Molecular Basis Of Sex Hormone Receptor Function
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Molecular Basis Of Sex Hormone Receptor Function
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Author : Hinrich Gronemeyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Molecular Basis Of Sex Hormone Receptor Function written by Hinrich Gronemeyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.
How sex hormone receptors and all the other members of the nuclear receptor superfamily do such a remarkable job has fascinated scientists for decades. A series of discoveries in the past few years has dramatically enlightened our understanding of the molecular mechanisms that govern nuclear receptor action. The elucidation of the 3D structures of several nuclear receptor ligand binding domains in the presence of agonists or antagonists has provided an allosteric concept of ligand action, and the discovery of a plethora of ligand-dependent protein interactions has linked this transconformation with the ability of nuclear receptors to act as transcriptional activators and repressors and the enzymatic modification of chromatin and factors of the basal transcriptional machinery.
Molecular Basis Of Sex Hormone Receptor Function
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Author : Hinrich Gronemeyer
language : en
Publisher:
Release Date : 2014-01-15
Molecular Basis Of Sex Hormone Receptor Function written by Hinrich Gronemeyer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Spectrum Of Sex
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Author : Minoru Tanaka
language : en
Publisher: Springer Nature
Release Date : 2022-11-07
Spectrum Of Sex written by Minoru Tanaka and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-07 with Science categories.
This book introduces cutting-edge studies on the spectrum of sex. The sex spectrum can be understood as an interwoven mechanism sustaining graded phenotypes between the two sexes. The book overviews three elements that develop the sex spectrum: genetics, the endocrine system, and the environment. Part I discusses the genetic regulation during sex determination, which often results in a mixture of two sexes or sex reversal. The evolutionary aspects of the genetic determinants are also discussed. Part II presents the involvement of endocrine regulation in the sex spectrum, which covers a broad range of phenotypic events, including sexual behavior and metabolism. Interestingly, sex hormones can also act as sex determinants. Finally, Part III shows that intrinsic factors, such as sex-determining genes and sex hormones, are not the only factors in sex development. The environment surrounding organisms, such as symbiosis and metabolism, act on the sex as critical factors, generating the sex spectrum. Determination and development of the two sexes have been a topic of great interest and a long-standing issue in biology. The book updates the conventional view that biological sex is fixed after birth and sets new perspectives for understanding sex as a spectrum manifested in multiple phenomena. Each chapter contributed by leading experts explains the sex spectrum in various organisms and their underlying mechanisms from the latest ongoing studies. The book provides a valuable resource for not only experts in developmental biology, physiology, and medical science, but also non-scientists and anyone interested in the topic.
Analysis Of The Molecular Basis Of Transcriptional Regulation By Thyroid Hormone And Estrogen Receptors
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Author : Jeffrey Morse Holloway
language : en
Publisher:
Release Date : 1992
Analysis Of The Molecular Basis Of Transcriptional Regulation By Thyroid Hormone And Estrogen Receptors written by Jeffrey Morse Holloway and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Sex Hormone Receptor Signals In Human Malignancies
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Author : Hiroshi Miyamoto
language : en
Publisher: MDPI
Release Date : 2019-10-01
Sex Hormone Receptor Signals In Human Malignancies written by Hiroshi Miyamoto and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-01 with Science categories.
Sex steroids, including androgens, estrogens, and progestogens, are known to have widespread physiological actions beyond the reproductive system via binding to the sex hormone receptors. Meanwhile, emerging evidence has indicated that sex hormone receptor signals are involved in the outgrowth of some malignancies, such as prostate and breast carcinomas, as well as others that have not traditionally been considered as endocrine-related neoplasms. This Special Issue “Sex Hormone Receptor Signals in Human Malignancies” covers various aspects of the potential role of sex hormone receptors and related signals in prostate cancer, breast cancer, and other neoplastic conditions by depicting promising findings derived from in vitro and in vivo experiments as well as the analyses of surgical specimens. The current observations described may thus provide a unique insight into novel or known functions of sex hormone receptors and related molecules.
Molecular Basis Of Sex Hormone Receptor Function
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Author : Hinrich Gronemeyer
language : en
Publisher: Springer
Release Date : 1998-09-01
Molecular Basis Of Sex Hormone Receptor Function written by Hinrich Gronemeyer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-09-01 with Science categories.
How sex hormone receptors and all the other members of the nuclear receptor superfamily do such a remarkable job has fascinated scientists for decades. A series of discoveries in the past few years has dramatically enlightened our understanding of the molecular mechanisms that govern nuclear receptor action. The elucidation of the 3D structures of several nuclear receptor ligand binding domains in the presence of agonists or antagonists has provided an allosteric concept of ligand action, and the discovery of a plethora of ligand-dependent protein interactions has linked this transconformation with the ability of nuclear receptors to act as transcriptional activators and repressors and the enzymatic modification of chromatin and factors of the basal transcriptional machinery.
Hormone Receptors In Breast Cancer
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Author : Suzanne A. W. Fuqua
language : en
Publisher: Springer
Release Date : 2008-11-01
Hormone Receptors In Breast Cancer written by Suzanne A. W. Fuqua and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-01 with Medical categories.
Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.
Hormone Receptors In Breast Cancer
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Author : Suzanne A. W. Fuqua
language : en
Publisher: Springer
Release Date : 2014-10-20
Hormone Receptors In Breast Cancer written by Suzanne A. W. Fuqua and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-20 with Medical categories.
Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.
Exploring The Biological Contributions To Human Health
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2001-07-02
Exploring The Biological Contributions To Human Health written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-02 with Medical categories.
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
Biological Mechanisms And The Advancing Approaches To Overcoming Cancer Drug Resistance
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Author : Andrew Freywald
language : en
Publisher: Academic Press
Release Date : 2020-12-02
Biological Mechanisms And The Advancing Approaches To Overcoming Cancer Drug Resistance written by Andrew Freywald and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-02 with Science categories.
Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies