Molecular Aspects Of Oxidative Drug Metabolizing Enzymes
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Molecular Aspects Of Oxidative Drug Metabolizing Enzymes
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Author : Emel Arinc
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Molecular Aspects Of Oxidative Drug Metabolizing Enzymes written by Emel Arinc and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity.
Molecular And Applied Aspects Of Oxidative Drug Metabolizing Enzymes
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Author : Emel Arinç
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular And Applied Aspects Of Oxidative Drug Metabolizing Enzymes written by Emel Arinç and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Proceedings of a NATO ASI held in Antalya, Turkey, August 31 - September 11, 1997
Enzyme Kinetics In Drug Metabolism
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Author : Swati Nagar
language : en
Publisher:
Release Date : 2014
Enzyme Kinetics In Drug Metabolism written by Swati Nagar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Drugs categories.
Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning. Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.
Chemistry And Molecular Aspects Of Drug Design And Action
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Author : E. A. Rekka
language : en
Publisher: CRC Press
Release Date : 2008-04-28
Chemistry And Molecular Aspects Of Drug Design And Action written by E. A. Rekka and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-28 with Medical categories.
An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to deve
Activation And Detoxification Enzymes
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Author : Chang-Hwei Chen
language : en
Publisher: Springer Nature
Release Date :
Activation And Detoxification Enzymes written by Chang-Hwei Chen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Drug Metabolism And Transport
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Author : Lawrence H. Lash
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-06
Drug Metabolism And Transport written by Lawrence H. Lash and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-06 with Medical categories.
A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.
Drug Metabolism
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Author : Jack P. Uetrecht
language : en
Publisher: CRC Press
Release Date : 2007-06-21
Drug Metabolism written by Jack P. Uetrecht and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-21 with Medical categories.
In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structures and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This comprehensive textbook will aid in guiding students throu
Biochemistry Of Drug Metabolizing Enzymes
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Author : Muhammad Sajid Hamid Akash
language : en
Publisher: Elsevier
Release Date : 2022-06-06
Biochemistry Of Drug Metabolizing Enzymes written by Muhammad Sajid Hamid Akash and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-06 with Medical categories.
Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their contribution in the malfunctioning of drug metabolizing enzymes. This book is the perfect resource for pharmacology and biochemistry researchers to understand the principles of DMEs. Researchers in the corporate environment will also benefit from the comprehensive list of diseases associated with malfunction of DMEs. Includes extensive classification of DMEs, their mechanism of action and computational analysis Covers the biotransformation of drug by DMEs and the possible impact of environmental contaminants Discusses the activity of DMEs in different clinical conditions such as cardiovascular disease, metabolic disorders, inflammation and neurotoxicity Includes modern and novel bioanalytical techniques to predict the effect of DMEs
Adme Enabling Technologies In Drug Design And Development
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Author : Donglu Zhang
language : en
Publisher: John Wiley & Sons
Release Date : 2012-04-13
Adme Enabling Technologies In Drug Design And Development written by Donglu Zhang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-13 with Science categories.
A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
Enzyme Kinetics In Drug Metabolism
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Author : Swati Nagar
language : en
Publisher: Humana
Release Date : 2014-02-13
Enzyme Kinetics In Drug Metabolism written by Swati Nagar and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-13 with Medical categories.
Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning. Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.