Modulation Of Oxidative Stress In Heart Disease
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Modulation Of Oxidative Stress In Heart Disease
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Author : Sajal Chakraborti
language : en
Publisher: Springer Nature
Release Date : 2019-11-10
Modulation Of Oxidative Stress In Heart Disease written by Sajal Chakraborti and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-10 with Science categories.
This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.
Oxidative Stress In Heart Diseases
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Author : Sajal Chakraborti
language : en
Publisher: Springer Nature
Release Date : 2019-11-06
Oxidative Stress In Heart Diseases written by Sajal Chakraborti and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-06 with Science categories.
This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.
Mechanisms And Modulation Of Oxidative Stress
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Author : Emmett Allison
language : en
Publisher: States Academic Press
Release Date : 2023-09-26
Mechanisms And Modulation Of Oxidative Stress written by Emmett Allison and has been published by States Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Science categories.
Oxidative stress refers to a condition caused by an imbalance between the systemic expression of reactive oxygen species (ROS) and the ability of a biological system to quickly detoxify the reactive intermediates or repair the harm. Strand breaks in DNA and base damage are caused by oxidative stress. It can interrupt normal mechanisms of cellular signaling and has been linked to the development of a number of diseases such as cancer, cardiovascular diseases and neurodegenerative diseases. Modulation of oxidative stress is done specifically through the regulation of gene transcription, such as the activation or inhibition of Nrf2. It is regarded as an important strategy for developing new drugs for some of the pathologies, including neoplastic and cardiovascular diseases, that are resistant to other treatments. This book provides significant information to help develop a good understanding of oxidative stress mechanisms and modulation. It presents researches and studies performed by experts across the globe. The extensive content of this book provides the readers with a thorough understanding of this subject.
Oxidative Stress And Vascular Disease
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Author : John F. Keaney Jr.
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Oxidative Stress And Vascular Disease written by John F. Keaney Jr. and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.
Blood Oxidant Ties The Evolving Concepts In Myocardial Injury And Cardiovascular Disease
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Author : Bashir Matata
language : en
Publisher: Bentham Science Publishers
Release Date : 2023-07-18
Blood Oxidant Ties The Evolving Concepts In Myocardial Injury And Cardiovascular Disease written by Bashir Matata and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-18 with Health & Fitness categories.
Blood Oxidant Ties: The Evolving Concepts in Myocardial Injury and Cardiovascular Disease is an update on the recent advances in the development of antioxidant-based therapies. It starts with an overview of the mechanisms underlying the genesis of oxidative stress, summarizing the link between oxidative stress and a number of cardiovascular conditions. This is followed by an explanation of how oxidative stress interacts with lipid metabolism and the placental environment. Three chapters on the role of antioxidant-based therapy for cardiovascular diseases round up the book. Key Features - Outlines several cell-signaling pathways that are modulated by the interplay between reducing and oxidizing agents (redox status) and gene expression in the cardiovascular disease process - Brings information about maternal programming environment in the placenta - Covers development of novel nanotechnology-based antioxidant delivery systems for effective drug delivery - Includes references for further reading The book is aimed at a broad readership of scientific and medical professionals involved in research on cardiovascular diseases, pathophysiology, pharmacy, pharmaceutical science and life sciences. It also serves as a reference for scholars who want to understand the complex biochemical mechanisms of antioxidant agents.
Modulators Of Oxidative Stress
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Author : Hande Gurer-Orhan
language : en
Publisher: MDPI
Release Date : 2020-11-03
Modulators Of Oxidative Stress written by Hande Gurer-Orhan and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-03 with Science categories.
The book starts with the editors' preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.
Current Advances For Development Of Functional Foods Modulating Inflammation And Oxidative Stress
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Author : Blanca Hernandez-Ledesma
language : en
Publisher: Academic Press
Release Date : 2021-12-03
Current Advances For Development Of Functional Foods Modulating Inflammation And Oxidative Stress written by Blanca Hernandez-Ledesma and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-03 with Technology & Engineering categories.
Current Advances for Development of Functional Foods Modulating Inflammation and Oxidative Stress presents the nutritional and technological aspects related to the development of functional foods with anti-inflammatory and antioxidant effects. Specifically, analytical approaches for the characterization of anti-inflammatory and antioxidant properties of healthy foods and functional constituents, as well as technological strategies for the extraction of compounds and fractions from raw materials to produce anti-inflammatory and antioxidant ingredients are addressed. In addition, the molecular mechanisms by which foods and their components can modulate inflammation and their oxidative stress effects on disease prevention are explored. Finally, clinical research addressing nutritional needs in pathological subjects with inflammatory diseases are considered. Covers methods of analysis and extraction of anti-inflammatory and antioxidant compounds Offers an overview of the main anti-inflammatory and antioxidant compounds in foods Provides a guide on the mechanisms of action and health benefits of anti-inflammatory and antioxidant dietary bioactives
Modulation Of Oxidative Stress
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Author : Luciano Saso
language : en
Publisher: Elsevier
Release Date : 2023-08-01
Modulation Of Oxidative Stress written by Luciano Saso and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-01 with Medical categories.
Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out. Provides the latest updates in the fast-developing field of REDOX biochemistry and pharmacology Presents content that is clear and easy to read Useful for researchers and instructors in many fields
Molecular And Cellular Effects Of Nutrition On Disease Processes
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Author : Grant N. Pierce
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Molecular And Cellular Effects Of Nutrition On Disease Processes written by Grant N. Pierce and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.
This volume contains the proceedings of the 2nd World Conference of the International Society for Molecular Nutrition & Therapy. This conference was held on August 2-4, 1997, in Winnipeg, Canada. The goal of the conference was to advance our knowledge concerning the molecular events which link nutrition to various disease processes in the body. This volume represents an important compilation of unique articles addressing the molecular and cellular basis for the nutritional and therapeutic treatment of five general disease processes.
Oxidative Stress In Microbial Diseases
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Author : Sajal Chakraborti
language : en
Publisher: Springer
Release Date : 2019-11-12
Oxidative Stress In Microbial Diseases written by Sajal Chakraborti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-12 with Science categories.
This book discusses recent advances in our understanding of the role of oxidants in microbial pathophysiology, providing valuable insights into the complex role of reactive oxygen species (ROS) in host-microbial interactions. The various chapters take readers through the function of ROS in infections ranging from viral to bacterial, and describe how microorganisms have developed complex strategies to not only avoid contact with phagocyte-derived oxidants, but also protect themselves from injury when oxidants are encountered. Featuring the latest research in the field of microbial diseases, this timely book is a ready reference for scientists looking to develop new anti-microbial drugs.