Modulation Of Cellular Responses In Toxicity
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Modulation Of Cellular Responses In Toxicity
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Author : Corrado L. Galli
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Modulation Of Cellular Responses In Toxicity written by Corrado L. Galli and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
Proceedings of the NATO Advanced Study Institute on the Modulation of Cellular Response in Toxicity, held in Ponte di Legno, Italy , January 24 - February 3, 1994.
Advances In Molecular Toxicology
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Author : Claude Reiss
language : en
Publisher: VSP
Release Date : 1998-02
Advances In Molecular Toxicology written by Claude Reiss and has been published by VSP this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-02 with Science categories.
Molecular toxicology is on the way to setting a new standard in toxic risk assessment, with the powerful help of concepts and methods developed in the fields of molecular and cellular biology. The methods of molecular toxicology are endowed with qualities not always secured in more traditional approaches to toxicity assessment. These methods are easily standardized, reliable, reproducible and require only tiny amounts of the xenobiotic. They are much simpler, faster and less costly than current tests on animals and can be implemented with modest laboratory resources. This volume of Advances in Molecular Toxicology represents a collection of invited papers presented at the First European Workshop on Molecular Toxicology in Sophia Antipolis, France, The book covers 8 selected topics in molecular toxicology. The first two are devoted to ''physics'', dealing respectively with advanced instrumentation enabling location and quantification of xenobiotics in cells and organs with ultimate precision, and computer-assisted assessment of risk (QSAR). A comprehensive and up-to-date survey of molecular toxicology in the pharmaceutical industry is contributed by a pioneer in this field. The third section addresses the effect of xenobiotics on cell-cycle actors. Sections 4--6 deal with molecular toxicology in skin, kidney, nerve, liver and pancreatic cells. The last two sections describe methods to probe DNA damage and repair, and immunotoxicity.
Information Resources In Toxicology
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Author : Philip Wexler
language : en
Publisher: Academic Press
Release Date : 2000
Information Resources In Toxicology written by Philip Wexler and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...
Approaches To High Throughput Toxicity Screening
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Author : C. K. Atterwill
language : en
Publisher: CRC Press
Release Date : 1999-12-16
Approaches To High Throughput Toxicity Screening written by C. K. Atterwill and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-16 with Medical categories.
An integrated approach to in vitro toxicology and ADME screening using new technologies and discussing how they might be applied to the safety assessment of new pharamceutical products in drug discovery.
Plant Responses To Cadmium Toxicity
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Author : Tariq Aftab
language : en
Publisher: Springer Nature
Release Date : 2024-12-19
Plant Responses To Cadmium Toxicity written by Tariq Aftab and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-19 with Science categories.
This book offers an exploration of how plants respond to the presence of cadmium, shedding light on both the physiological and molecular mechanisms In an era of growing environmental concern, this edited book serves as an invaluable resource, shedding light on the intricate interplay between plants and cadmium, a menacing environmental pollutant. Cadmium's pervasive presence in the soil poses a significant threat to plant ecosystems, impacting food security and human well-being. This comprehensive book explores the multifaceted responses of plants to cadmium toxicity, offering critical insights into the physiological and molecular mechanisms governing these reactions. The edited book delves into the intricate relationship between plants and cadmium, a highly toxic heavy metal. Cadmium contamination in the environment, largely stemming from industrial processes and agricultural practices, poses a significant threat to plant ecosystems and, by extension, human and environmental health. This book offers a comprehensive exploration of how plants respond to the presence of cadmium, shedding light on both the physiological and molecular mechanisms that govern these responses. Written by leading experts in the field, this book provides a holistic understanding of the challenges posed by cadmium contamination and the innovative strategies plants employ to combat its detrimental effects. It encompasses a wide array of topics, from the physiological changes plants undergo under cadmium stress to the genetic and molecular pathways activated in response. Furthermore, it explores the practical potential of phytoremediation, a sustainable approach that harnesses plants' abilities to detoxify contaminated environments. This book is a valuable resource for researchers, scholars, and students in the fields of plant biology, environmental science, and toxicology, offering a deep understanding of the challenges presented by cadmiumcontamination and the innovative strategies that plants employ to adapt and thrive in the face of adversity. With a focus on both fundamental science and practical applications, this edited book offers a comprehensive perspective on a critical issue in modern agriculture, environmental science, and plant biology.
Adrenal In Toxicology
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Author : Philip W. Harvey
language : en
Publisher: CRC Press
Release Date : 1996-03-28
Adrenal In Toxicology written by Philip W. Harvey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-03-28 with Medical categories.
