Modern Tools For The Synthesis Of Complex Bioactive Molecules
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Modern Tools For The Synthesis Of Complex Bioactive Molecules
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Author : Janine Cossy
language : en
Publisher: John Wiley & Sons
Release Date : 2012-09-04
Modern Tools For The Synthesis Of Complex Bioactive Molecules written by Janine Cossy and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-04 with Science categories.
All the latest tools needed to plan and perform the synthesisof complex bioactive molecules Focusing on organic, organometallic, and bio-oriented processes,this book explores the impact and use of the latest synthetic toolsfor the synthesis of complex biologically active compounds. Readerswill discover step by step how these synthetic tools have providednew, elegant solutions to many synthetic puzzles. Moreover, theywill discover innovative methods that make it possible to controlthe exact connectivity of atoms within a molecule in order to setprecise three-dimensional arrangements. Modern Tools for the Synthesis of Complex BioactiveMolecules features sixteen chapters, each one written by one ormore leading experts in organic synthesis from around the world. Itcovers a broad range of topics that enable readers to takeadvantage of the latest methods for synthesizing complex molecules,including: Modern catalysis, emphasizing key transformations such as C-Hfunctionalizations, cross-couplings, gold-catalyzed reactions,metathesis-based syntheses, and asymmetric organocatalysis Eco-compatible transformations, including rearrangements anddomino reactions Tools for the synthesis of carbohydrates and alkaloids New techniques, including the use of fluorous tags andengineered biosynthesis The last two chapters explore target- and diversity-orientedorganic synthesis as well as the use of DNA-based asymmetriccatalysis, which are all promising tools for the successfulsynthesis of complex bioactive molecules. Modern Tools for the Synthesis of Complex BioactiveMolecules is ideal for students and researchers who need toplan and perform the synthesis of complex molecules as efficientlyas possible. The book's expert advice will help these readersquickly resolve a broad range of problems that can arise in organicsyntheses.
Cutting Edge Organic Synthesis And Chemical Biology Of Bioactive Molecules
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Author : Yuichi Kobayashi
language : en
Publisher: Springer
Release Date : 2019-05-30
Cutting Edge Organic Synthesis And Chemical Biology Of Bioactive Molecules written by Yuichi Kobayashi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-30 with Science categories.
This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.
Structure Based Design Of Drugs And Other Bioactive Molecules
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Author : Arun K. Ghosh
language : en
Publisher: John Wiley & Sons
Release Date : 2014-08-11
Structure Based Design Of Drugs And Other Bioactive Molecules written by Arun K. Ghosh and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-11 with Medical categories.
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.
Mechanochemistry
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Author : Evelina Colacino
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2020-12-07
Mechanochemistry written by Evelina Colacino and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-07 with Technology & Engineering categories.
Mechanochemistry has been recently ackwnoledged by IUPAC as one of the top ten emerging technologies in chemistry, answering to the increased demand for clean processes and sustainable reaction conditions. This book focuses on the rediscovery of mechanochemistry for inorganic, organic and organo-metallic materials. Focus on experimental techniques and equipment will show how to implement mechanochemistry as an innovative way to sustainability in academic laboratories. The contents are ideal for researchers starting off in industry and academia, as well as advanced students.
Advances In Heterocyclic Chemistry
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Author :
language : en
Publisher: Academic Press
Release Date : 2015-08-12
Advances In Heterocyclic Chemistry written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-12 with Science categories.
Advances in Heterocyclic Chemistry is the definitive series in the field—one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists, and many biological scientists Provides the latest comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds
Flow Chemistry Applications
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Author : Ferenc Darvas
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2021-10-25
Flow Chemistry Applications written by Ferenc Darvas and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-25 with Technology & Engineering categories.
The fully up-dated edition of the two-volume work covers both the theoretical foundation as well as the practical aspects. A strong insight in driving a chemical reaction is crucial for a deeper understanding of new potential technologies. New procedures for warranty of safety and green principles are discussed. Vol. 1: Fundamentals.
From Biosynthesis To Total Synthesis
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Author : Alexandros L. Zografos
language : en
Publisher: John Wiley & Sons
Release Date : 2016-03-17
From Biosynthesis To Total Synthesis written by Alexandros L. Zografos and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-17 with Science categories.
Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
Handbook Of Reagents For Organic Synthesis
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Author : André B. Charette
language : en
Publisher: John Wiley & Sons
Release Date : 2015-07-15
Handbook Of Reagents For Organic Synthesis written by André B. Charette and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-15 with Science categories.
Heteroarenes are among the most prevalent structural units in natural products, pharmaceuticals, agrochemicals, and other compounds of scientific or commercial interest. In the last decade, a broad range of novel synthetic methods has been developed to not only facilitate construction of the heteroarene motif, but to enable its modification through direct C–H functionalization. This Handbook describes 117 key reagents for selective heteroarene functionalization reactions, including both traditional and transition metal-catalyzed C–H functionalization. Since these reactions typically involve one heteroarene, a coupling partner and a catalyst, the handbook not only focuses on the catalyst itself but also contains other key reaction species. All the information compiled in this volume is also available in electronic format on Wiley Online Library. The 117 reagents represented here are but a small fraction of the ca. 5,000 reagents available in the electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS). e-EROS offers various search interfaces to locate reagents of interest, including chemical structure, substructure and reactions search modes. e-EROS is updated regularly with new and updated entries.
Efficiency In Natural Product Total Synthesis
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Author : Pei-Qiang Huang
language : en
Publisher: John Wiley & Sons
Release Date : 2018-07-24
Efficiency In Natural Product Total Synthesis written by Pei-Qiang Huang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-24 with Science categories.
Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals
The Chemistry Of Organogold Compounds 2 Volume Set
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Author : Zvi Rappoport
language : en
Publisher: John Wiley & Sons
Release Date : 2015-04-20
The Chemistry Of Organogold Compounds 2 Volume Set written by Zvi Rappoport and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-20 with Science categories.
The first book in the PATAI Series was published in 1964 and the Series will celebrate its 50th Anniversary in 2014. This "Golden Jubilee" is accompanied by the publication of the first volume on the chemistry of organogold. In the history of the PATAI Series there was, so far, no volume dedicated to gold alone. In 1999 we published a volume on The Chemistry of Gold and Silver Compounds. Since then a lot of new chemistry using gold has been developed and it is timely to focus a volume on methods and applications of organogold compounds in organic synthesis, reflecting the enormous progress which has been made in the use of gold compounds as reagents and catalysts. A second area of great importance covered in the book is the use of gold surfaces in the synthesis of peptides, proteins and other natural products. A whole range of applications in the area of biochemistry has resulted from these developments. A third area of interest is the synthesis and engineering of nanostructures, where organogold chemistry has opened the door for a wide range of methods and applications in the field of nanoscience and materials science. As with all new volumes, the chapters are first published online in Patai's Chemistry of Functional Groups. Once a volume is completed online, it is then published in print format. The printed book offers the traditional quality of the Patai Book Series, complete with an extensive index.