Modulation Of T Cell Function And Survival By The Tumor Microenvironment
DOWNLOAD
Download Modulation Of T Cell Function And Survival By The Tumor Microenvironment PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Modulation Of T Cell Function And Survival By The Tumor Microenvironment book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Modulation Of T Cell Function And Survival By The Tumor Microenvironment
DOWNLOAD
Author : Shahrzad Jalali
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-26
Modulation Of T Cell Function And Survival By The Tumor Microenvironment written by Shahrzad Jalali and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Science categories.
Manipulating The Immunological Tumor Microenvironment
DOWNLOAD
Author : Peng Qu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-31
Manipulating The Immunological Tumor Microenvironment written by Peng Qu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-31 with Medical categories.
Immunologic Tumor Microenvironment Modulators For Turning Cold Tumors To Hot Tumors
DOWNLOAD
Author : Xin He
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-24
Immunologic Tumor Microenvironment Modulators For Turning Cold Tumors To Hot Tumors written by Xin He and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-24 with Medical categories.
Cancer immunotherapy is based on using the immune system components to fight tumors, without destroying normal cells. Several immunotherapeutic strategies have been investigated and proposed for the treatment of cancers, including cancer vaccines containing tumor antigens that are used to induce immune responses against tumors, monoclonal antibodies against tumor antigens, and immune checkpoint inhibitors. However, many clinical trials have shown that the use of these methods as monotherapy is ineffective in many cases. Many tumors can resist immunotherapy due to the absence or insufficient infiltration of tumors with CD8+ T cells and hence, are called “cold” or non-inflammatory tumors. Cold tumors are characterized by a lack of infiltrating CD8+ T cells, the presence of anti-inflammatory myeloid cells, tumor-associated M2 macrophages, and regulatory T cells. A combination of other cancer therapeutic approaches, such as chemotherapy or immunotherapy with cancer vaccines, could dramatically enhance the efficacy and, eventually, the outcome of the treatment. Despite some success of the immunotherapy of oncological diseases, cold tumors represent one of the main therapeutic challenges for modern immunotherapy. It can be expected that in the near future, treatment algorithms will be developed to adapt the therapeutic strategies to the immune context of the tumor since treatment with checkpoint inhibitors or vaccines alone is not enough for cold tumors. Therefore, using other therapeutic approaches alongside the existing treatment methods can be more reasonable for cold tumors that do not strongly stimulate the immune system or resist against it. To apply targeted treatments such as the use of small molecules, small peptides, hybrid small molecules, biologically active peptides, non-protein isolates of food products or by-products, and every material that is capable of the disturbing immunosuppressive tumor microenvironment (TME) as an adjuvant therapy can reduce the resistance of cold tumors to immunotherapy which is so-called turning them into “warm” tumors. This research topic aims to cover all outstanding advances in immunology, medical chemistry and biochemistry, pharmacology, food engineering and molecular biology of contemporary molecular drug targets involved in cancer treatment and encompasses the following subjects: • Definition and explanation of cold tumors and challenges ahead toward their treatment • Designing and application of small peptides, small molecules, and other similar materials to overcome suppressive TME and break tumors resistance • Extraction and preparation of bioactive peptides or other components derived from natural resources to make cold tumor barriers fragile • Modifications and alterations leading to overcoming cold tumor resistance against cancer vaccines and ICP inhibitors Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Aacr 2017 Proceedings Abstracts 3063 5947
DOWNLOAD
Author : American Association for Cancer Research
language : en
Publisher: CTI Meeting Technology
Release Date : 2017-03-13
Aacr 2017 Proceedings Abstracts 3063 5947 written by American Association for Cancer Research and has been published by CTI Meeting Technology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-13 with Medical categories.
Enhancing T Cell Function Innovations In Cancer Immunotherapy
DOWNLOAD
Author : Xuefeng Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-05-22
Enhancing T Cell Function Innovations In Cancer Immunotherapy written by Xuefeng Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-22 with Medical categories.
