Molecular And Cellular Mechanisms Of Alcohol And Anesthetics
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Molecular And Cellular Mechanisms Of Alcohol And Anesthetics
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Author : Emanuel Rubin
language : en
Publisher:
Release Date : 1991
Molecular And Cellular Mechanisms Of Alcohol And Anesthetics written by Emanuel Rubin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Alcohol categories.
Molecular And Cellular Mechanisms Of Alcohol And Anesthetics
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Author : Emanuel Rubin
language : en
Publisher:
Release Date : 1991
Molecular And Cellular Mechanisms Of Alcohol And Anesthetics written by Emanuel Rubin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Alcohol Cell Membranes And Signal Transduction In Brain
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Author : Christer Alling
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Alcohol Cell Membranes And Signal Transduction In Brain written by Christer Alling and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Alcohol abuse and alcoholism are international problems whose costs economical ly, psychologically and medically have been well documented. Alcohol is a unique drug in that the effects of excessive use can have a deleterious effect on most if not all organs of the body. The brain is one of the organs most affected by excessive alcohol consumption. Effects on the brain can be seen in cognitive function, brain structure and neurochemistry. Over the past few years, there have been significant advances made in understanding how alcohol affects brain neurochemistry. This book examines four major areas, i. e. , membrane lipids, receptors and ion channels, second messengers, and gene expression, where significant advancements have been made. The book is divided into four sections based on the four major areas. In each section, data are examined that cover a range of approaches from in vitro to in vivo studies. The section on membrane lipids includes recent developments in how ethanol affects membrane cholesterol domains, polyunsaturated fatty acids, the cause and consequences of phosphatidylethanol formation, and the modulation of membrane protein function by lipid-protein interaction. The second section comprises chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol neurotoxicity and the molecular heterogeneity that may underlie differences in alcohol sensitivity as well as chapters on GABA-gated chloride flux, and calcium channels.
Pharmacology Of Ionic Channel Function Activators And Inhibitors
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Author : M. Endo
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pharmacology Of Ionic Channel Function Activators And Inhibitors written by M. Endo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an electrical effect across the membrane or switches on a series of chemical or physicochemical reactions. This is a comprehensive book about these vitally important ion channels with detailed description of the molecular structure and function and especially of activators and inhibitors. All chapters are written by renowned specialists in their field.
National Library Of Medicine Current Catalog
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Author : National Library of Medicine (U.S.)
language : en
Publisher:
Release Date : 1991
National Library Of Medicine Current Catalog written by National Library of Medicine (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medicine categories.
Modern Anesthetics
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Author : Jürgen Schüttler
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-08
Modern Anesthetics written by Jürgen Schüttler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-08 with Medical categories.
Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.
Molecular And Cellular Mechanisms Of Anesthetics
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Author : S.H. Roth
language : en
Publisher: Springer
Release Date : 1986-03-31
Molecular And Cellular Mechanisms Of Anesthetics written by S.H. Roth and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-03-31 with Medical categories.
B. Raymond Fink Sheldon Roth and Keith Miller have asked me to record that the Third Conference on Molecular and Cellular Mechanisms of Anesthesia was held in Calgary last May "in my honor. " Such was my dear friends' gracious way of continuing a series that began at the University of Washington, where I hosted two, four, or five previous ones, 1,3-6 depending 2 on how far back one wishes to count. At that, Seattle took up where Paris left off in 1951. These occasions create their own unforgettable memories. This book captures the fine, invigorating ambience of the University of Calgary and the exciting explorations and com panionship of a gathering in a frontier territory of neuroscience. So, floreant symposia. They have progressively refined the quarry, from pathway to synapse to lipoprotein membrane to receptor and single channel, in heuristic convergences of neuronal physiology, biochemistry, and pharmacology. Nevertheless, the anesthesiologist in me senses a certain disquiet, a certain claustrophobia provoked by the narrow confines of micropipettes. How much more tubular must tunnel vision become before the desired broad view emerges? At present, the advances in molecular neurobiology seem continually to increase the apparent complexity of the total problem and the conceptual distance between the reductionists in the laboratories and the holists in the operating rooms. Happily, what is also growing is the excitement in trying to bridge the gap. Perhaps it would be timely to regard general anesthesia not as a state but as a syndrome.
Central Nervous System Monitoring In Anesthesia And Intensive Care
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Author : Jochen Schulte am Esch
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Central Nervous System Monitoring In Anesthesia And Intensive Care written by Jochen Schulte am Esch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Research in electrophysiologic monitoring in anesthesia and intensive care has focussed mostly on questions pertinent for patient care: First how to quantitate drug effects on brain electrical activity and the degree of anesthetic-induced suppression of the central nervous system. Second, how to monitor functional impairment following cerebral ischemia and hypoxia. And third, how to differ entiate between drug-induced effects on the central nervous system and deleteri ous events related to reductions in cerebral blood flow and/or oxygen delivery. Even though progress has been achieved over the last 10 years in this field and fascinating new techniques have been developed, it is still not clear which monitor parameter will provide adequate information on the depth of anes thesia and the analgesic level. Because the central nervous system has been one of the main research areas in our department over the last 10 years, we organized a workshop to summarize the latest developments in central nervous system monitoring. This book comprises the topics of this workshop and is intended to provide insight into the current status of central nervous system monitoring, elucidating possible indications and delineating its limitations.
Alcohol And Neurobiology
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Author : Ronald Ross Watson
language : en
Publisher: CRC Press
Release Date : 1992-06-24
Alcohol And Neurobiology written by Ronald Ross Watson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-06-24 with Science categories.
Public attention and research efforts are being driven by an ever- increasing understanding of the problems and magnitude of alcohol abuse, particularly its neurological consequences. Two out of three high school students report that they used alcohol during the previous month. This continuing source of potential abusers, plus 10 million alcohol-abusing adults, along with the several million abusers of other drugs, costs the people of the U.S. more than $200 billion in lost wages, health care, theft, and shortened life span. An intimate, detailed knowledge of the effects of alcohol on the biochemical reactions and neurological changes is critical in preventing or treating abuse. We must study the mechanisms of ethanol's effects on the neurological system at a cellular and systematic level to understand its actions. These include modifications of hormonal regulation and production with major functional consequences. The progress of research over the past decade is encouraging as we begin to summarize and evaluate in detail advances in understanding changes in the biochemistry and physiology caused by ethanol. This information will assist the researcher, clinician, and student in comprehending the complex changes caused by direct and indirect effects of single drugs at the cellular level.
Glutamate And Gaba Receptors And Transporters
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Author : Jan Egebjerg
language : en
Publisher: CRC Press
Release Date : 2001-10-04
Glutamate And Gaba Receptors And Transporters written by Jan Egebjerg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-10-04 with Medical categories.
The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover,