Modern Biostatistical Principles And Conduct
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Modern Biostatistical Principles And Conduct
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Author : Laurens Holmes, Jr
language : en
Publisher: Laurens Holmes, Jr
Release Date : 2025-03-14
Modern Biostatistical Principles And Conduct written by Laurens Holmes, Jr and has been published by Laurens Holmes, Jr this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-14 with Medical categories.
Modern Biostatistical Principles & Conduct - Clinical Medicine and Public/Population Health Assessment Clinical medicine or surgery continues to make advances through evidence that is judged to be objectively drawn from the care of individual patients. The natural observation of individuals remains the basis for our researchable questions’ formulation and the subsequent hypothesis testing. Evidence-based medicine or surgery depends on how critical we are in evaluating evidence in order to inform our practice. These evaluations no matter how objective are never absolute but probabilistic, as we will never know with absolute certainty how to treat future patients who were not a part of our study. Despite the obstacles facing us today in an attempt to provide an objective evaluation of our patients, since all our decisions are based on a judgment of some evidence, we have progressed from expert opinion to the body of evidence from randomized controlled clinical trials, as well as cohort investigations, prospective and retrospective. The conduct of clinical trials though termed the “gold standard”, which yields more reliable and valid evidence from the data relative to non-experimental or observational designs, depends on how well it is designed and conducted prior to outcomes data collection, analysis, results, interpretation, and dissemination. The designs and the techniques used to draw statistical inferences are often beyond the average clinician’s understanding. A text that brings hypothesis formulation, analysis, and how to interpret the results of the findings is long overdue and highly anticipated. Statistical modeling which is fundamentally a journey from sample to the application of findings is essential to evidence discovery. This text, Modern Biostatistics for Clinical, Biomedical and Population-Based Researchers has filled this gap, not only in the way complex modeling is explained but the simplification of statistical techniques in a way that had never been explained before. This text has been prepared intentionally at the rudimentary level to benefit clinicians without sophisticated mathematical backgrounds or previous advanced knowledge of biostatics as applied statistics in health and medicine. Also, biomedical researchers who may want to conduct clinical research, as well as consumers of research products may benefit from the sampling techniques, their relevance to scientific evidence discovery as well a simplified approach to statistical modeling of clinical and biomedical research data. It is with this expectation and enthusiasm that we recommend this text to clinicians in all fields of clinical and biomedical research. One’s experience with biomedical research and how the findings in this arm are translated to the clinical environment signals the need for the application of biological, and clinical relevance of findings prior to statistical inference. The examples provided by the author to simplify research methods are familiar to orthopedic surgeons as well as clinicians in other specialties of medicine and surgery. Whereas statistical inference is essential in our application of the research findings to clinical decision-making regarding the care of our patients, statistical inference without clinical relevance or importance can be very misleading, and meaningless. The authors have attempted to deemphasize the p-value in the interpretation of clinical and biomedical research findings, by stressing the importance of confidence intervals, which allow for the quantification of evidence. For example, a large study due to a large sample size that minimizes variability may show a statistically significant difference while in reality, the difference is too insignificant to warrant any clinical importance. In contrast, a small study as frequently seen in most clinical trials or surgical research may have a large effect size of clinical relevance but not statistically significant at (p > 0.05). Thus, without considering the magnitude of the effect size with the confidence interval, we tend to regard these studies as negative findings, which is erroneous, since the absence of evidence, simply on the basis of an arbitrary significance level of 5% does not necessarily mean evidence of absence.1 In effect, clinical research results, cannot be adequately interpreted without first considering the biological and clinical significance of the data, before the statistical stability of the findings (p-value and 95% Confidence Interval), since the p-value as observed by the authors merely reflects the size of the study and not the measure of evidence. In recommending this text, it is one’s inclination that this book will benefit clinicians, research fellows, clinical fellows, postdoctoral students in biomedical and clinical settings, nurses, clinical research coordinators, physical therapists, and all those involved in clinical research design, conduct, and analysis of research data for statistical and clinical relevance. Convincingly, knowledge gained from this text will lead to our improvement of patient care through well-conceptualized research. Therefore, with the knowledge that no book is complete, no matter its content or volume, especially a book of this nature, which is prepared to guide clinicians on sampling, statistical modeling of data, and interpretation of findings, this book will benefit clinicians who are interested in applying appropriate statistical technique to scientific evidence discovery. Finally, we are optimistic that this book will bridge the gap in knowledge and practice of clinical and biomedical research, especially for clinicians in busy practice who are passionate about making a difference in their patient's care through scientific research initiatives.