Cancer immunotherapy has been revolutionized by targeting specific immune subsets within the tumor microenvironment, where T cells play a pivotal role. Gene-engineered T cell strategies and immune checkpoint blockade (ICB) therapies have emerged as powerful approaches to reinvigorate tumor-infiltrating T cells, demonstrating considerable promise in clinical outcomes. However, challenges persist, particularly the limited in vivo persistence of adoptively transferred T cells and the variable patient response rates to ICB therapy. Key barriers include T cell exhaustion and the immunosuppressive milieu of the tumor microenvironment. Consequently, a deep understanding of functional modulation of these immune subsets is urgently needed to enhance the efficacy and safety of various T cell therapies, such as Tumor-infiltrating T lymphocytes (TIL-T), T cell receptor-engineered T cells (TCR-T), and Chimeric antigen receptor T cells (CAR-T). This Research Topic aims to explore and identify crucial targets and pathways for overcoming immune dysregulation in the tumor microenvironment. We seek to advance our understanding of these complexities by discussing innovative techniques that could augment T cell antitumor functionality. Contributions that unveil novel approaches or refine existing methods to boost the therapeutic potential of T cells in cancer treatment are particularly encouraged.
Multidisciplinary Research In Arts Science Commerce Volume 15
DOWNLOAD
Author : Chief Editor- Biplab Auddya, Editor- Dr. Bijikumary P, Dr. Pravin Vivek Kaslikar, Prof. Rohit Kulkarni, Mr. Enock I, Dr. J.Sathish Kumar, Dr. Balaji Shivraj Hokarne
language : en
Publisher: The Hill Publication
Release Date : 2024-12-19
Multidisciplinary Research In Arts Science Commerce Volume 15 written by Chief Editor- Biplab Auddya, Editor- Dr. Bijikumary P, Dr. Pravin Vivek Kaslikar, Prof. Rohit Kulkarni, Mr. Enock I, Dr. J.Sathish Kumar, Dr. Balaji Shivraj Hokarne and has been published by The Hill Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-19 with Antiques & Collectibles categories.
Implications Of Immune Landscape In Tumor Microenvironment
DOWNLOAD
Author : Selvarangan Ponnazhagan
language : en
Publisher: Frontiers Media SA
Release Date : 2024-10-01
Implications Of Immune Landscape In Tumor Microenvironment written by Selvarangan Ponnazhagan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-01 with Medical categories.
Tumor microenvironment (TME) plays an important role in immunosuppressive mechanisms that result in immune editing and treatment resistance. Elucidating the diversity of stromal and immune cell distribution, polarization, and changes in their gene expression signatures will enable a better understanding of key events to improve treatment and prognosis. With the onset of immune checkpoint inhibitors (ICIs) in clinics for patients with solid tumors and hematologic malignancies, immunotherapy has taken a new direction in cancer management, especially as combination therapies. However, limitations encountered with the use of ICIs, including toxicity and immune-related adverse events (irAE) indicate the need to understand multiple regulatory mechanisms at both cellular and molecular levels that alter the immune landscape of the TME. Since predominant changes in the immune landscape occur at the TME, focussed deliberation on these events will provide a comprehensive understanding on this topic for scientists in the fields of basic, translational, and clinical cancer immunology. The heterogeneity of TME and complex immune landscape pose major challenges in the treatment of solid tumors. Thus, integrative approaches, which relate immune mechanisms in the TME to that of peripheral and systemic immune signatures are essential to improve our understanding of the disease complexity and possibly improve immunotherapy outcomes. Such multiparametric studies should combine advances in current understanding of cancer immunobiology with powerful technologies, such as single-cell and spatial transcriptomics, and high dimensional flow cytometry that rapidly expand our ability to explore these interactions. Notably, tumor heterogeneity and inflammatory mediators in the TME vary significantly in neoplasms based on mutational load, lymphocyte infiltration, expression of checkpoint molecules, soluble inhibitors, and tumor cell metabolism. Overall, connecting key events to immune signatures that conform to a consensus will provide a benchmark to delve further into this important topic. Other parameters such as myeloid and lymphoid cell polarization to alter the immune homeostasis at the TME, favoring a tumor-supportive milieu would provide a macroscopic picture that may help guide treatment choices for more refined personalized tumor immunotherapy.
