Molecular Basis Of Mitochondrial Pathology


Molecular Basis Of Mitochondrial Pathology
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Molecular Basis Of Mitochondrial Pathology


Molecular Basis Of Mitochondrial Pathology
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Author : C. P. Lee
language : en
Publisher: Academic Press
Release Date : 2014-11-27

Molecular Basis Of Mitochondrial Pathology written by C. P. Lee and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-27 with Science categories.


The field of mitochondrial diseases is currently one of the rapidly growing fields of research in cell and molecular biology. This volume encompasses the latest development in this field of research. The chapters cover topics in a wide range of disciplines including biophysics, biochemistry, cell and molecular biology, molecular genetics, and clinical medicine. Summarizes growing evidence of the role of mitochondria in a large number of pathological conditions Brings together different approaches toward understanding mitochondria diseases Molecular and cellular biology Clinical physiology and medicine Details the crucial role this organelle plays in genetic regulation of various biological functions



Cellular And Molecular Basis Of Mitochondrial Inheritance


Cellular And Molecular Basis Of Mitochondrial Inheritance
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Author : Peter Sutovsky
language : en
Publisher: Springer
Release Date : 2019-05-09

Cellular And Molecular Basis Of Mitochondrial Inheritance written by Peter Sutovsky and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-09 with Science categories.


This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.



Mitochondrial Disorders Biochemical And Molecular Basis Of Disease


Mitochondrial Disorders Biochemical And Molecular Basis Of Disease
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Author : Grant M. Hatch
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-11

Mitochondrial Disorders Biochemical And Molecular Basis Of Disease written by Grant M. Hatch and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-11 with Science categories.




Molecular Basis For Mitochondrial Signaling


Molecular Basis For Mitochondrial Signaling
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Author : Tatiana K. Rostovtseva
language : en
Publisher: Springer
Release Date : 2017-05-12

Molecular Basis For Mitochondrial Signaling written by Tatiana K. Rostovtseva and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-12 with Science categories.


This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.



Molecular Basis Of Neurological Disorders And Their Treatment


Molecular Basis Of Neurological Disorders And Their Treatment
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Author : J.W. Gorrod
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Molecular Basis Of Neurological Disorders And Their Treatment written by J.W. Gorrod and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


cytochemical techniques (ICC) which provide a useful adjunct to investigations by immunoblotting. A particular advantage of a cytochemical approach to the investiga tion of mitochondrial disorders is that it allows the mosaic distribution of certain of these defects to be detected, whereas the tissue homogeniza tion involved in conventional enzyme assays or immunoblotting precludes this. A further advantage of MEA or ICC is that only small amounts of tissue are needed, which is important since many of the affected patients are infants or small children. The main aim of this communica tion is to outline ways in which these techniques can be used in the diagnosis and further investigation of mitochondrial disorders. Reference will be made not only to those situations in which MEA and ICC offer advantages over standard enzyme asays and immunoblotting but also to contexts in which the reverse applies. 4. 2 MATERIALS AND METHODS Muscle biopsies for cytochemical investigation were snap-frozen using isopentane cooled to - 150°C in liquid nitrogen. Samples were stored in heat-sealed polythene packets in the vapour phase of liquid nitrogen containers. 4. 2. 1 Microphotometric enzyme assays Frozen sections 8 Jlm thick were cut using a Reichert-J ung Frigocut cryostat microtome equipped with motor-driven cutting action to maintain maximal reproducibility of section thickness. Sections were picked up on microscope slides and air-dried for 15 min at room temperature.



Molecular Basis Of Mitochondrial Pathology


Molecular Basis Of Mitochondrial Pathology
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Author : C. P. Lee
language : en
Publisher: Academic Press
Release Date : 1994-11-10

Molecular Basis Of Mitochondrial Pathology written by C. P. Lee and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-11-10 with Science categories.


The field of mitochondrial diseases is currently one of the rapidly growing fields of research in cell and molecular biology. This volume encompasses the latest development in this field of research. The chapters cover topics in a wide range of disciplines including biophysics, biochemistry, cell and molecular biology, molecular genetics, and clinical medicine.



Molecular Pathology


Molecular Pathology
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Author : William B. Coleman
language : en
Publisher: Academic Press
Release Date : 2017-11-09

Molecular Pathology written by William B. Coleman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-09 with Medical categories.


As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase



Human Molecular Biology


Human Molecular Biology
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Author : R. J. Epstein
language : en
Publisher: Cambridge University Press
Release Date : 2003

Human Molecular Biology written by R. J. Epstein and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.


Human Molecular Biology is an introduction to the language of health and disease for the new generation of life scientists and medical students. By integrating cutting-edge molecular genetics and biochemistry with the latest clinical information, the book weaves a pattern which unifies biology with syndromes, genetic pathways with developmental phenotypes, and protein function with drug action. From the origins of life to the present day, a narrative is traced through the workings of genomes, cells and organ systems, culminating in linking of laboratory technologies to future research horizons.



Clinical Mitochondrial Medicine


Clinical Mitochondrial Medicine
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Author : Patrick F. Chinnery
language : en
Publisher: Cambridge University Press
Release Date : 2018-05-17

Clinical Mitochondrial Medicine written by Patrick F. Chinnery and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-17 with Medical categories.


This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice.



Molecular Basis Of Medical Cell Biology


Molecular Basis Of Medical Cell Biology
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Author : Gerald M. Fuller
language : en
Publisher: McGraw-Hill/Appleton & Lange
Release Date : 1998

Molecular Basis Of Medical Cell Biology written by Gerald M. Fuller and has been published by McGraw-Hill/Appleton & Lange this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.