Modern Biostatistical Principles And Concepts
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Author : Laurens Holmes, Jr
language : en
Publisher: Laurens Holmes, Jr
Release Date : 2025-03-19
Modern Biostatistical Principles And Concepts written by Laurens Holmes, Jr and has been published by Laurens Holmes, Jr this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-19 with Medical categories.
Modern Biostatistical Principles and Concepts - Clinical Medicine and Public/Population Health Assessment Clinical medicine or surgery continues to make advances through evidence that is judged to be objectively drawn from the care of individual patients. The natural observation of individuals remains the basis for our researchable questions’ formulation and the subsequent hypothesis testing. Evidence-based medicine or surgery depends on how critical we are in evaluating evidence in order to inform our practice. These evaluations no matter how objective are never absolute but probabilistic, as we will never know with absolute certainty how to treat future patients who were not a part of our study. Despite the obstacles facing us today in an attempt to provide an objective evaluation of our patients, since all our decisions are based on a judgment of some evidence, we have progressed from expert opinion to the body of evidence from randomized controlled clinical trials, as well as cohort investigations, prospective and retrospective. The conduct of clinical trials though termed the “gold standard”, which yields more reliable and valid evidence from the data relative to non-experimental or observational designs, depends on how well it is designed and conducted prior to outcomes data collection, analysis, results, interpretation, and dissemination. The designs and the techniques used to draw statistical inferences are often beyond the average clinician’s understanding. A text that brings hypothesis formulation, analysis, and how to interpret the results of the findings is long overdue and highly anticipated. Statistical modeling which is fundamentally a journey from sample to the application of findings is essential to evidence discovery. This text, Modern Biostatistics for Clinical, Biomedical and Population-Based Researchers has filled this gap, not only in the way complex modeling is explained but the simplification of statistical techniques in a way that had never been explained before. This text has been prepared intentionally at the rudimentary level to benefit clinicians without sophisticated mathematical backgrounds or previous advanced knowledge of biostatics as applied statistics in health and medicine. Also, biomedical researchers who may want to conduct clinical research, as well as consumers of research products may benefit from the sampling techniques, their relevance to scientific evidence discovery as well a simplified approach to statistical modeling of clinical and biomedical research data. It is with this expectation and enthusiasm that we recommend this text to clinicians in all fields of clinical and biomedical research. One’s experience with biomedical research and how the findings in this arm are translated to the clinical environment signals the need for the application of biological, and clinical relevance of findings prior to statistical inference. The examples provided by the author to simplify research methods are familiar to orthopedic surgeons as well as clinicians in other specialties of medicine and surgery. Whereas statistical inference is essential in our application of the research findings to clinical decision-making regarding the care of our patients, statistical inference without clinical relevance or importance can be very misleading, and meaningless. The authors have attempted to deemphasize the p-value in the interpretation of clinical and biomedical research findings, by stressing the importance of confidence intervals, which allow for the quantification of evidence. For example, a large study due to a large sample size that minimizes variability may show a statistically significant difference while in reality, the difference is too insignificant to warrant any clinical importance. In contrast, a small study as frequently seen in most clinical trials or surgical research may have a large effect size of clinical relevance but not statistically significant at (p > 0.05). Thus, without considering the magnitude of the effect size with the confidence interval, we tend to regard these studies as negative findings, which is erroneous, since the absence of evidence, simply on the basis of an arbitrary significance level of 5% does not necessarily mean evidence of absence.1 In effect, clinical research results, cannot be adequately interpreted without first considering the biological and clinical significance of the data, before the statistical stability of the findings (p-value and 95% Confidence Interval), since the p-value as observed by the authors merely reflects the size of the study and not the measure of evidence. In recommending this text, it is one’s inclination that this book will benefit clinicians, research fellows, clinical fellows, postdoctoral students in biomedical and clinical settings, nurses, clinical research coordinators, physical therapists, and all those involved in clinical research design, conduct, and analysis of research data for statistical and clinical relevance. Convincingly, knowledge gained from this text will lead to our improvement of patient care through well-conceptualized research. Therefore, with the knowledge that no book is complete, no matter its content or volume, especially a book of this nature, which is prepared to guide clinicians on sampling, statistical modeling of data, and interpretation of findings, this book will benefit clinicians who are interested in applying appropriate statistical technique to scientific evidence discovery. Finally, we are optimistic that this book will bridge the gap in knowledge and practice of clinical and biomedical research, especially for clinicians in busy practice who are passionate about making a difference in their patient's care through scientific research initiatives.
