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Molecular Analysis Of Cancer


Molecular Analysis Of Cancer
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Molecular Analysis Of Cancer


Molecular Analysis Of Cancer
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Author : Jacqueline Boultwood
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02

Molecular Analysis Of Cancer written by Jacqueline Boultwood and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Medical categories.


Over the past 20 years, technological advances in molecular biology have proven invaluable to the understanding of the pathogenesis of human cancer. The application of molecular technology to the study of cancer has not only led to advances in tumor diagnosis, but has also provided markers for the assessment of prognosis and disease progression. The aim of Molecular Ana- sis of Cancer is to provide a comprehensive collection of the most up-to-date techniques for the detection of molecular changes in human cancer. Leading researchers in the field have contributed chapters detailing practical pro- dures for a wide range of state-of-the-art techniques. Molecular Analysis of Cancer includes chapters describing techniques for the identification of chromosomal abnormalities and comprising: fluor- cent in situ hybridization (FISH), spectral karyotyping (SKY), comparative genomic hybridization (CGH), and microsatellite analysis. FISH has a pro- nent role in the molecular analysis of cancer and can be used for the detection of numerical and structural chromosomal abnormalities. The recently described SKY, in which all human metaphase chromosomes are visualized in specific colors, allows for the definition of all chromosomal rearrangements and marker chromosomes in a tumor cell. Protocols for the detection of chromosomal re- rangements by PCR and RT-PCR are described, as well as the technique of DNA fingerprinting, a powerful tool for studying somatic genetic alterations in tumorigenesis.



Genetic Modeling Of Cancer


Genetic Modeling Of Cancer
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Author : Anna Walentinsson
language : en
Publisher:
Release Date : 2001

Genetic Modeling Of Cancer written by Anna Walentinsson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Gene amplification categories.




Molecular Biology Of The Cell


Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002

Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.




Molecular Biology Of Cancer


Molecular Biology Of Cancer
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Author : Fiona Macdonald
language : en
Publisher: Garland Science
Release Date : 2004-01-15

Molecular Biology Of Cancer written by Fiona Macdonald and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-15 with Science categories.


Molecular Biology of Cancer has been extensively revised and covers heredity cancer, microarray technology and increased study of childhood cancers. It continues to provide a detailed overview of the process which lead to the development and proliferation of cancer cells, including the techniques available for their study. It also describes the means by which tumor suppressor genes and oncogenes may be used in the diagnosis and in determining the prognosis of a wide variety of cancers, including breast, genitourinary, lung and gastrointestinal cancer.



Molecular Analysis Of Ltfr And Yap Genes In Breast Cancer Patients


Molecular Analysis Of Ltfr And Yap Genes In Breast Cancer Patients
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Author : Real Sumayya Abdul Sattar
language : en
Publisher: Mohammed Abdul Sattar
Release Date : 2024-02-21

Molecular Analysis Of Ltfr And Yap Genes In Breast Cancer Patients written by Real Sumayya Abdul Sattar and has been published by Mohammed Abdul Sattar this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-21 with Medical categories.


Breast cancer accounts for 25% of the world cancers and is the most frequent cancer among women. Less developed regions had 883,000 breast cancer cases whereas more developed regions had 794,000 breast cancer cases. It is second most prevalent cancer and ranks fifth with respect to overall cancer related mortality, with a prediction of increase in new cases upto 22 million in two decades. Long-time fertility, use of oral contraceptives, nulliparity, obesity post menopause, hormone replacement therapy, various genetical, environmental and life style factors are some of the important risk factors reported. Various signaling pathways are interconnected during breast carcinogenesis. Hippo signaling actively participates in the normal mammary gland development and is an emerging tumor suppressor pathway. Deregulation of Hippo signaling leads to mammary gland malignancy. A considerable percentage of human breast cancers may be transformed due to the deregulation of Leukemia inhibitory factor receptor (LIFR). LIFR, also known as glycoprotein-190 (gp 190), is a novel tumor suppressor and belongs to the large family of the hematopoietin receptors. A variety of hematopoietic and epithelial cells has been identified for the presence of LIFR. Leukemia inhibitory factor (LIF) is a pluripotent cytokine with heterogeneous effects on hematopoietic and epithelial cells. The effects can be growth-stimulatory or growth-inhibitory based on the nature of the target cell. Several human malignancies have shown the involvement of LIFR including medulloblastoma, nasopharyngeal carcinoma, liver, lung, and breast cancer.



Cancer Genomics


Cancer Genomics
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Author : Anna Gustafsson
language : en
Publisher:
Release Date : 2004

Cancer Genomics written by Anna Gustafsson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.




Inflammation And Cancer


Inflammation And Cancer
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Author :
language : en
Publisher:
Release Date : 2009

Inflammation And Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.




Molecular Analysis Of Circulating Cell Free Dna In Lung Cancer


Molecular Analysis Of Circulating Cell Free Dna In Lung Cancer
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Author : Ricky Mark Trigg
language : en
Publisher:
Release Date : 2017

Molecular Analysis Of Circulating Cell Free Dna In Lung Cancer written by Ricky Mark Trigg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.




Modern Molecular Biology


Modern Molecular Biology
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Author : Srinivasan Yegnasubramanian
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-02

Modern Molecular Biology written by Srinivasan Yegnasubramanian and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-02 with Medical categories.


Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to these macromolecules that occur in diseases such as cancer. In this volume, we will explore the modern approaches used to characterize these macromolecules in an unbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly interpreted by biostatistical/bioinformatics analyses, can be exploited for the prevention, diagnosis, and treatment of human cancers. The purpose of this volume is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research. Advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression will be overviewed. These include the strategies employed in modern genomics, gene expression analysis, and proteomics.



Inflammation And Cancer


Inflammation And Cancer
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Author : Serguei V. Kozlov
language : en
Publisher: Humana Press
Release Date : 2009-05-26

Inflammation And Cancer written by Serguei V. Kozlov and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-26 with Medical categories.


According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Protocols, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 2, Molecular Analysis and Pathways is devoted to an extensive description of experimental strategies aimed at investigating the molecular cross-talks between components of cell signaling chains and their ramifications in diagnostic development and drug target discovery. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory protocols, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Inflammation and Cancer: Methods and Protocols promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of combatting the estimated 2, 200 inflammation-related oncogenesis fatalities occurring every day.