Molecular Basis Of Nk Cell Recognition And Function

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Molecular Basis Of Nk Cell Recognition And Function

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Author : L. Moretta
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1996

Molecular Basis Of Nk Cell Recognition And Function written by L. Moretta and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.

Natural killer (NK) cells have been the subject of intense investigation. Only in recent years, however, could the molecular mechanisms by which they lyse tumor or virus-infected cells but spare normal cells be elucidated. NK cells express different specialized receptors (NK-R) specific for major histocompatibility complex (MHC) class I molecules. These MHC molecules exert an inhibitory effect on NK cells, i.e. lack of expression of one or more MHC class I alleles - a common event in tumor or virus-infected cells - leads to NK-mediated target cell lysis. Recently, NK-type receptors have also been identified in a subset of T lymphocytes. MHC/NK-R interaction causes inhibition of T cell activation and functions, an observation which suggests a role for these receptors in the negative control of T cell responses. This volume offers a complete and updated review of the signal transduction and functions of NK cells, as well as their roles in transplantation, anti-tumor response and infectious diseases. Written by experienced investigators, who have contributed significantly to progress in the field, this collection of reviews will be a valuable resource for basic and clinical immunologists, hematologists, oncologists and virologists.

Human B Cell Populations

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Author : Manlio Ferrarini
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1997-01-01

Human B Cell Populations written by Manlio Ferrarini and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-01 with Medical categories.

B cells used to be considered as a homogeneous population of cells destined to produce antibodies of increasing affinity and to maintain an immunological memory. In recent years, it has been determined that B cells can be subdivided into different subsets characterized by distinct morphologic, phenotypic, and functional features. Presenting results of research work on the definition of B cell subset populations, this book explains the basic mechanisms that control B cell activation, stimulation and regulation. Articles include studies on both normal and malignant B cells and describe the mechanisms underlying T-B cell interactions during the immune response. The most important advances in the field of immunodeficiency are also reported. This volume will be essential not only for basic and clinical immunologists, but also for hematologists, pathologists and rheumatologists with a special interest in the pathogenesis of lymphoproliferative or autoimmune disorders.

Specificity Function And Development Of Nk Cells

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Author : Klas Kärre
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Specificity Function And Development Of Nk Cells written by Klas Kärre and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recognition events lead to intracellular signals which can be either stimulatory or inhibitory. This book provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells, and into their biological role in controlling infections and tumors.

Hematology E Book

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Author : Leslie E. Silberstein
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-11-05

Hematology E Book written by Leslie E. Silberstein and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-05 with Medical categories.

Hematology, 6th Edition encompasses all of the latest scientific knowledge and clinical solutions in the field, equipping you with the expert answers you need to offer your patients the best possible outcomes. Ronald Hoffman, MD, Edward J. Benz, Jr., MD, Leslie E. Silberstein, MD, Helen Heslop, MD, Jeffrey Weitz, MD, John Anastasi, MD, and a host of world-class contributors present the expert, evidence-based guidance you need to make optimal use of the newest diagnostic and therapeutic options. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Make confident, effective clinical decisions by consulting the world's most trusted hematology reference. Access the complete contents online at www.expertconsult.com, with a downloadable image collection, regular updates, case studies, patient information sheets, and more. Apply all the latest knowledge on regulation of gene expression, transcription splicing, and RNA metabolism; pediatric transfusion therapy; principles of cell-based gene therapy; allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome in adults; hematology in aging; and much more, thanks to 27 brand-new chapters plus sweeping updates throughout. Find the information you need quickly and easily thanks to a completely reworked organization that better reflects today’s clinical practice. Visualize clinical problems more clearly with new and updated images that reflect the pivotal role of hematopathology in modern practice. Benefit from the experience and fresh perspective of new editor Dr. Jeffrey Weitz, Professor of Medicine at McMaster University School of Medicine and Executive Director of the Thrombosis and Atherosclerosis Research Institute in Ontario.

Biomedical Index To Phs Supported Research Pt A Subject Access A H

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Author :
language : en
Publisher:
Release Date : 1992

Biomedical Index To Phs Supported Research Pt A Subject Access A H written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medicine categories.

Cell Adhesion Molecules Advances In Research And Application 2011 Edition

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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09

Cell Adhesion Molecules Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Science categories.

Cell Adhesion Molecules: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cell Adhesion Molecules. The editors have built Cell Adhesion Molecules: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cell Adhesion Molecules in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cell Adhesion Molecules: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Biomedical Index To Phs Supported Research

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Author :
language : en
Publisher:
Release Date : 1991

Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medicine categories.

Innate Immune Cell Therapy Of Cancer

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Author : Asha B. Pillai
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-13

Innate Immune Cell Therapy Of Cancer written by Asha B. Pillai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-13 with Science categories.

Adoptive cellular immunotherapy of cancer, particularly chimeric antigen receptor-transduced T cell (CAR-T) therapies, have enjoyed an explosion of clinical trials and translational and basic research in the past decade. The concept and design of the CAR, though originally intended to optimize targeting of innate natural killer cells (NK cells) to tumor-specific antigens, was laterally applied in the past decade to conventional autologous and later third-party allogeneic T cells with first-in-kind successes in leukemia immunotherapy in both adults and children. This approach also spawned the development of an entire industry focused on cancer immunotherapy, laying the foundation for the current paradigm shifts away from toxic chemo/radiotherapy to immune targeting. Aside from cytokine-release toxicities, specific obstacles plaguing existing CAR-T cell therapies include suboptimal killing by fatigued or senescent autologous patient-derived T cells derived, acquisition of tumor resistance to T-cell based immune therapies, and graft-versus-host disease (GVHD) associated with allogeneic conventional T cell therapies.

Anticancer Research

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Author :
language : en
Publisher:
Release Date : 1997

Anticancer Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Cancer categories.

Biennial Scientific Report

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Author : Howard Hughes Medical Institute
language : en
Publisher:
Release Date : 1999

Biennial Scientific Report written by Howard Hughes Medical Institute and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Cytology categories.