be able to assess the power and limits of biological models and to develop theories and models themselves. This innovative book will be an indispensable guide to the world of mathematical models for the next generation of biologists. A how-to guide for developing new mathematical models in biology Provides step-by-step recipes for constructing and analyzing models Interesting biological applications Explores classical models in ecology and evolution Questions at the end of every chapter Primers cover important mathematical topics Exercises with answers Appendixes summarize useful rules Labs and advanced material available



Methods And Models In Mathematical Biology


Methods And Models In Mathematical Biology
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Author : Johannes Müller
language : en
Publisher: Springer
Release Date : 2015-08-13

Methods And Models In Mathematical Biology written by Johannes Müller and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-13 with Mathematics categories.


This book developed from classes in mathematical biology taught by the authors over several years at the Technische Universität München. The main themes are modeling principles, mathematical principles for the analysis of these models and model-based analysis of data. The key topics of modern biomathematics are covered: ecology, epidemiology, biochemistry, regulatory networks, neuronal networks and population genetics. A variety of mathematical methods are introduced, ranging from ordinary and partial differential equations to stochastic graph theory and branching processes. A special emphasis is placed on the interplay between stochastic and deterministic models.



Modern Phylogenetic Comparative Methods And Their Application In Evolutionary Biology


Modern Phylogenetic Comparative Methods And Their Application In Evolutionary Biology
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Author : László Zsolt Garamszegi
language : en
Publisher: Springer
Release Date : 2016-09-22

Modern Phylogenetic Comparative Methods And Their Application In Evolutionary Biology written by László Zsolt Garamszegi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-22 with Science categories.


Phylogenetic comparative approaches are powerful analytical tools for making evolutionary inferences from interspecific data and phylogenies. The phylogenetic toolkit available to evolutionary biologists is currently growing at an incredible speed, but most methodological papers are published in the specialized statistical literature and many are incomprehensible for the user community. This textbook provides an overview of several newly developed phylogenetic comparative methods that allow to investigate a broad array of questions on how phenotypic characters evolve along the branches of phylogeny and how such mechanisms shape complex animal communities and interspecific interactions. The individual chapters were written by the leading experts in the field and using a language that is accessible for practicing evolutionary biologists. The authors carefully explain the philosophy behind different methodologies and provide pointers – mostly using a dynamically developing online interface – on how these methods can be implemented in practice. These “conceptual” and “practical” materials are essential for expanding the qualification of both students and scientists, but also offer a valuable resource for educators. Another value of the book are the accompanying online resources (available at: http://www.mpcm-evolution.com), where the authors post and permanently update practical materials to help embed methods into practice.



Models Of Life


Models Of Life
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Author : Kim Sneppen
language : en
Publisher: Cambridge University Press
Release Date : 2014-10-02

Models Of Life written by Kim Sneppen and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-02 with Science categories.


An overview of current models of biological systems, reflecting the major advances that have been made over the past decade.



Computational Molecular Evolution


Computational Molecular Evolution
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Author : Ziheng Yang
language : en
Publisher: OUP Oxford
Release Date : 2006-10-05

Computational Molecular Evolution written by Ziheng Yang and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-05 with Science categories.


The field of molecular evolution has experienced explosive growth in recent years due to the rapid accumulation of genetic sequence data, continuous improvements to computer hardware and software, and the development of sophisticated analytical methods. The increasing availability of large genomic data sets requires powerful statistical methods to analyse and interpret them, generating both computational and conceptual challenges for the field. Computational Molecular Evolution provides an up-to-date and comprehensive coverage of modern statistical and computational methods used in molecular evolutionary analysis, such as maximum likelihood and Bayesian statistics. Yang describes the models, methods and algorithms that are most useful for analysing the ever-increasing supply of molecular sequence data, with a view to furthering our understanding of the evolution of genes and genomes. The book emphasizes essential concepts rather than mathematical proofs. It includes detailed derivations and implementation details, as well as numerous illustrations, worked examples, and exercises. It will be of relevance and use to students and professional researchers (both empiricists and theoreticians) in the fields of molecular phylogenetics, evolutionary biology, population genetics, mathematics, statistics and computer science. Biologists who have used phylogenetic software programs to analyze their own data will find the book particularly rewarding, although it should appeal to anyone seeking an authoritative overview of this exciting area of computational biology.



Computational Modeling Of Biological Systems


Computational Modeling Of Biological Systems
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Author : Nikolay V Dokholyan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-12

Computational Modeling Of Biological Systems written by Nikolay V Dokholyan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-12 with Science categories.


Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to model, visualize, and rationally alter systems at various length scales, starting from molecular modeling and design at atomic resolution to cellular pathways modeling and analysis. Higher time and length scale processes, such as molecular evolution, have also greatly benefited from new breeds of computational approaches. This book provides an overview of the established computational methods used for modeling biologically and medically relevant systems.



Modern Phylogenetic Comparative Methods And Their Application In Evolutionary Biology


Modern Phylogenetic Comparative Methods And Their Application In Evolutionary Biology
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Author : László Zsolt Garamszegi
language : en
Publisher: Springer
Release Date : 2014-07-29

Modern Phylogenetic Comparative Methods And Their Application In Evolutionary Biology written by László Zsolt Garamszegi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-29 with Science categories.


Phylogenetic comparative approaches are powerful analytical tools for making evolutionary inferences from interspecific data and phylogenies. The phylogenetic toolkit available to evolutionary biologists is currently growing at an incredible speed, but most methodological papers are published in the specialized statistical literature and many are incomprehensible for the user community. This textbook provides an overview of several newly developed phylogenetic comparative methods that allow to investigate a broad array of questions on how phenotypic characters evolve along the branches of phylogeny and how such mechanisms shape complex animal communities and interspecific interactions. The individual chapters were written by the leading experts in the field and using a language that is accessible for practicing evolutionary biologists. The authors carefully explain the philosophy behind different methodologies and provide pointers – mostly using a dynamically developing online interface – on how these methods can be implemented in practice. These “conceptual” and “practical” materials are essential for expanding the qualification of both students and scientists, but also offer a valuable resource for educators. Another value of the book are the accompanying online resources (available at: http://www.mpcm-evolution.com), where the authors post and permanently update practical materials to help embed methods into practice.



From Genes To Personalized Healthcare


From Genes To Personalized Healthcare
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Author : Nicolas Jacq
language : en
Publisher: IOS Press
Release Date : 2007

From Genes To Personalized Healthcare written by Nicolas Jacq and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.


The main focus of this publication is on technologies, solutions and requirements that interest the grid and the life-science communities to foster the integration of grids into health. The proceedings are especially interesting for grid middleware and grid application developers, biomedical and health informatics users, and security and policy makers with a common focus on the application in the health domain. Topics in this publication are: State-of-the-art of the grid research and use at molecule, cell, organ, individual and population levels; and security and imaging. In security, data protection and pseudonymization are being discussed. In imaging, there's Globus MEDICUS, which federates DICOM devices through a grid architecture and KnowARC on facilitating grid networks for the biomedical research community. Finally, there's a report on the successful use of multimodal workflows in diabetic retinopathy research.



Modeling Methods For Medical Systems Biology


Modeling Methods For Medical Systems Biology
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Author : María Elena Álvarez-Buylla Roces
language : en
Publisher: Springer
Release Date : 2018-08-03

Modeling Methods For Medical Systems Biology written by María Elena Álvarez-Buylla Roces and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-03 with Science categories.


This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.