Car T Cell Therapies For Non Hematopoietic Malignancies Taking Off The Training Wheels
DOWNLOAD
Author : Avery Dexter Posey, Jr.
language : en
Publisher: Frontiers Media SA
Release Date : 2020-04-24
Car T Cell Therapies For Non Hematopoietic Malignancies Taking Off The Training Wheels written by Avery Dexter Posey, Jr. and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-24 with categories.
Chimeric antigen receptor (CAR) T cell therapies for leukemia (e.g. tisagenlecleucel) and lymphoma (e.g. axicabtagene ciloleucel) have recently received regulatory approval in the United States. Phase I/II trials have demonstrated complete remission of refractory or relapsed tumors in 50% - 94% patients. However, the clinical successes of engineered T cells for the treatment of solid malignancies have thus far been few and far between. Furthermore, several instances of severe and lethal toxicities have arisen due to on-target, off-tumor recognition of antigen by T cell products. Recent advances in phase I trials for solid tumors, as well as in pre-clinical models, have revealed several variables that will be important to consider for the successful use of CAR-T cells in treating solid tumors. These variables include (i) regional versus systemic delivery; (ii) scFv versus ligand interactions; (iii) antigen loss versus escape; (iv) epitope spreading and (v) checkpoint expression on immune cells or tumor cells. Also, there remains outstanding mechanistic questions related to why differences exist in the persistence and tonic signaling of second-generation CD28 versus 4-1BB co-stimulated CAR-T cells. In addition, we are now learning the roles of lympho-depleting regimens (and associated toxicities) in modifying the persistence of engineered T cell therapies. A more comprehensive view of CAR-T cell strategies and important advances, both of pre-clinical and clinical evaluations, in solid tumors is necessary to drive these therapies forward.
Immune Therapy For Pancreatic And Colon Cancers
DOWNLOAD
Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Elsevier
Release Date : 2024-11-26
Immune Therapy For Pancreatic And Colon Cancers written by Ganji Purnachandra Nagaraju and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-26 with Science categories.
Immune Therapy for Pancreatic and Colon Cancer expands the knowledge on pathways, immune modulators, immune check points, and monoclonal antibodies that can lead to appropriate cancer treatment. With a strong focus on the development of immune therapies to improve the survival rates of pancreatic and colon cancer, this book also shows the latest trends in immune targeted approaches for cancer treatment. Sections describe the role of and the immune response to pancreatic and colon cancer, gives insights to past and current immunotherapies, including metabolic reprogramming, immune blockade therapy and immune modulation.This book is a valuable resource for health professionals, scientists and researchers, students, and all those who wish to broaden their knowledge of the advances in immunotherapy in pancreatic and colon cancer, inspire them and guide their design of novel experimental projects and translational studies. - Aims to incorporate diverse and novel immunotherapeutic strategies, targeting a wide array of tumor-induced immune escape mechanisms - Elucidates both past and current differences in immunotherapies, while also including strategies based on monoclonal antibodies' vaccine, and oncolytic virus-related immunotherapies - Provides an updated understanding of the how resistance breaks with immunotherapy in both pancreatic and colon cancer
Modulation Of Human Immune Parameters By Anticancer Therapies
DOWNLOAD
Author : Ulrich Sack
language : en
Publisher: Frontiers Media SA
Release Date : 2021-01-18
Modulation Of Human Immune Parameters By Anticancer Therapies written by Ulrich Sack and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-18 with Medical categories.