Molecular Aspects Of Anticancer Drug Dna Interactions
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Molecular Aspects Of Anticancer Drug Dna Interactions
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Author : Stephen Neidle
language : en
Publisher: CRC Press
Release Date : 1994-05-03
Molecular Aspects Of Anticancer Drug Dna Interactions written by Stephen Neidle and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-05-03 with Medical categories.
This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.
Molecular Aspects Of Anticancer Drug Dna Interactions C1994
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Author : Stephen Neidle
language : en
Publisher:
Release Date : 1993
Molecular Aspects Of Anticancer Drug Dna Interactions C1994 written by Stephen Neidle and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Antimitotic agents categories.
Molecular Aspects Of Anticancer Drug Dna Interaction
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Author : Neidle
language : en
Publisher: CRC Press
Release Date : 1993-08-16
Molecular Aspects Of Anticancer Drug Dna Interaction written by Neidle and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-08-16 with Medical categories.
This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.
Molecular Aspects Of Anti Cancer Drug Action
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Author : Stephen Neidle
language : en
Publisher:
Release Date : 1983
Molecular Aspects Of Anti Cancer Drug Action written by Stephen Neidle and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Antimitotic agents categories.
Molecular Basis Of Specificity In Nucleic Acid Drug Interactions
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Author : A. Pullman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Basis Of Specificity In Nucleic Acid Drug Interactions written by A. Pullman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.
Drug Dna Interactions
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Author : Kazuo Nakamoto
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-08
Drug Dna Interactions written by Kazuo Nakamoto and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-08 with Science categories.
Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.
Metallopharmaceuticals I
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Author : Michael J. Clarke
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-05-21
Metallopharmaceuticals I written by Michael J. Clarke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-05-21 with Science categories.
Each volume provides the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, with a comprehensive summary and critical overview of a topic of great current interest written by leading international experts.
Drug Dna Interaction Protocols
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Author : Keith R. Fox
language : en
Publisher: Springer Science & Business Media
Release Date : 1997-10-07
Drug Dna Interaction Protocols written by Keith R. Fox and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-07 with Medical categories.
A collection of useful molecular techniques to illuminate and explore the interaction of drugs and ligands with DNA. These easily reproducible methods involve sequence recognition properties, as well as the physical approaches for measuring both the strength of interaction and the mode of drug binding to DNA. The interactions are also examined from a cellular perspective and for their usefulness in the design of new therapeutic agents. The powerful techniques detailed here will be particularly useful in elucidating the action of existing therapeutic agents, as well as in the design of new anti-cancer drugs with improved action and reduced toxicity.
Metallopharmaceuticals I
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Author : Michael J. Clarke
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Metallopharmaceuticals I written by Michael J. Clarke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
Each volume provides the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, with a comprehensive summary and critical overview of a topic of great current interest written by leading international experts.
Molecular And Clinical Advances In Anticancer Drug Resistance
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Author : Robert F. Ozols
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular And Clinical Advances In Anticancer Drug Resistance written by Robert F. Ozols and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The importance of drug resistance in cancer chemotherapy cannot be over stated. The 500,000 patients who die every year from cancer in the United States have, in most cases, been treated with chemotherapy. Many of these patients responded initially to chemotherapy, but death resulted from the development of drug-resistant tumors. In the first volume in the series. Drug Resistance in Chemotherapy the results of comprehensive laboratory studies aimed at understanding the mechanisms for resistance to individual agents and to the development of broad cross-resistance were described. In the past 2 years there has been substantial progress in understanding the molecular biology associated with these mechanisms of drug resistance. For the first time we are starting to understand which mechanisms are playing an im portant role in human tumors, and even more importantly, clinical trials have recently been initiated in an effort to reverse specific forms of drug resistance. The purpose of this volume is to describe the new advances, both at the molecular level and in the clinic regarding mechanisms of drug resistance and potential ways this resistance can be circumvented. This volume is focused upon mechanisms of resistance associated with two major classes of anticancer drugs: alkylating agents (including cisplatin) and the natural products (e. g. , adriamycin and vinblastine). The first section of the book describes new insights into the genetic mechanisms associated with drug resistance.