Fundamentals Of Modern Statistical Methods
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Author : Rand R. Wilcox
language : en
Publisher: Springer
Release Date : 2010-03-10
Fundamentals Of Modern Statistical Methods written by Rand R. Wilcox and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Social Science categories.
Conventional statistical methods have a very serious flaw. They routinely miss differences among groups or associations among variables that are detected by more modern techniques, even under very small departures from normality. Hundreds of journal articles have described the reasons standard techniques can be unsatisfactory, but simple, intuitive explanations are generally unavailable. Situations arise where even highly nonsignificant results become significant when analyzed with more modern methods. Without assuming the reader has any prior training in statistics, Part I of this book describes basic statistical principles from a point of view that makes their shortcomings intuitive and easy to understand. The emphasis is on verbal and graphical descriptions of concepts. Part II describes modern methods that address the problems covered in Part I. Using data from actual studies, many examples are included to illustrate the practical problems with conventional procedures and how more modern methods can make a substantial difference in the conclusions reached in many areas of statistical research. The second edition of this book includes a number of advances and insights that have occurred since the first edition appeared. Included are new results relevant to medians, regression, measures of association, strategies for comparing dependent groups, methods for dealing with heteroscedasticity, and measures of effect size.
Concise Biostatistical Principles And Concepts
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Author : Laurens Holmes, Jr
language : en
Publisher: Laurens Holmes, Jr
Release Date : 2025-03-18
Concise Biostatistical Principles And Concepts written by Laurens Holmes, Jr and has been published by Laurens Holmes, Jr this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-18 with Medical categories.
Concise Biostatistical Principles and Concepts, 2nd Edition Clinical medicine or surgery continues to make advances through evidence that is judged to be objectively drawn from the care of individual patients. The natural observation of individuals remains the basis for our researchable questions’ formulation and the subsequent hypothesis testing. Evidence-based medicine or surgery depends on how critical we are in evaluating evidence in order to inform our practice. These evaluations no matter how objective are never absolute but probabilistic, as we will never know with absolute certainty how to treat future patients who were not a part of our study. Despite the obstacles facing us today in an attempt to provide an objective evaluation of our patients, since all our decisions are based on a judgment of some evidence, we have progressed from expert opinion to the body of evidence from randomized controlled clinical trials, as well as cohort investigations, prospective and retrospective. The conduct of clinical trials though termed the “gold standard”, which yields more reliable and valid evidence from the data relative to non-experimental or observational designs, depends on how well it is designed and conducted prior to outcomes data collection, analysis, results, interpretation, and dissemination. The designs and the techniques used to draw statistical inferences are often beyond the average clinician’s understanding. A text that brings hypothesis formulation, analysis, and how to interpret the results of the findings is long overdue and highly anticipated. Statistical modeling which is fundamentally a journey from sample to the application of findings is essential to evidence discovery. The four past decades have experienced modern advances in statistical modeling and evidence discovery in biomedical, clinical, and population-based research. With these advances come the challenges in accurate model stipulation and application of models in scientific evidence discovery. While the application of