Molecular And Genetic Mechanisms In Neurodevelopmental Disorders From Bench To Bedside
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Molecular And Genetic Mechanisms In Neurodevelopmental Disorders From Bench To Bedside
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Author : Rebecca Ann Muhle
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-02
Molecular And Genetic Mechanisms In Neurodevelopmental Disorders From Bench To Bedside written by Rebecca Ann Muhle and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-02 with Science categories.
Innovative Approaches And Therapeutic Perspectives For Early Onset Neurodevelopmental Disorders From Bench To Bedside
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Author : Barbara Bardoni
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-11
Innovative Approaches And Therapeutic Perspectives For Early Onset Neurodevelopmental Disorders From Bench To Bedside written by Barbara Bardoni and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-11 with Science categories.
In partnership with the Jacques Monod Conference “Genetics, environment, signaling & synaptic plasticity in developmental brain disorders: from bench to bedside", the Frontiers in Neuroscience Journal announces an article collection that will highlight cutting-edge research presented at the 2022 meeting from Monday 11th Apr - Friday 15th Apr in Roscoff (Brittany). Neurodevelopmental Disorders (NDDs) are a highly heterogeneous group of disorders with a prevalence of 3% of the worldwide population. These disorders include Intellectual Disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder, specific learning disorder, motor and language disorder, schizophrenia, and epilepsy. Thus, NDDs are characterized by deficits in cognition, social interaction, behavior, and motor functioning as a result of abnormal brain development. Several of these phenotypes can co-exist in the same patient. Indeed, for instance, up to 50% of ASD patients display also ID. Similarly, the prevalence of epilepsy in ID patients is around 26%. This phenotypic overlap is also mirrored at the genetic and molecular levels. For instance, some pathways (e.g., Rho-GTPase, group I mGluRs, cAMP and WNT) have been found to be altered in different forms of NDDs, both of genetic and environmental origin.
Molecular Basis Of Neuropsychiatric Disorders From Bench To Bedside
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Author : Shafiqur Rahman
language : en
Publisher: Academic Press
Release Date : 2019-10-05
Molecular Basis Of Neuropsychiatric Disorders From Bench To Bedside written by Shafiqur Rahman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-05 with Science categories.
Progress in Molecular Biology and Translational Science, Volume 167, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to Models and Biological Targets in Drug Discovery for Attention Deficit Hyperactivity Disorder, Novel Targets for Parkinson-Depression Co-morbidity. Utility of Cannabidiol (CBD) in Neuropsychiatric Disorders: A Short Review of the Recent Pre-clinical and Clinical Findings, The Many Sides of Microglia in Alcohol Use Disorders, Stress, Anxiety, Molecular Targets and More, Calcineurin Signaling in Psychiatric Disorders, Emerging Evidence for the Role of Pituitary Adenylate Cyclase- Activating Peptide (PACAP) in Neuropsychiatric Disorders, and more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field
New Mechanisms And Therapeutics In Neurodevelopmental Disorders
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Author : Daniela Tropea
language : en
Publisher: Frontiers E-books
Release Date :
New Mechanisms And Therapeutics In Neurodevelopmental Disorders written by Daniela Tropea and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Neurodevelopmental disorders (NDDs) are severe, heritable conditions characterized by impaired brain development and disability in cognition, social interaction and behavior. Genetic predisposition appears to interact with environmental factors to produce the onset of the disease. In the last decade genomic analysis on NDDs advanced the knowledge of the genetic causes of these disorders: most of the genes identified were not predicted from known biology, and almost all of them engage in neurodevelopmental processes. However, the same studies revealed an unexpected outcome regarding the molecular etiology: many of the same susceptibility genes as well as molecular pathways are emerging across hitherto unrelated disorders- such as autism and schizophrenia- challenging how we conceptualize these conditions. These new discoveries call for the establishment of additional criteria for the classification of the genes and related phenotypes. Beyond the classical distinction according to diagnostic criteria, new parameters should be taken into account: the genetics, the neurobiology of the gene products and the molecular mechanisms that they control. Our broad understanding of NDDs, requires a combination of approaches, including human studies, animal models and theoretical computation. Indeed, progress in technology and the generation of accurate models are advancing the field, and the research is rapidly growing. This Research Topic presents recent advances in neurodevelopmental disorders from genes to systems, in single conditions and across different phenotypes, and report the newest treatments in use. Recognized experts in the field discuss recent findings in molecular studies, in vivo imaging, neuropsychology, neuropharmacology and computational neuroscience. This multidisciplinary approach enriches our understanding of the mechanisms involved in the onset and progression of NDDs with the perspective of revealing the biological signs of the disorders and identifying new therapeutics.