The adrenal gland is vitally important to health and secretes hormones that control many bodily processes ranging from normal metabolism to the response to stressful circumstances. The corticosteroid hormones are the basis for anti-inflammatory medicines and are very widely prescribed. Changes in the function of the adrenal gland, either naturally through stress or disease, or through the action of drugs and chemicals, can have a major impact on the body.; This text focuses on adrenal toxicity, examining how drugs and chemicals can directly and indirectly affect this gland. Coverage includes: classification of the types of adrenal and endocrine toxicity; the mechanistic and molecular basis of toxicity; reasons why the adrenal is the most common target organ in the endocrine system; drug toxicity specific to patients with adrenal disorders; drug- corticosteroid interactions; adverse drug reactions; and how the adrenal gland is vital in tolerance to toxic insult.
Quantitative Modeling In Toxicology
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Author : Kannan Krishnan
language : en
Publisher: John Wiley & Sons
Release Date : 2010-04-01
Quantitative Modeling In Toxicology written by Kannan Krishnan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-01 with Science categories.
Governments around the world are passing laws requiring industry to assess the toxicity of the chemicals and products they produce, but to do so while reducing, refining, or even replacing testing on animals. To meet these requirements, experimental toxicologists and risk assessors are adopting quantitative approaches and computer simulations to study the biological fate and effects of chemicals and drugs. In Quantitative Modeling in Toxicology leading experts outline the current state of knowledge on the modeling of dose, tissue interactions and tissue responses. Each chapter describes the mathematical foundation, parameter estimation, challenges and perspectives for development, along with the presentation of a modeling template. Additionally, tools and approaches for conducting uncertainty, sensitivity and variability analyses in these models are described. Topics covered include: the quantitative models of pharmacokinetics of individual chemicals and mixtures models for toxicant-target tissue interaction. models for cellular, organ, and organism responses. approaches, tools and challenges for model application and evaluation A website containing computer codes accompanies the book to help the reader reconstruct the models described and discussed in the various chapters. Quantitative Modeling in Toxicology serves as an essential reference source and tool box for risk assessors and researchers and students in toxicology, public health, pharmacology, and human toxicology interested in developing quantitative models for a better understanding of dose-response relationships.
Organ Directed Toxicities Of Anticancer Drugs
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Author : Miles P. Hacker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Organ Directed Toxicities Of Anticancer Drugs written by Miles P. Hacker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in tervention. Much of this toxicity, such as damage to the bone marrow, gastroin testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively dividing cells. These types of toxicities, while serious, are usually manageable and reversible and are, therefore, not often considered to be dose limiting. Unfortunately, several of the most important anticancer drugs also damage tissues in which the growth fraction is relatively small. Such toxicities can not be predicted based on the chemical structure of the drugs, are often not detected in preclinical studies, and are encountered frequently for the first time in clinical studies. Further, unlike most of the proliferative-dependent toxicities, the unpre dicted toxicities are usually irreversible or only partially reversible upon cessation of drug administration. Because of this, the unpredicted toxicities are referred to as dose limiting. They represent a significant barrier to the ultimate efficacy of several of our most important anticancer drugs.
Nrf2 And Its Modulation In Inflammation
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Author : Huai Deng
language : en
Publisher: Springer Nature
Release Date : 2020-05-21
Nrf2 And Its Modulation In Inflammation written by Huai Deng and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-21 with Medical categories.
Nrf2, a transcription factor that mediates transcriptional responses to oxidative and xenobiotic stresses, plays a central role in cellular protection against internal or external toxins. Defects in Nrf2 and the relevant regulatory pathways are associated with a number of pathologies including inflammation, respiratory diseases, cardiovascular dysfunctions, metabolic syndrome and diabetes, neurodegeneration, and cancer. This book comprehensively reviews the up-to-date discoveries for the roles of Nrf2 in several human diseases in the context of inflammation. In particular, the molecular mechanisms that mediate the functions of Nrf2 and its interacting network in inflammation and pathogenesis are explicated. In addition, the research and therapeutic applications of Nrf2-targeting compounds in different diseases were summarized. This book is expected to be a valuable reference for worldwide researchers conducting both mechanistic and therapeutic studies of Nrf2 and relevant factors.
Toxicology Research Projects Directory
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Author :
language : en
Publisher:
Release Date : 1980-10
Toxicology Research Projects Directory written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980-10 with Toxicology categories.