novel statistical techniques to our data is necessary and fundamental to research, the selection of a sample and sampling method that reflects the representativeness of that sample to the targeted population is even more important. Since one of the rationale behind research conduct is to generate new knowledge and apply it to improve life situations including the improvement of patient and population health, sampling, sample size, and power estimations remain the basis for such inference. With the essential relevance of sample and sampling technique to how we come to make sense of data, the design of the study transcends statistical technique, since no statistical tool no matter how sophisticated can correct the errors of sampling. This text is written to highlight the importance of appropriate design prior to analysis by placing emphasis on subject selection and probability sample, randomization process when applicable prior to the selection of the analytic tool. In addition, it stresses the importance of biological and clinical significance in the interpretation of study findings. The basis for statistical inference, implying the quantification of random error is a random sample. When studies are conducted without random samples as often encountered in clinical and biomedical research, it is meaningless to report the findings with p value. However, in the absence of a random sample, the p-value can be applied to designs that utilize consecutive samples, and disease registries, since these samples reflect the population of interest, and hence representative sample, justifying inference and generalization. Essential to the selection of test statistics is the understanding of the scale of the measurement of the variables, especially the response, outcome or dependent variable, type of sample (independent or correlated), hypothesis, and normality assumption. In terms of the selection of statistical tests, this text is based on the scale of measurement (binary), type of sample (single, independent), and relationship (linear). For example, if the scale of measurement of the outcome variable is binary, repeated measure, and normality is not assumed, the repeated measure logistic regression model remains a feasible model for evidence discovery in using the independent variables to predict the repeated outcome. This book presents a simplified approach to evidence discovery by recommending the graphic illustration of data and normality test for continuous (ratio/interval scale) data prior to statistical test selection. Unlike current text in biostatistics, the approach taken to present these materials is very simple. First, this text uses applied statistics by illustrating what, when, where, and why a test is appropriate. Where a text violates the normality assumption, readers are presented with a non-parametric alternative. The rationale for the test is explained with a limited mathematical formula and is intended in order to stress the applied nature of biostatistics. Attempts have been made in this book to present the most commonly used statistical model in biomedical or clinical research. We believe since no book is complete to have covered the basics that will facilitate the understanding of scientific evidence discovery. We hope this book remains a useful guide, which is our intention in bridging the gap between theoretical statistical models and reality in the statistical modeling of biomedical and clinical research data. As researchers we all make mistakes and we believe we have learned from our mistakes during the past three decades hence the need to examine flaws and apply reality in the statistical modeling of biomedical and research data. We hope this text results in increased reliability in the conduct, analysis,
Concise Biostatistical Principles And Concepts 2nd Edition
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Author : Laurens Holmes, Jr
language : en
Publisher: Laurens Holmes, Jr
Release Date : 2025-03-18
Concise Biostatistical Principles And Concepts 2nd Edition written by Laurens Holmes, Jr and has been published by Laurens Holmes, Jr this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-18 with Medical categories.