Treatment Of Neurodevelopmental Disorders
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Author : Randi Jenssen Hagerman
language : en
Publisher: Oxford University Press, USA
Release Date : 2014
Treatment Of Neurodevelopmental Disorders written by Randi Jenssen Hagerman and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Medical categories.
This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.
The Genetics Of Neurodevelopmental Disorders
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Author : Kevin J. Mitchell
language : en
Publisher: John Wiley & Sons
Release Date : 2015-07-21
The Genetics Of Neurodevelopmental Disorders written by Kevin J. Mitchell and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-21 with Medical categories.
Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.
Mechanisms And Genetics Of Neurodevelopmental Cognitive Disorders
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Author : Moyra Smith
language : en
Publisher: Academic Press
Release Date : 2021-04-25
Mechanisms And Genetics Of Neurodevelopmental Cognitive Disorders written by Moyra Smith and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-25 with Medical categories.
Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders. Discusses links between brain development, gene expression, and brain function Covers neural stem cells, proliferation, migration, differentiation, and neurogenesis Includes brain mapping, brain plasticity, epigenetics, neuroimmunology, and more Provides insight into causation and brain function in autism, attention deficit disorder, and learning disabilities Examines impact of society and environmental factors on mental health
Neurobiology Of Brain Disorders
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Author : Michael J. Zigmond
language : en
Publisher: Academic Press
Release Date : 2022-05-20
Neurobiology Of Brain Disorders written by Michael J. Zigmond and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-20 with Science categories.
Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function. Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more. Links basic, translational and clinical research on disorders of the nervous system Covers a vast array of neurological and psychiatric disorders, including Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson's, Huntington's, Alzheimer's, OCD, PTSD, schizophrenia, depression and pain Features new chapters on the effects of aging and isolation on brain health Expands coverage on disorders, including new chapters on fibromyalgia, chronic fatigue, and restless legs syndrome Features in-text summary points, special feature boxes and research questions
Genetic Models And Molecular Pathways Underlying Autism Spectrum Disorders
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-11-14
Genetic Models And Molecular Pathways Underlying Autism Spectrum Disorders written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-14 with Medical categories.
Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241 provides the most recent information on the animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, this volume also provides detailed chapters on a variety of specific topics, including An overview of genetic models of ASDs, Phenotypic modeling of ASD symptoms, Molecular mechanisms of NF1 model of ASD symptoms, Ube3a gene dosage disorders: molecular and circuit mechanisms of ASD, Circuit dysfunctions in ASD models, ERK signaling in genetic models of ASD, and more. Presents a timely, comprehensive assessment of the field Includes helpful summaries on current knowledge, gaps and future directions in autism research
Syndromic Neurosurgery An Issue Of Neurosurgery Clinics Of North America An Issue Of Neurosurgery Clinics Of North America E Book
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Author : James A. Stadler
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-11-24
Syndromic Neurosurgery An Issue Of Neurosurgery Clinics Of North America An Issue Of Neurosurgery Clinics Of North America E Book written by James A. Stadler and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-24 with Medical categories.
In this issue of Neurosurgery Clinics, Guest Editor James A. Stadler brings his considerable expertise to the topic of syndromic neurosurgery. Top experts in the field cover key topics such as Syndromic epilepsy, tumor syndromes, syndromic craniosynostosis, and more. Provides in-depth, clinical reviews on syndromic neurosurgery, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 14 relevant, practice-oriented topics including The history of syndromic neurosurgery; Multidisciplinary evaluation of neurosurgical patients with genetic syndromes; Neurosurgical evaluation and management of children with achondroplasia; Neurosurgical evaluation and management of patients with connective tissue disorders; and more.