Concise Biostatistical Principles and Concepts - Statistical Reality in Evidence Discovery Clinical medicine or surgery continues to make advances through evidence that is judged to be objectively drawn from the care of individual patients. The natural observation of individuals remains the basis for our researchable questions’ formulation and the subsequent hypothesis testing. Evidence-based medicine or surgery depends on how critical we are in evaluating evidence in order to inform our practice. These evaluations no matter how objective are never absolute but probabilistic, as we will never know with absolute certainty how to treat future patients who were not a part of our study. Despite the obstacles facing us today in an attempt to provide an objective evaluation of our patients, since all our decisions are based on a judgment of some evidence, we have progressed from expert opinion to the body of evidence from randomized controlled clinical trials, as well as cohort investigations, prospective and retrospective. The conduct of clinical trials though termed the “gold standard”, which yields more reliable and valid evidence from the data relative to non-experimental or observational designs, depends on how well it is designed and conducted prior to outcomes data collection, analysis, results, interpretation, and dissemination. The designs and the techniques used to draw statistical inferences are often beyond the average clinician’s understanding. A text that brings hypothesis formulation, analysis, and how to interpret the results of the findings is long overdue and highly anticipated. Statistical modeling which is fundamentally a journey from sample to the application of findings is essential to evidence discovery. The four past decades have experienced modern advances in statistical modeling and evidence discovery in biomedical, clinical, and population-based research. With these advances come the challenges in accurate model stipulation and application of models in scientific evidence discovery. While the application of novel statistical techniques to our data is necessary and fundamental to research, the selection of a sample and sampling method that reflects the representativeness of that sample to the targeted population is even more important. Since one of the rationale behind research conduct is to generate new knowledge and apply it to improve life situations including the improvement of patient and population health, sampling, sample size, and power estimations remain the basis for such inference. With the essential relevance of sample and sampling technique to how we come to make sense of data, the design of the study transcends statistical technique, since no statistical tool no matter how sophisticated can correct the errors of sampling. This text is written to highlight the importance of appropriate design prior to analysis by placing emphasis on subject selection and probability sample, randomization process when applicable prior to the selection of the analytic tool. In addition, it stresses the importance of biological and clinical significance in the interpretation of study findings. The basis for statistical inference, implying the quantification of random error is a random sample. When studies are conducted without random samples as often encountered in clinical and biomedical research, it is meaningless to report the findings with p value. However, in the absence of a random sample, the p-value can be applied to designs that utilize consecutive samples, and disease registries, since these samples reflect the population of interest, and hence representative sample, justifying inference and generalization. Essential to the selection of test statistics is the understanding of the scale of the measurement of the variables, especially the response, outcome or dependent variable, type of sample (independent or correlated), hypothesis, and normality assumption. In terms of the selection of statistical tests, this text is based on the scale of measurement (binary), type of sample (single, independent), and relationship (linear). For example, if the scale of measurement of the outcome variable is binary, repeated measure, and normality is not assumed, the repeated measure logistic regression model remains a feasible model for evidence discovery in using the independent variables to predict the repeated outcome. This book presents a simplified approach to evidence discovery by recommending the graphic illustration of data and normality test for continuous (ratio/interval scale) data prior to statistical test selection. Unlike current text in biostatistics, the approach taken to present these materials is very simple. First, this text uses applied statistics by illustrating what, when, where, and why a test is appropriate. Where a text violates the normality assumption, readers are presented with a non-parametric alternative. The rationale for the test is explained with a limited mathematical formula and is intended in order to stress the applied nature of biostatistics. Attempts have been made in this book to present the most commonly used statistical model in biomedical or clinical research. We believe since no book is complete to have covered the basics that will facilitate the understanding of scientific evidence discovery. We hope this book remains a useful guide, which is our intention in bridging the gap between theoretical statistical models and reality in the statistical modeling of biomedical and clinical research data. As researchers we all make mistakes and we believe we have learned from our mistakes during the past three decades hence the need to examine flaws and apply reality in the statistical modeling of biomedical and research data. We hope this text results in increased reliability in the conduct, analysis
Biostatistics
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Author : Wayne W. Daniel
language : en
Publisher: John Wiley & Sons
Release Date : 2018-11-13
Biostatistics written by Wayne W. Daniel and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-13 with Medical categories.
The ability to analyze and interpret enormous amounts of data has become a prerequisite for success in allied healthcare and the health sciences. Now in its 11th edition, Biostatistics: A Foundation for Analysis in the Health Sciences continues to offer in-depth guidance toward biostatistical concepts, techniques, and practical applications in the modern healthcare setting. Comprehensive in scope yet detailed in coverage, this text helps students understand—and appropriately use—probability distributions, sampling distributions, estimation, hypothesis testing, variance analysis, regression, correlation analysis, and other statistical tools fundamental to the science and practice of medicine. Clearly-defined pedagogical tools help students stay up-to-date on new material, and an emphasis on statistical software allows faster, more accurate calculation while putting the focus on the underlying concepts rather than the math. Students develop highly relevant skills in inferential and differential statistical techniques, equipping them with the ability to organize, summarize, and interpret large bodies of data. Suitable for both graduate and advanced undergraduate coursework, this text retains the rigor required for use as a professional reference.
Modern Issues And Methods In Biostatistics
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Author : Mark Chang
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-07-15
Modern Issues And Methods In Biostatistics written by Mark Chang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-15 with Medical categories.
Classic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a confluence of statistics and knowledge of multiple intertwined fields. The application demands, the advancements in computer technology, and the rapid growth of life science data (e.g., genomics data) have promoted the formation of modern biostatistics. There are at least three characteristics of modern biostatistics: (1) in-depth engagement in the application fields that require penetration of knowledge across several fields, (2) high-level complexity of data because they are longitudinal, incomplete, or latent because they are heterogeneous due to a mixture of data or experiment types, because of high-dimensionality, which may make meaningful reduction impossible, or because of extremely small or large size; and (3) dynamics, the speed of development in methodology and analyses, has to match the fast growth of data with a constantly changing face. This book is written for researchers, biostatisticians/statisticians, and scientists who are interested in quantitative analyses. The goal is to introduce modern methods in biostatistics and help researchers and students quickly grasp key concepts and methods. Many methods can solve the same problem and many problems can be solved by the same method, which becomes apparent when those topics are discussed in this single volume.
Introductory Statistics And Random Phenomena
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Author : Manfred Denker
language : en
Publisher: Birkhäuser
Release Date : 2017-09-16
Introductory Statistics And Random Phenomena written by Manfred Denker and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-16 with Computers categories.
This textbook integrates traditional statistical data analysis with new computational experimentation capabilities and concepts of algorithmic complexity and chaotic behavior in nonlinear dynamic systems. This was the first advanced text/reference to bring together such a comprehensive variety of tools for the study of random phenomena occurring in engineering and the natural, life, and social sciences. The crucial computer experiments are conducted using the readily available computer program Mathematica® Uncertain Virtual WorldsTM software packages which optimize and facilitate the simulation environment. Brief tutorials are included that explain how to use the Mathematica® programs for effective simulation and computer experiments. Large and original real-life data sets are introduced and analyzed as a model for independent study. This is an excellent classroom tool and self-study guide. The material is presented in a clear and accessible style providing numerous exercises and bibliographical notes suggesting further reading. Topics and Features Comprehensive and integrated treatment of uncertainty arising in engineering and scientific phenomena – algorithmic complexity, statistical independence, and nonlinear chaotic behavior Extensive exercise sets, examples, and Mathematica® computer experiments that reinforce concepts and algorithmic methods Thorough presentation of methods of data compression and representation Algorithmic approach to model selection and design of experiments Large data sets and 13 Mathematica®-based Uncertain Virtual WorldsTM programs and code This text is an excellent resource for all applied statisticians, engineers, and scientists who need to use modern statistical analysis methods to investigate and model their data. The present, softcover reprint is designed to make this classic textbook available to a wider audience.
The Handbook Of Political Behavior
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Author : Samuel Long
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
The Handbook Of Political Behavior written by Samuel Long and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Political Science categories.
On Revolutions That Never Were "If you want to understand what a science is," the anthropologist Clifford Geertz (1973, p. 5) has written, "you should look in the first instance not at its theories or its findings, and certainly not at what its apologists say about it; you should look at what the practitioners of it do. " If it is not always possible to follow this instruction, it is because the rate of change in scientific work is rapid and the growth of publications reporting on this work is great. It is therefore the task of a handbook, like this Hand book of Political Behavior, to summarize and evaluate what the practi tioners report. But it is always prudent to keep in mind that a handbook is only a shortcut and that there is no substitute for looking directly at what the practitioners of a science do. For when scientists are "at work" (Walter, 1971), the image of what they are doing is often quite different from that conveyed in the "briefs" that, in their own way, make a hand book so valuable that we cannot do without it. These reflections set the stage.
Family Planning News
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Author :
language : en
Publisher:
Release Date : 1965
Family Planning News written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1965 with Birth control categories.